Biotinidase deficiency--a progressive metabolic disease in children with seizures and ataxia

Biotinidase deficiency is the primary biochemical defect in late-onset multiple carboxylase deficiency and an autosomal recessive disorder and characterized by seizures, ataxia, alopecia and skin rash. We describe a colorimetric semiquantitative method for screening for biotinidase activity from dried samples of whole blood spotted on filter papers. The administration of biotin to affected children can be a lifesaving procedure and can prevent irreversible neurologic damage.     

Does symptomatic schizophrenia exist?

The question if there are "symptomatic schizophrenias" has been discussed since the 20s. Schizophrenic psychoses caused be definable and well known brain diseases are presented. All schizophrenic symptoms and syndromes, the first rank symptoms (K. Schneider) too, occur in somatically founded psychoses. The group of paroxysmal transition syndromes in the sense of aura prolongata (continua) and the episodic schizophrenic psychoses in psychomotor epilepsy may be a model for the schizophrenia research. Vital threatening, so-called pernicious catatonic schizophrenias are found on the basis of infectious brain diseases, sometimes only diagnosed in autopsy. Beside acute and reversible symptomatic schizophrenic psychoses there are, even if rarely, recurrent and chronic courses of symptomatic schizophrenias. That certain conditions for the developing of symptomatic schizophrenias are rarely realised, could be an explanation for their rarity. Some findings indicate that the limbic system is significant for symptomatic (and idiopathic) schizophrenic psychoses and the pre- and postpsychotic basic stages determined by dynamic and cognitive basic symptoms, which are phenomenologically very similar to aura symptoms released by stereoelectroencephalographic depth recordings (Wieser). The characteristic features of marked fluctuation, discontinuity and insteadiness of the cognitive thought, perception, psychomotor and cenesthetic phenomena do not speak against an organic brain disorder provided that the traditional process hypothesis is abandoned in favor of a neurobiochemic disorder, fluctuating on its part depending on endogenous as well as psychic-reactive factors.     

Sense and counter-sense--on the deconstruction of histories

Today historiography (the writing of stories) presented as nothing but a search for truth merits the charge of naiveté. Since Freud we must understand any story told about life as a rationalization, that is, as a strategy of conducting one's life. The author argues the proposition that historiography can only fulfill its function of giving sense to life if it simultaneously admits its deconstruction, its counter-sense.     

Aspects of family-oriented diagnosis in compulsory legal family expert assessment

In forensic psychology, recommendations that courts request when granting one of the parents the right of child upbringing after a divorce pose a problem for the person who is required to give such expert judgment. The authors describe the difficult situation he faces when having to decide for and, at the same time, against one of the parents. A good knowledge of family psychology and pathopsychology is essential, and for drawing up the expertise and stating his reasons, the expert requires methodical resources. The authors describe four procedures of relational diagnosis and recommend the combined use of these in conjunction with methods that have been employed so far.     

Learning disabilities: an appraisal of Rorschach response patterns

Recent developments with the Rorschach invite research concerning cognitive and coping styles of learning disabled students. This study, based on an N of 25 (12 learning disabled and 13 controls), was designed to assess group differences in perceptual accuracy, self-concept, and reactivity. Analysis showed that learning disabled students represent a diverse population for which highly individualized understanding is required if appropriate schooling strategies are to be devised. Such students, compared with controls, were more inclined to have lower self-confidence, to be more reactive, to avoid emotionally-laden stimuli, to manifest a higher proportion of responses involving perceptual inaccuracies, and to be less spontaneous and less inclined to take risks. Some curricular implications of the findings are discussed.     

Information search following damage to the frontal lobes

Five adult patients with focal brain damage in different areas of the frontal lobes and five matched controls were administered a 20 Questions test. Other tests of planning, problem-solving, and decision-making were also administered to frontal lobe patients. The results indicate that damage to the frontal lobe impairs the ability to impose and utilize hierarchical organization in mental representation.     

Construction of a multidimensional scale of job satisfaction

A comprehensive, multidimensional scale measuring job satisfaction was constructed for use in a major project concerned with personnel recruitment and retention of health professionals. 11 dimensions relating to opinions of immediate supervisors, physical working conditions, satisfaction with coworkers and with pay, aspects related to promotion and work motivation, are identified. These dimensions are shown to distinguish among health professionals on sex and between locations and different occupations. The scale also has high internal validity, producing a multiple R of .78 with over-all job satisfaction.     

Measures of concurrent validity and alternate-form reliability of the Test of Nonverbal Intelligence

The subjects, 60 undergraduate students, were administered the Test of Nonverbal Intelligence (TONI) individually. The Shipley Institute of Living Scale was administered in small groups. A Pearson correlation of .56 was obtained for TONI Quotients, Forms A and B. TONI Quotients, Forms A and B, correlated with Shipley estimated WAIS--R IQ .50 and .46, respectively, and correlated to .71 and .64, with Shipley Total T scores, .52 and .44, respectively (corrected to .71 and .61), with Shipley Abstraction T scores, .51 and .42, respectively (corrected, .63 and .52), and with Shipley Vocabulary T scores .26 and .32, respectively (corrected to .63 and .52). TONI scores seem more closely related to Shipley Total and Abstraction scores than to Shipley Vocabulary.     

Psychotherapists' religious beliefs and their perception of the psychotherapy process

In a comparison of religious and nonreligious psychotherapists' perceptions of a portion of a psychotherapeutic session no significant differences were found on the Vanderbilt Psychotherapy Process Scale for four groups of therapists designated according to their scores on three religious questionnaires. While the results suggest attitudes toward religion are not reflected in therapists' practice of psychotherapy, limitations of the study indicate the need for more rigorous testing of this possibility.     

Analyzing sequential categorical data: Individual variation in markov chains

Markov chains are probabilistic models for sequences of categorical events, with applications throughout scientific psychology. This paper provides a method for anlayzing data consisting of event sequences and covariate observations. It is assumed that each sequence is a Markov process characterized by a distinct transition probability matrix. The objective is to use the covariate data to explain differences between individuals in the transition probability matrices characterizing their sequential data. The elements of the transition probability matrices are written as functions of a vector of latent variables, with variation in the latent variables explained through a multivariate regression on the covariates. The regression is estimated using the EM algorithm, and requires the numerical calculation of a multivariate integral. An example using simulated cognitive developmental data is presented, which shows that the estimation of individual variation in the parameters of a probability model may have substantial theoretical importance, even when individual differences are not the focus of the investigator's concerns.Research contributing to this article was supported by B.R.S. Subgrant 5-35345 from the University of Virginia. I thank the DADA Group, Bill Fabricius, Don Hartmann, William Griffin, Jack McArdle, Ivo Molenaar, Ronald Schoenberg, Simon Tavaré, and several anonymous reviewers for their discussion of these points.