The Suppositional Ramsey Test and Decision-Instability

I analyse the relationship between the Ramsey Test (RT) for the acceptance of indicative conditionals and the so-called problem of decision-instability. In particular, I argue that the situations which allegedly bring about this problem are troublesome just in case the relevant conditionals are evaluated by non-suppositional versions, e.g. causal/evidential, of the test. In contrast, a suppositional RT, by highlighting the metacognitive nature of the evaluation of indicative conditionals, allows an agent to run a simulation of such evaluation, without yet committing her to the acceptance of such conditionals. I conclude that a suppositional interpretation of RT is superior to its non-suppositional counterparts and by briefly showing that a suppositional RT is compatible with a deliberational decision theory.     

Objects and Levels: Reflections on the Relation Between Time-Consciousness and Self-Consciousness

The text surveys the development of the debate between Zahavi and Brough/Sokolowski regarding Husserl’s account of inner time-consciousness. The main arguments on both sides are reconsidered, and a compromise is proposed.     

If-Clauses and Probability Operators

Adams’ thesis is generally agreed to be linguistically compelling for simple conditionals with factual antecedent and consequent. We propose a derivation of Adams’ thesis from the Lewis-Kratzer analysis of if-clauses as domain restrictors, applied to probability operators. We argue that Lewis’s triviality result may be seen as a result of inexpressibility of the kind familiar in generalized quantifier theory. Some implications of the Lewis-Kratzer analysis are presented concerning the assignment of probabilities to compounds of conditionals.     

Visual search for schematic emotional faces risks perceptual confound

Several studies have used a visual search task to demonstrate that schematic negative-face targets are found faster and/or more efficiently than positive ones, with these findings taken as evidence that negative emotional expression is capable of guiding attentional allocation in visual search. A common hypothesis is that these effects should be disrupted by face inversion; however, this has not been consistently demonstrated, and raises the possibility of a perceptual confound. One candidate confound is the feature of "closure" (see Wolfe & Horowitz, 2004) caused by the down-turned mouth adjacent to edge of the face. This was investigated in the present series of experiments. In Experiment 1, the speed advantage for upright negative faces was replicated. In Experiment 2, the effect was not disrupted with inversion, and an efficiency advantage emerged, suggesting that perceptual features could be causing the advantage. In Experiment 3, speed and efficiency effects were seen when this perceptual characteristic remained but face features were scrambled. Taken together, these findings suggest that visual search using schematic faces containing a curved-line mouth feature cannot provide a valid test of guided search by negative facial emotion unless this confound is controlled.     

Public Trust in Genomic Risk Assessment for Type 2 Diabetes Mellitus

Patient trust in personal medical information is critical to increasing adherence to physician recommendations and medications. One of the anticipated benefits of learning of one’s genomic risk for common diseases is the increased adoption of screening, preventive care and lifestyle changes. However, the equivocal results thus far reported of the positive impact of knowledge of genomic risk on behavior change may be due to lack of patients’ trust in the results. As part of a clinical study to compare two methods of communication of genomic risk results for Type 2 diabetes mellitus (T2DM), we assessed patients’ trust and preferred methods of delivery of genomic risk information. A total of 300 participants recruited from the general public in Durham, NC were randomized to receive their genomic risk for T2DM in-person from a genetic counselor or online through the testing company’s web-site. Participants completed a baseline survey and three follow-up surveys after receiving results. Overall, participants reported high levels of trust in the test results. Participants who received their results in-person from the genetic counselor were significantly more likely to trust their results than those who reviewed their results on-line (p?=?0.005). There was not a statistically significant difference in levels of trust among participants with increased genetic risk, as compared to other those with decreased or same as population risk (p?=?0.1154). In the event they undergo genomic risk testing again, 55 % of participants overall indicated they would prefer to receive their results online compared to 28 % that would prefer to receive future results in-person. Of those participants preferring to receive results online, 77 % indicated they would prefer to have the option to speak to someone if they had questions with the online results (compared to accessing results online without the option of professional consultation). This is the first study to assess satisfaction with genomic risk testing by the method of delivery of the test result. The higher rate of trust in results delivered in-person suggests that online access reports may not result in serious consideration of results and lack of adoption of recommended preventive recommendations.     

Clinical Utility of Chromosomal Microarray Analysis of DNA from Buccal Cells: Detection of Mosaicism in Three Patients

Mosaic chromosomal abnormalities are relatively common. However, mosaicism may be missed due to multiple factors including failure to recognize clinical indications and order appropriate testing, technical limitations of diagnostic assays, or sampling tissue (s) in which mosaicism is either not present, or present at very low levels. Blood leukocytes have long been the “gold standard” sample for cytogenetic analysis; however, the culturing process for routine chromosome analysis can complicate detection of mosaicism since the normal cell line may have a growth advantage in culture, or may not be present in the cells that produce metaphases (the lymphocytes). Buccal cells are becoming increasingly utilized for clinical analyses and are proving to have many advantages. Buccal swabs allow for simple and noninvasive DNA collection. When coupled with a chromosomal microarray that contains single nucleotide polymorphic probes, analysis of buccal cells can maximize a clinician’s opportunity to detect cytogenetic mosaicism. We present three cases of improved diagnosis of mosaic aberrations using buccal specimens for chromosomal microarray analysis. In each case, the aberration was either undetectable in blood or present at such a low level it likely could have gone undetected. These cases highlight the limitations of certain laboratory methodologies for identifying mosaicism. We also present practice implications for genetic counselors, including clinic workflow changes and counseling approaches based on increasing use of buccal samples.     

Youth’s Help-Seeking Intentions for ADHD and Depression: Findings from a National Survey

This study investigates the role that youth-level factors play in predicting help-seeking intentions in a nationally representative sample. Eleven help-seeking intentions were examined separately by target conditions (ADHD and depression), gender, race/ethnicity, and self-reported diagnosed/non-diagnosed in respect to the target conditions, and interaction effects were tested. Using factor analysis, a traditional help-seeking scale was created, which captured four help-seeking items, and predictive power of youth-level factors in accounting for traditional help-seeking was tested. Study findings provide practitioners and researchers with fresh evidence on what youth-level factors are associated with which help-seeking intentions, and illustrate the challenges involved in better understanding the complexity of the help-seeking process among youth in the context of ADHD/Depression. With increased understanding of youth’s perceptions and the complexity of their help-seeking behavior, community-based efforts to develop effective strategies that support active help-seeking behavior and eliminate barriers to appropriate care can have a greater likelihood of success.