白鹤道人的故事

梁武帝天监初年,有一位道人,世人不知其何许人也,更不知其尊姓大名,因常驾白鹤云游天下,故人们尊称日白鹤道人.据<潜山县志·仙释传>记载:他周览各地名山大川,礼拜全国三十六洞天、七十二福地.一天,慕名来到天柱山,朝谒第十四洞天、第五十七福地.见天柱山山体雄伟,气势磅礴,高入苍穹,云飞雾绕,神气氤氲,遂萌生在山中结庐炼修之意.     

Activation of amygdaloid PKC pathway is necessary for conditioned cues-provoked cocaine memory performance

Drug-associated cues are critical in reinstating the drug taking behavior even during prolonged abstinence and thus are thought to be a key factor to induce drug craving and to cause relapse. Amygdaloid complex has been known for its physiological function in mediating emotional experience storage and emotional cues-regulated memory retrieval. This study was undertaken to examine the role of basolateral nuclei of amygdala and the intracellular signaling molecule in drug cues-elicited cocaine memory retrieval. Systemic anisomycin treatment prior to the retrieval test abolished the cues-provoked cocaine conditioned place preference (CPP) memory. Likewise, a similar blockade of cues-provoked cocaine CPP performance was achieved by infusion of anisomycin and cycloheximide into the basolateral nuclei of amygdala before the test. Intra-amygdaloid infusion of H89, a protein kinase A inhibitor, or U0126, a MEK inhibitor, did not affect retrieval of the cues-elicited cocaine CPP memory. In contrast, intra-amygdaloid infusion of NPC 15437, a PKC inhibitor, abolished the cues-elicited cocaine CPP expression, while left the memory per se intact. Intra-amygdaloid infusion of NPC 15437 did not seem to affect locomotor activity or exert observable aversive effect. Taken together, our results suggest that activation of PKC signaling pathway and probably downstream de novo protein synthesis in the basolateral nuclei of amygdala is required for the cues-elicited cocaine memory performance. However, temporary inhibition of this signaling pathway does not seem to affect cocaine CPP memory per se.     

Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system

While serotonin (5-HT) may impair learning and memory, exercise has been reported to improve them. Whether chronic exercise can facilitate fear memory via regulating the serotonin system is unknown. We examined the effects of 4-week treadmill exercise training on levels of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), the protein expression of its receptor 5-HT_1A and transporter in the amygdala, hippocampus and prefrontal cortex of male Sprague–Dawley rats. Our results demonstrated that treadmill exercise (1) improved the passive avoidance learning performance; (2) decreased the 5-HT level in the hippocampus; (3) decreased the expression of 5-HT_1A receptor in the amygdala without altering the transporter expression. Moreover, pretreatment with 0.1 mg/kg 8-hydroxy-di-n-propylamino tetralin, a selective 5-HT_1A receptor agonist, impaired the passive avoidance performance and completely abolished the exercise-enhanced fear memory. Our results suggest that down-regulation of the 5-HT system in the limbic system, i.e., the reduction of the hippocampus 5-HT content and the amygdala 5-HT_1A receptor expression, may be involved in the exercise-enhanced fear memory.     

康德关于纯粹实践理性方法论的思想

文章立足于分析康德对“客观的德性法则如何在主观上也成为实践的”这一问题的回答,梳理了康德的纯粹实践理性的方法论思想,提出了两个步骤的理论：判断力的练习与自由的意识;并分析了方法论与实践理性批判的分析论在方法上的统一。康德认为这一方法论思想对道德生活与道德培育具有重要的意义,尤其是自由的意识以及对自己的敬重是道德教育的立足点,因为它们也是人在内心防止心灵的腐败与堕落的惟一守卫者。     

马克思人的精神解放的理论实质及现代价值

社会越是向前发展,人们实践越是复杂,时代变革越是强烈,就越需要哲学,因为哲学是一个时代最精致、最深刻的思想.今天中国人需要的是解放的哲学,是解放中国人精神的哲学.人的精神解放既是马克思人学理论的重要内容,也是马克思人的解放理论的重要组成部分.马克思人的解放理论是以人的自我解放为历史前提,以人的生活境况为现实依据,以人的精神解放为最终目标和检验标准的.那么,马克思关于人的精神解放理论的实质、路径以及研究这一理论的重大价值又是什么?笔者循着这一研究思想在本文展开探讨.     

持续学习组织文化研究

学习型组织是目前管理领域中组织变革的主流方向之一,本研究指出塑造持续学习之组织文化是创建学习型组织的重要内容。通过自编问卷,对国营与非国营两种性质不同群体员工的调研,初步确定持续学习组织文化的结构维度。研究还考察了组织文化和一些组织行为以及实际的学习行为之间的关系。     

中学生问题解决策略的基本特征研究

实验通过人—机界面,对中学生解决几何问题策略的基本特征进行探讨。对学习成绩优、差学生,在解决问题的程序上和解决问题结果的正确与错误上的差异比较后显示：学习成绩优、差学生在解决问题的程序上,尤其在问题解决的思考推理方向上没有类似专家和新手之间的显著差异;学习成绩的优、差对解决问题结果的正确与错误上具有直接的影响;问题解决规则的选择对问题解决过程具有间接影响;对问题解决规则的掌握对问题解决的结果具有重要影响。     

结构对称汉字识别的加工机制——部件识别的实验研究

从部件加工的角度设计了两个实验,分别运用部件启动作业和部件启动再认范式,考察了结构对称汉字识别的加工特点。结果发现:在部件加工层面也存在着显著的结构对称效应。即同一个部件,作为结构对称字的构成部件的启动效应明显大于它作为非对称字的构成部件的启动效应;作为结构对称字的构成部件被识别的反应时和错误率均显著地小于它构成非对称字时被识别的反应时和错误率。这意味着结构对称汉字中的部件(或笔画)比非对称汉字中的同样部件(或笔画)具有加工优势。显示出多层次的结构对称效应。     

Culture and perceptions of self—other similarity

In testing possible cultural effects of the use of the self as an habitual reference point to which others are compared, we expected that: (a) individualistic participants (i.e., those who give priority to personal goals) would rate self—other similarity higher when asked “How similar is X to you?” than when asked “How similar are you to X?”, whereas nondirectional similarity judgements (“How similar are these two people?”) would resemble the former directional comparison; (b) collectivistic participants (i.e., those who give priority to in‐group goals) would show a weaker or, possibly, reversed pattern, especially using in‐group comparison others. Neither hypothesis was upheld. However, the individualists perceived the in‐group to be relatively more similar to themselves as compared to the collectivists. This difference cannot be explained by response bias, status asymmetry, or role differentiation. We propose an explanation in terms of the differential relationship between self and other representations for people from collectivist versus individualist cultures.