Genetic Cancer Risk Assessment and Counseling: Recommendations of the National Society of Genetic Counselors

These cancer genetic counseling recommendations describe the medical, psychosocial, and ethical ramifications of identifying at-risk individuals through cancer risk assessment with or without genetic testing. They were developed by members of the Practice Issues Subcommittee of the National Society of Genetic Counselors Cancer Genetic Counseling Special Interest Group. The information contained in this document is derived from extensive review of the current literature on cancer genetic risk assessment and counseling as well as the personal expertise of genetic counselors specializing in cancer genetics. The recommendations are intended to provide information about the process of genetic counseling and risk assessment for hereditary cancer disorders rather than specific information about individual syndromes. Key components include the intake (medical and family histories), psychosocial assessment (assessment of risk perception), cancer risk assessment (determination and communication of risk), molecular testing for hereditary cancer syndromes (regulations, informed consent, and counseling process), and follow-up considerations. These recommendations should not be construed as dictating an exclusive course of management, nor does use of such recommendations guarantee a particular outcome. These recommendations do not displace a health care provider's professional judgment based on the clinical circumstances of a client.     

The outcomes and correlates of job search objectives: searching to leave or searching for leverage?

The authors investigate a previously overlooked yet important objective for employee job search--seeking leverage against the current employer. They explore the outcomes and correlates of leverage-seeking search and how it may differ from the more traditional objective for engaging in job search--to change jobs. Results show that leverage-seeking and separation-seeking search objectives associate with different outcomes. The authors also find that characteristics of the work situation and individual differences associate with leverage-seeking search and relate differently with the 2 job search objectives. Implications for practice and the advancement of job search research are discussed.     

A Kripke Semantics for the Logic of Gelfand Quantales

Gelfand quantales are complete unital quantales with an involution, *, satisfying the property that for any element a, if a b a for all b, then a a* a = a. A Hilbert-style axiom system is given for a propositional logic, called Gelfand Logic, which is sound and complete with respect to Gelfand quantales. A Kripke semantics is presented for which the soundness and completeness of Gelfand logic is shown. The completeness theorem relies on a Stone style representation theorem for complete lattices. A Rasiowa/Sikorski style semantic tableau system is also presented with the property that if all branches of a tableau are closed, then the formula in question is a theorem of Gelfand Logic. An open branch in a completed tableaux guarantees the existence of an Kripke model in which the formula is not valid; hence it is not a theorem of Gelfand Logic.     

Family and Contextual Predictors of Depressive Symptoms in Inner-City African American Youth

Family and contextual predictors of depression in inner-city, African American youth have rarely been examined. In this study we explore the contribution of current and historical life events, family conflict, perceived social support from mother, maternal depression, and maternal explanatory style to the depressive symptoms of inner-city African American school-age (M = 10.7 years) children. Home interviews were conducted with 89 mother and child dyads living in moderate- to high-violent areas of a southeastern city. Regression analyses revealed that the children in this sample with higher levels of depressive symptoms had higher levels of child-reported everyday stress, were more likely to have been abused at some point in their past, came from homes with mothers who were less well educated, and had mothers who reported higher levels of depression, a past history of domestic abuse, as well as a less pessimistic explanatory style. Implications for interventions with inner-city African American families are discussed.     

Elemental and Configural Processes in Patterning Discrimination Learning

Three experiments used appetitive conditioning with rats to examine the involvement of elemental and configural processes in positive and negative patterning discriminations. The first experiment demonstrated that negative and, to some extent, positive patterning discriminations were learned more rapidly when these discriminations consisted of stimulus elements that had previously been the reinforced as opposed to the non-reinforced elements of a simple discrimination. Experiment 2 revealed an excitatory summation effect during the early phase of negative patterning learning that depended upon discrimination pretraining. The final experiment demonstrated faster discrimination learning between the compound and the less salient, rather than the more salient, element of an instrumental patterning task. The present set of results were interpreted as reflecting the possibility, consistent with connectionist theory, that internal representations of the conditioned stimuli change over the course of a patterning discrimination.     

Familiar idiom comprehension

Sentences containing idioms used either literally or figuratively were presented repeatedly for 100 msec per presentation. Half of the sentences were preceded by a paragraph. The number of presentations required to read the sentences and cued recall of the sentences were recorded. The serial brief presentations method provided predictable and meaningful results. Sentences containing idioms used literally required more presentations than those containing idioms used figuratively. Cued recall was better for idioms used literally than for those used figuratively. These results are interpreted as support for the Idiomatic Processing Model of idiom comprehension, which suggests that the figurative meaning is processed first; only if that one is inappropriate is the literal meaning processed.     

Is masked neighbor priming inhibitory? Evidence using the incremental priming technique

To investigate neighbor effects in visual word recognition, the masked priming technique holds considerable advantages over unprimed methods, because a target word is used as its own control. However, inhibitory neighbor effects obtained with masked priming are still open for different interpretations, because the primes differ across conditions. Given this theoretical problem, it is useful to investigate neighbor priming effects using a prime as its own control. This option is available in the incremental priming technique (Jacobs, Grainger, & Ferrand, 1995), in which a within-condition baseline is created by comparing the response times (RTs) to a target when it is primed at different prime durations. In this study, we examined masked neighbor priming using this technique. Both the traditional and the within-condition baseline indicated that masked neighbor word priming is inhibitory in nature. The results are discussed in terms of current theories of visual word recognition.     

A new look at habits and the habit-goal interface

The present model outlines the mechanisms underlying habitual control of responding and the ways in which habits interface with goals. Habits emerge from the gradual learning of associations between responses and the features of performance contexts that have historically covaried with them (e.g., physical settings, preceding actions). Once a habit is formed, perception of contexts triggers the associated response without a mediating goal. Nonetheless, habits interface with goals. Constraining this interface, habit associations accrue slowly and do not shift appreciably with current goal states or infrequent counterhabitual responses. Given these constraints, goals can (a) direct habits by motivating repetition that leads to habit formation and by promoting exposure to cues that trigger habits, (b) be inferred from habits, and (c) interact with habits in ways that preserve the learned habit associations. Finally, the authors outline the implications of the model for habit change, especially for the self-regulation of habit cuing.