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Cocaine is a type of drug that functions to increase the availability of the neurotransmitter dopamine in the brain. However, cocaine dependence or abuse is highly related to an increased risk of psychiatric disorders and deficits in cognitive performance, attention, and decision-making abilities. Given the chronic and persistent features of drug addiction, the progression of abstaining from cocaine often evolves across several states, such as addiction to, moderate dependence on, and swearing off cocaine. Hidden Markov models (HMMs) are well suited to the characterization of longitudinal data in terms of a set of unobservable states, and have increasingly been used to uncover the dynamic heterogeneity in progressive diseases or activities. However, the existence of outliers or influential points may misidentify the hidden states and distort the associated inference. In this study, we develop a Bayesian local influence procedure for HMMs with latent variables in the presence of missing data. The proposed model enables us to investigate the dynamic heterogeneity of multivariate longitudinal data, reveal how the interrelationships among latent variables change from one state to another, and simultaneously conduct statistical diagnosis for the given data, model assumptions, and prior inputs. We apply the proposed procedure to analyze a dataset collected by the UCLA center for advancing longitudinal drug abuse research. Several outliers or influential points that seriously influence estimation results are identified and removed. The proposed procedure also discovers the effects of treatment and individuals’ psychological problems on cocaine use behavior and delineates their dynamic changes across the cocaine-addiction states. 相似文献
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在现代社会,道教的饮食养生文化受到了大众的普遍关注.然而,这不单单是因为道教中积累了大量的可供今人借鉴、利用的饮食方法和技术.实际上,道教的核心饮食养生思想及原则,更彰显出了其永久性的价值和魅力.从某种意义而言,更加清晰、深入地了解道教饮食养生思想内核,并把握其内在的科学精神实质,是进一步把道教饮食养生文化发扬光大的重要前提之一. 相似文献
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In the present article, we propose a three-stage memory marker model of memory for experience. The human mind generates and encodes “memory markers” of specific episodes, stores them in memory, and after a temporal delay retrieves these markers to reconstruct the experience and make relevant judgments. Rich experiences characterized by vivid stimuli seem to pass by quickly, yet feel longer when recalled after a period of time because the number of retrieved memory markers is large. We also examine situations in which key predictions of the memory marker model can be moderated. A field study and five laboratory experiments were conducted to test various aspects of the memory marker model and provide process support. 相似文献
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以往研究发现,动画教学代理对多媒体学习效果的影响不一致,可能受到学习者特征和偏好的调节。本研究以“空调的组成部分及工作原理”为实验材料,采用两个实验控制教学代理有无、经验高低和代理偏好,探讨动画教学代理对多媒体学习的影响。实验1发现与无代理组相比,代理组对教学视频的注视点个数更多,平均眼跳潜伏期更短,学习兴趣也更高;低经验者在代理条件下的迁移成绩更好。实验2发现学习者在偏好代理和非偏好代理条件下的迁移成绩好于无代理组;偏好代理组感知到更低的认知负荷,对总体视频的注视点个数和注视频率更多,平均眼跳潜伏期更短,对学习内容的注视点个数更多。结论认为:在多媒体中加入教学代理不会减少学习者对学习内容的注意,能提高多媒体学习效果,支持社会代理理论假设;教学代理能提高低经验者的学习效果,但对高知识经验者无明显作用;加入学习者偏好的代理形象会促进学习,但加入学习者非偏好的代理形象并没有阻碍学习。 相似文献
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Yilun Cai 《Heythrop Journal》2024,65(2):138-151
The Jesuit missionary Matteo Ricci's teaching on the goodness of human nature in The True Meaning of the Lord of Heaven represents the fruit of the first encounter between Catholicism and Confucianism. This article will consider the Thomistic and neo-Confucian sources in Ricci's enunciation of the Catholic doctrine on the goodness of human nature in this Chinese catechism. It will illustrate that Ricci developed his teaching, which is fundamentally Thomistic, with the help of terminology borrowed from the Chinese philosophical tradition. His distinction between the good of nature and the good of virtue leads to prioritising the cultivation of human nature. Ricci's teaching reflects the early modern Jesuits’ appreciation of human freedom. It also displays a Catholic reaction to the sixteenth-century neo-Confucian intellectual trend that ignored the importance of moral cultivation. 相似文献
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