Genetic Cancer Risk Assessment and Counseling: Recommendations of the National Society of Genetic Counselors

These cancer genetic counseling recommendations describe the medical, psychosocial, and ethical ramifications of identifying at-risk individuals through cancer risk assessment with or without genetic testing. They were developed by members of the Practice Issues Subcommittee of the National Society of Genetic Counselors Cancer Genetic Counseling Special Interest Group. The information contained in this document is derived from extensive review of the current literature on cancer genetic risk assessment and counseling as well as the personal expertise of genetic counselors specializing in cancer genetics. The recommendations are intended to provide information about the process of genetic counseling and risk assessment for hereditary cancer disorders rather than specific information about individual syndromes. Key components include the intake (medical and family histories), psychosocial assessment (assessment of risk perception), cancer risk assessment (determination and communication of risk), molecular testing for hereditary cancer syndromes (regulations, informed consent, and counseling process), and follow-up considerations. These recommendations should not be construed as dictating an exclusive course of management, nor does use of such recommendations guarantee a particular outcome. These recommendations do not displace a health care provider's professional judgment based on the clinical circumstances of a client.     

The outcomes and correlates of job search objectives: searching to leave or searching for leverage?

The authors investigate a previously overlooked yet important objective for employee job search--seeking leverage against the current employer. They explore the outcomes and correlates of leverage-seeking search and how it may differ from the more traditional objective for engaging in job search--to change jobs. Results show that leverage-seeking and separation-seeking search objectives associate with different outcomes. The authors also find that characteristics of the work situation and individual differences associate with leverage-seeking search and relate differently with the 2 job search objectives. Implications for practice and the advancement of job search research are discussed.     

Do college students drink more than their non-college-attending peers? Evidence from a population-based longitudinal female twin study

The association of college attendance with alcohol use and alcohol use disorders was examined in a population-based young adult female twin sample identified from a systematic search of birth records. College-attending women consumed a larger overall volume of alcohol than did their non-college-attending peers, but they were not more likely to be diagnosed with an alcohol use disorder. Significant associations between college attendance and alcohol involvement were probed using 3 different complementary research designs: multivariate cross-sectional analyses, longitudinal analyses of the precollege and college years, and cotwin-control analyses of twin pairs discordant for attending college. Although demographic and lifestyle characteristics accounted for most or all of the association between college attendance and alcohol involvement, there was 1 aspect of drinking behavior, occasionally consuming large quantities of alcohol, that remained significantly associated with college attendance even after controlling for these characteristics or for genetic and family background factors. These results are consistent with the conclusion that some aspect of the college experience may be an important environmental risk factor for this pattern of drinking among young adults.     

Repetition priming in picture naming and translation depends on shared processes and their difficulty: evidence from spanish-english bilinguals

Two experiments with highly fluent Spanish-English bilinguals examined repetition priming of picture identification and word retrieval in picture naming. In Experiment 1, between-language priming of picture naming was symmetric, but within-language priming was stronger in the nondominant language. In Experiment 2, priming between picture naming and translation was symmetric within both the dominant language and the nondominant language, but priming was stronger in the nondominant language. A mathematical model required only 3 process parameters to explain the pattern of priming across 8 conditions. These results indicate that shared processes are the basis of priming, that difficulty influences priming only at the process level, and that translation in both directions is concept mediated in fluent bilinguals.     

A Kripke Semantics for the Logic of Gelfand Quantales

Gelfand quantales are complete unital quantales with an involution, *, satisfying the property that for any element a, if a b a for all b, then a a* a = a. A Hilbert-style axiom system is given for a propositional logic, called Gelfand Logic, which is sound and complete with respect to Gelfand quantales. A Kripke semantics is presented for which the soundness and completeness of Gelfand logic is shown. The completeness theorem relies on a Stone style representation theorem for complete lattices. A Rasiowa/Sikorski style semantic tableau system is also presented with the property that if all branches of a tableau are closed, then the formula in question is a theorem of Gelfand Logic. An open branch in a completed tableaux guarantees the existence of an Kripke model in which the formula is not valid; hence it is not a theorem of Gelfand Logic.     

Family and Contextual Predictors of Depressive Symptoms in Inner-City African American Youth

Family and contextual predictors of depression in inner-city, African American youth have rarely been examined. In this study we explore the contribution of current and historical life events, family conflict, perceived social support from mother, maternal depression, and maternal explanatory style to the depressive symptoms of inner-city African American school-age (M = 10.7 years) children. Home interviews were conducted with 89 mother and child dyads living in moderate- to high-violent areas of a southeastern city. Regression analyses revealed that the children in this sample with higher levels of depressive symptoms had higher levels of child-reported everyday stress, were more likely to have been abused at some point in their past, came from homes with mothers who were less well educated, and had mothers who reported higher levels of depression, a past history of domestic abuse, as well as a less pessimistic explanatory style. Implications for interventions with inner-city African American families are discussed.     

Gender Differences in the Relation Between Neighborhood Quality and Cardiovascular Reactivity in African American Adolescents1

Although research on the influence of neighborhoods on the development of youth is growing, few researchers have examined the impact of neighborhood quality on physiological outcomes or across gender. The present experiment examined gender differences in the association of neighborhood quality and cardiovascular reactivity (increased blood pressure, BP, in response to stress) among 77 healthy African American adolescents (46% male; M age = 14 years). Participants took part in a cold-face stimulus task to determine reactivity scores. After controlling for baseline BP, family income, and parental education, poorer neighborhood quality was associated with increases in both systolic and diastolic BP to the cold-face task for females, and decreases in BP for males. Adolescents’ reports of life stress and support from family members did not explain the differential effect of neighborhood quality across gender. Implications for future research are discussed.