Psychoimmunology and aids: Psychological distress and herpes simplex virus in human immunodeficiency virus infected individuals

Abstract

No studies investigating the relationship of herpesviruses and psychological distress in Human Immunodeficiency Virus (HIV) infection are available in the literature. Antibody titers for Cytomegalovirus (CMV), Epstein-Barr (EBV) and Herpes Simplex virus (HSV) were assessed from sera drawn at the lime of psychological testing for one hundred HIV seropositive subjects. Increased psychological distress was correlated with increased titers of antibody to HSV, but not to CMV or EBV. Psychological distress may play a role in the devastating HSV infections experienced by immune deficient individuals. A stress mediated reactivation/potentiation hypothesis is discussed, where distress reactivates latent HSV which in turn potentiates HIV replication. These results may have implications for treatment of individuals co-infected with HIV and HSV.     

A Short Letter on Religious Toleration

This paper takes the form of aletter to fledgling democracies such asAlgeria, Turkey, and Iran. It explores thenature of democracy and argues that theequality of citizens requires that differentreligions be treated equally. It presents some``lessons' from United States constitutionalhistory which might be useful to fledglingdemocracies as they seek to achieve aseparation of church and state. Developing atheme first presented in ``A Third Principle ofJustice,' The Journal of Ethics 1 (1997),pp. 355–374, it argues that religious tolerationsometimes may require a heightened sensitivityto the needs of some religious associations. Itconcludes, however, that religious tolerationdoes not require a toleration of intolerantreligious extremists who pose a threat todemocracy.     

Lesion analysis of the brain areas involved in language comprehension

The cortical regions of the brain traditionally associated with the comprehension of language are Wernicke's area and Broca's area. However, recent evidence suggests that other brain regions might also be involved in this complex process. This paper describes the opportunity to evaluate a large number of brain-injured patients to determine which lesioned brain areas might affect language comprehension. Sixty-four chronic left hemisphere stroke patients were evaluated on 11 subtests of the Curtiss-Yamada Comprehensive Language Evaluation - Receptive (CYCLE-R; Curtiss, S., & Yamada, J. (1988). Curtiss-Yamada Comprehensive Language Evaluation. Unpublished test, UCLA). Eight right hemisphere stroke patients and 15 neurologically normal older controls also participated. Patients were required to select a single line drawing from an array of three or four choices that best depicted the content of an auditorily-presented sentence. Patients' lesions obtained from structural neuroimaging were reconstructed onto templates and entered into a voxel-based lesion-symptom mapping (VLSM; Bates, E., Wilson, S., Saygin, A. P., Dick, F., Sereno, M., Knight, R. T., & Dronkers, N. F. (2003). Voxel-based lesion-symptom mapping. Nature Neuroscience, 6(5), 448-450.) analysis along with the behavioral data. VLSM is a brain-behavior mapping technique that evaluates the relationships between areas of injury and behavioral performance in all patients on a voxel-by-voxel basis, similar to the analysis of functional neuroimaging data. Results indicated that lesions to five left hemisphere brain regions affected performance on the CYCLE-R, including the posterior middle temporal gyrus and underlying white matter, the anterior superior temporal gyrus, the superior temporal sulcus and angular gyrus, mid-frontal cortex in Brodmann's area 46, and Brodmann's area 47 of the inferior frontal gyrus. Lesions to Broca's and Wernicke's areas were not found to significantly alter language comprehension on this particular measure. Further analysis suggested that the middle temporal gyrus may be more important for comprehension at the word level, while the other regions may play a greater role at the level of the sentence. These results are consistent with those seen in recent functional neuroimaging studies and offer complementary data in the effort to understand the brain areas underlying language comprehension.     

Between Subjugation and Survival: Women, Borderline Personality Disorder and High Security Mental Hospitals

Women in high security mental health care are frequently diagnosed with borderline personality disorder. Such women commonly report histories of child abuse, in particular child sexual abuse, and the vast majority also self-harm. In this paper, we draw on social constructionist theory to develop a framework for understanding these women, the effects of abuse and the reasons they self-harm. We demonstrate how a social model of intervention provides a comprehensive framework for identifying and exploring relevant factors within therapy. We argue that diagnostic categorisation has limited utility in directing therapeutic work with this particular group of women, because it directs attention away from the social world to internal pathology. We demonstrate that it is with reference to women's past and current relationships that borderline behaviour can be understood to be meaningful and partially adaptive. We conclude that treatment is more usefully organised around and directed towards those factors, such as abuse and self-harm, that are implicated in women's ongoing relationship difficulties.     

Conditional standard errors of measurement for composite scores on the Wechsler Preschool and Primary Scale of Intelligence-Third Edition

A specific recommendation of the 1999 Standards for Educational and Psychological Testing by the American Educational Research Association, the American Psychological Association, and the National Council on Measurement in Education is that test publishers report estimates of the conditional standard error of measurement (SEM). Procedures for calculating the conditional (score-level) SEM based on raw scores are well documented; however, few procedures have been developed for estimating the conditional SEM of subtest or composite scale scores resulting from a nonlinear transformation. Item response theory provided the psychometric foundation to derive the conditional standard errors of measurement and confidence intervals for composite scores on the Wechsler Preschool and Primary Scale of Intelligence-Third Edition.     

Secularization and the Wider Gap in Values and Personal Religiosity Between the Religious and Nonreligious

Increasing proportions of religious nonaffiliation characterize most Western societies, although the periods over which these increases have occurred and the speed in which they happen do vary. Consequently, some nations now have larger unaffiliated groups and others much smaller ones. What is less well known is if, in areas where unaffiliated groups are larger, the religious “nones” have become more distinct from the actively religious in their attitudes and behavior. In contexts of advanced secularization, to what extent is the gap greater between the actively religious and the nonreligious when it comes to their views on family life and reproduction, for example? In regards to their levels of religiosity and spirituality in their private lives? Are the unaffiliated more liberal in their attitudes and less religious in their private life? This article sheds light on these questions by analyzing data from over 200 North American, European, and Oceanic country subregions included in the 2008 International Social Survey Programme. With hierarchical linear models, I find that, in areas where the unaffiliated form a larger proportion of the population, the differences between the actively religious and the unaffiliated in family values and personal religiosity tend to be greater.     

Bogus physiological feedback and response thresholds of Repressers and Sensitizers

Repressers and Sensitizers viewed tachistoscopically presented TAT transparencies under conditions of high and low bogus physiological feedback. As predicted, during high bogus physiological feedback, Repressers showed a significant increase and Sensitizers showed a significant decrease in response thresholds. These results serve to extend the validity of bogus physiological feedback procedures in the analog investigation of emotion and offer theoretical implications relevant to the areas of personality, emotion, psychophysiology, and psychopathology.     

Visual recognition under conditions of high and low discrimination redundancy

The purpose of this investigation was to measure the minimum interval for recognition under conditions of high and low discrimination redundancy. The minimum interval for recognition is the briefest interval between two stimuli at which the first stimulus can be processed. Two sets of four digits were used. Digits were selected so that one set exhibited high discrimination redundancy and the other low discrimination redundancy. Ten Ss viewed digits with high discrimination redundancy, and 10 Ss viewed digits with low discrimination redundancy. The minimum interval for recognition for Ss tested with high discrimination redundancy was nearly twice as large as the minimum interval for recognition of the digits with low discrimination redundancy.