A Pilot Study to Assess the Feasibility of a Multicenter Cluster Randomized Trial for the Management of Asymptomatic Persons with a Thrombophilia

There is controversy whether asymptomatic first-degree relatives (FDRs) of patients with venous thromboembolism (VTE) and thrombophilia should be screened, followed, and prescribed prophylaxis during risk periods. We recruited consecutive probands with idiopathic VTE and thrombophilia from our thrombosis clinics. Those FDRs with thrombophilia were randomized in family clusters to receive one-time verbal counseling and no organized follow-up or counseling, educational material, reminder aids and follow-up. Only 203 of 1,129 FDRs were eligible and consented. Dropouts were common; 1 FDR (1.7%) developed VTE. VTE risk, ability to treat and prevent were underestimated by the participants. Patients with VTE and thrombophilia and their FDRs are often not interested in thrombophilia testing. Despite education to inform their knowledge, interest and follow-up were less than ideal. The question of the best educational approach in these patients remains unanswered. The value of testing and following asymptomatic carriers of probands with VTE and thrombophilia remains unknown.     

A mutual acculturation model of multicultural campus climate and acceptance of diversity

This study examines the relationship between college students' perceptions of their campus' multicultural climate and their acceptance of racial/ethnic diversity. A two-mediator model, based on acculturation principles, was successfully fit to survey data from 434 college students of diverse racial/ethnic heritage. Results showed that valuing positive interactions with members of ethnocultural groups other than one's own is a positive mediator and strength of ethnocultural identity is a (much less important) negative mediator of the relationship between student perceptions of multicultural campus programming and personal acceptance of diverse racial/ethnic groups. Furthermore, each mediator independently contributed to the prediction of such acceptance. Overall, the model accounts for about 25% of the variance in acceptance of diversity and was a better fit to the data than a reverse path model. Follow-up analyses, separately by ethnic group, showed that perceptions of campus programming predicted acceptance of diversity for the White subsample, but not for the Latino subsample. Nevertheless, the two acculturation-related constructs were important for both groups, with the model accounting for 28% and 24% of their respective variances in acceptance of diversity. Practical implications are drawn.     

False reports of childhood events in appropriate interviews

The present study employed the “parental misinformation & CloseCurly ” paradigm to examine whether individuals report false events from their childhood even when they are interviewed in an appropriate manner by a trained interviewer. Each participant was interviewed on three occasions. By the final interview, one participant produced a “full & Close Curly ” report, and six participants produced “partial & Close Curly ” reports, of childhood events that did not occur. Although participants reported perceiving greater pressure to report the false events than the real events, independent judges' ratings of social pressure in the interviews did not differ as a function of what type of event participants were being asked about. Participants also reported higher confidence in their parents', compared to their own, recall of events from their childhood. False reports were also positively correlated with scores on both the full and the revised versions of the Dissociative Experiences Scale, and negatively correlated with score on the Self-Monitoring scale. These results indicate that, despite being interviewed in an appropriate manner by a trained interviewer, some participants will falsely report events from their childhoods.     

A multi-dimensional measure of worry: Development and preliminary validation of the anxious thoughts inventory

This paper reports the development of a dispositional self-report measure of multiple dimensions of generalised worry. Factor analyses demonstrated a replicable three factor structure indicating that this measure of worry comprises three basic dimensions: social worry, health worry, and meta-worry. The first two factors reflect different content dimensions whereas the meta-worry factor consists of both content and process dimensions of worry. Individual differences in subscale scores show moderate stability over time, and the subscales possess good psychometric properties. Significant correlations were found between worry subscales and personality dimensions of self-consciousness and EPI scores. The role of multi-dimensional measurement in the exploration of worry is discussed.     

