Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue.

CONTEXT: Fatigue is among the most common and distressing symptoms experienced by cancer patients. OBJECTIVE: This systematic review and meta-analysis evaluates the efficacy of psychological and activity-based interventions against cancer-related fatigue in cancer patients. DATA SOURCES: MEDLINE, PsycINFO, and CINAHL. STUDY SELECTION: Randomized controlled trials of psychological and activity-based interventions involving adult cancer patients in which fatigue was an outcome were reviewed. EXTRACTION: Forty-one trials were reviewed and 30 were included in a meta-analysis. DATA SYNTHESIS: Fifty percent of psychological trials and 44% of activity-based trials rated fair or better in quality yielded significant findings favoring the intervention condition. Meta-analysis yielded an overall effect size of 0.09 (95% CI = .02- .16) favoring nonpharmacological conditions. Further analysis indicated that effect sizes were significant for psychological interventions (d-sub(w) = .10, 95% CI = .02-.18) but not activity-based interventions (d-sub(w) = .05, 95% CI = -.08 - .19). CONCLUSIONS: Findings provide limited support for use of nonpharmacological interventions to manage cancer-related fatigue. The lack of research with heightened fatigue as an eligibility criterion is a notable weakness of the existing evidence base.     

Test-retest reliability in fMRI of language: group and task effects

This paper explores how the test-retest reliability is modulated by different groups of participants and experimental tasks. A group of 12 healthy participants and a group of nine stroke patients performed the same language imaging experiment twice, test and retest, on different days. The experiment consists of four conditions, one audio condition and three audiovisual conditions in which the hands are either resting, gesturing, or performing self-adaptive movements. Imaging data were analyzed using multiple linear regression and the results were further used to generate receiver operating characteristic (ROC) curves for each condition for each individual subject. By using area under the curve as a comparison index, we found that stroke patients have less reliability across time than healthy participants, and that when the participants gesture during speech, their imaging data are more reliable than when they are performing hand movements that are not speech-associated. Furthermore, inter-subject variability is less in the gesture task than in any of the other three conditions for healthy participants, but not for stroke patients.     

Sympathy and callousness: The impact of deliberative thought on donations to identifiable and statistical victims

When donating to charitable causes, people do not value lives consistently. Money is often concentrated on a single victim even though more people would be helped, if resources were dispersed or spent protecting future victims. We examine the impact of deliberating about donation decisions on generosity. In a series of field experiments, we show that teaching or priming people to recognize the discrepancy in giving toward identifiable and statistical victims has perverse effects: individuals give less to identifiable victims but do not increase giving to statistical victims, resulting in an overall reduction in caring and giving. Thus, it appears that, when thinking deliberatively, people discount sympathy towards identifiable victims but fail to generate sympathy toward statistical victims.     

Error and bias in comparative judgment: on being both better and worse than we think we are

People believe that they are better than others on easy tasks and worse than others on difficult tasks. In previous attempts to explain these better-than-average and worse-than-average effects, researchers have invoked bias and motivation as causes. In this article, the authors develop a more parsimonious account, the differential information explanation, in which it is assumed only that people typically have better information about themselves than they do about others. When one's own performance is exceptional (either good or bad), it is often reasonable to assume others' will be less so. Consequently, people estimate the performance of others as less extreme (more regressive) than their own. The result is that people believe they are above average on easy tasks and below average on difficult tasks. These effects are exacerbated when people have accurate information about their performances, increasing the natural discrepancy between knowledge of the self and knowledge of others. The effects are attenuated when people obtain accurate information about the performances of others.     

The medium can influence the message: Print-based versus digital reading influences how people process different types of written information

While electronic reading devices are extremely popular, research is equivocal regarding their benefits for outcomes such as reader comprehension. Integrating literatures on reading medium comparisons and matching effects in persuasion, this research tested whether comprehension is maximized when the content of the material (e.g., whether it is traditional vs. modern) matches the medium (e.g., reading from a traditional book vs. digital e-reader). In Study 1, participants read a traditional- or modern-themed short story from either a book or an e-reader. Story comprehension was greater when participants read from the printed medium compared to the e-reader, an effect that was marginally moderated by story content, consistent with a matching effect. In Study 2, participants read a persuasive message that emphasized either a traditional versus modern solution to improving health in either a magazine format or on an iPad. Message comprehension was marginally greater among participants who read their message in a printed format. Participants’ interest in weight loss showed evidence of a matching effect – participants were more interested in losing weight when a modern solution to obesity article was presented on an iPad compared to a printed format. The results are applied to the study of reading and attitude change.     

Numerosity discrimination in deep neural networks: Initial competence,developmental refinement and experience statistics

Both humans and non‐human animals exhibit sensitivity to the approximate number of items in a visual array, as indexed by their performance in numerosity discrimination tasks, and even neonates can detect changes in numerosity. These findings are often interpreted as evidence for an innate ‘number sense’. However, recent simulation work has challenged this view by showing that human‐like sensitivity to numerosity can emerge in deep neural networks that build an internal model of the sensory data. This emergentist perspective posits a central role for experience in shaping our number sense and might explain why numerical acuity progressively increases over the course of development. Here we substantiate this hypothesis by introducing a progressive unsupervised deep learning algorithm, which allows us to model the development of numerical acuity through experience. We also investigate how the statistical distribution of numerical and non‐numerical features in natural environments affects the emergence of numerosity representations in the computational model. Our simulations show that deep networks can exhibit numerosity sensitivity prior to any training, as well as a progressive developmental refinement that is modulated by the statistical structure of the learning environment. To validate our simulations, we offer a refinement to the quantitative characterization of the developmental patterns observed in human children. Overall, our findings suggest that it may not be necessary to assume that animals are endowed with a dedicated system for processing numerosity, since domain‐general learning mechanisms can capture key characteristics others have attributed to an evolutionarily specialized number system.     

Reminders of secular authority reduce believers' distrust of atheists

Atheists have long been distrusted, in part because they do not believe that a watchful, judging god monitors their behavior. However, in many parts of the world, secular institutions such as police, judges, and courts are also potent sources of social monitoring that encourage prosocial behavior. Reminders of such secular authority could therefore reduce believers' distrust of atheists. In our experiments, participants who watched a video about police effectiveness (Experiment 1) or were subtly primed with secular-authority concepts (Experiments 2-3) expressed less distrust of atheists than did participants who watched a control video or were not primed, respectively. We tested three distinct alternative explanations for these findings. Compared with control participants, participants primed with secular-authority concepts did not exhibit reduced general prejudice against out-groups (Experiment 1), prejudice reactions associated with functional threats that particular out-groups are perceived to pose (specifically, viewing gays with disgust; Experiment 2), or general distrust of out-groups (Experiment 3). These findings contribute to theory regarding both the psychological bases of prejudices and the psychological functions served by gods and governments.     

Family History and APOE-4 Genetic Risk in Alzheimer’s Disease

Identifying risk factors for Alzheimer's disease, such as carrying the APOE-4 allele, and understanding their contributions to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic strategies. A first-degree family history of Alzheimer's disease represents a composite risk factor, which reflects the influence of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer's disease research and ultimately clinical practice.     

Psychological Epistemology: Epistemological Psychology

In his 2010 book Being Human: Human Being, Rue Cromwell developed some key ideas for reforming psychology. These include resolving the conundrum of subject, object, and consciousness in science; sorting through the tangles of meaning in superficially similar but fundamentally different epistemologies; and reversing conflation of cultural, social, and economic values with those of science. This discussion applies those ideas to some particulars of clinical psychology, psychopathology and the treatment and rehabilitation of severe and disabling mental illness.