Perceived Risk Following Melanoma Genetic Testing: A 2-Year Prospective Study Distinguishing Subjective Estimates from Recall

A major goal of predictive genetic testing is to alert people to their risk before illness onset; however, little is known about how risk perceptions change following genetic testing and whether information is recalled accurately over time. In the United States, a CDKN2A/p16 mutation confers 76 % lifetime risk of melanoma. Following genetic counseling and test reporting, subjective risk estimates and recall of counselor-provided risk estimates were assessed 5 times over the next 2 years among 60 adult members of 2 extended CDKN2A/p16 kindreds. No sustained changes from baseline in risk perceptions were reported. Unaffected carriers (n?=?15) consistently reported significantly lower subjective risk estimates (46 %) than they were actually given (76 %, p?<?0.001) or recalled having been given (60 %, p?<?0.001). Noncarriers’ (n?=?27) risk estimates decreased following results disclosure, but rebounded, with both subjective and recalled estimates subsequently exceeding what they were told by the counselor (both ps?<?0.001). Affected carriers’ (n?=?18) risk estimates for developing a new melanoma corresponded well to counselor-provided information (p?=?0.362). For all 3 patient groups, results were consistent across multiple risk measures and remained similar when demographic, phenotypic, and baseline behavioral contributors to melanoma risk were statistically controlled. These findings are consistent with other studies of risk perception, but additional studies of more diverse populations are needed to understand the reasons behind both the persistence of initial risk estimates and their divergence from information provided by the counselor during genetic counseling. Additionally, determining whether holding subjective risk perceptions that differ from counselor-provided information ultimately affects adherence to management recommendations will help guide the presentation of risk information in genetic counseling practice.     

Viewing the MMPI–2–RF Structure Through the Personality Psychopathology Five (PSY–5) Lens

Ben-Porath and Tellegen (2008) recommend organizing MMPI–2–RF scale interpretive information around 3 broad topics, emotional/internalizing dysfunction, thought dysfunction, and externalizing/behavioral dysfunction, and 3 additional topics labeled somatic complaints, interpersonal functioning, and interests. That organization is based primarily on structural analyses of the Restructured Clinical (RC) scales. This study reviewed the MMPI–2–RF's scale structure when the Personality Psychopathology Five (PSY–5) scales are included. Principal axis factor analyses with oblique rotation were conducted on the Restructured Clinical, PSY–5, and Special Problem (SP) scales in 2 samples, by gender. One sample was an outpatient community health center, the other a large, metropolitan inpatient psychiatric facility. The 6-factor solution evidenced each of the PSY–5 constructs plus a general somatic concerns factor. Implications of this solution in comparison to the 3-factor organizing structure recommended by Ben-Porath and Tellegen are discussed.     

New and updated tests of print exposure and reading abilities in college students

The relationship between print exposure and measures of reading skill was examined in college students (N = 99, 58 female; mean age = 20.3 years). Print exposure was measured with several new self-reports of reading and writing habits, as well as updated versions of the Author Recognition Test and the Magazine Recognition Test (Stanovich & West, 1989). Participants completed a sentence comprehension task with syntactically complex sentences, and reading times and comprehension accuracy were measured. An additional measure of reading skill was provided by participants' scores on the verbal portions of the ACT, a standardized achievement test. Higher levels of print exposure were associated with higher sentence processing abilities and superior verbal ACT performance. The relative merits of different print exposure assessments are discussed.     

Why did I right that? Factors that influence the production of homophone substitution errors

Despite considerable research on language production errors involving speech, little research exists in the complementary domain of writing. Two experiments investigated the production of homophone substitution errors, which occur when a contextually appropriate word (e.g., beech) is replaced with its homophone (e.g., beach tree). Participants wrote down auditorily presented sentences containing dominant or subordinate homophones. Homophones were preceded by a lexical prime that overlapped in phonology and orthography (e.g., teacher) or only orthography (e.g., headmaster) with the target homophone. Results showed more substitution errors when the context elicited a subordinate homophone than when it elicited a dominant homophone. Furthermore, both types of primes equivalently increased production of homophone errors relative to control words (e.g., lawyer), suggesting that only orthographic overlap between the prime and target was necessary to influence errors. These results are explained within dual-route models of spelling, which postulate an interaction between lexical and sublexical routes when spelling.