5-HTTLPR,HTR1A,and HTR2A cumulative genetic score interacts with mood reactivity to predict mood-congruent gaze bias

Genetic variation within the serotonin system has been associated with biased attention for affective stimuli and, less consistently, with vulnerability for major depressive disorder. In particular, 5-HTTLPR, HTR1A (rs6295), and HTR2A (rs6311) polymorphisms have been linked with biased cognition. The present study developed a serotonergic cumulative genetic score (CGS) that quantified the number of risk alleles associated with these candidate polymorphisms to yield a single CGS. The CGS was then used to model genetic influence on the relationship between reactivity to a negative mood induction and negatively biased cognition. A passive-viewing eye-tracking task was administered to 170 healthy volunteers to assess sustained attention for positive, dysphoric, neutral, and threatening scenes. Participants were then induced into a sad mood and readministered the passive-viewing task. Change in gaze bias, as a function of reactivity to mood induction, was the primary measure of cognitive vulnerability. Results suggest that, although none of the individual genes interacted with mood reactivity to predict change in gaze bias, individuals with higher serotonin CGS were significantly more likely to look toward dysphoric images and away from positive images as mood reactivity increased. These findings suggest that a CGS approach may better capture genetic influences on cognitive vulnerability and reaffirm the need to examine multilocus approaches in genomic research.     

Adherence, body mass index, and depression in adults with type 2 diabetes: the mediational role of diabetes symptoms and self-efficacy.

OBJECTIVE: Evidence indicates that depression is linked to the development and worsening of diabetes, but the mechanisms underlying this link are not well understood. The authors examined the hypothesis that diabetes-related symptoms mediate the effect of both behavioral adherence and body mass index (BMI) on depression. In addition, they examined whether a prior finding that self-efficacy mediates the effect of behavioral adherence and BMI on depression would replicate with a larger sample size (W. P. Sacco, K. J. Wells, C. A. Vaughan, A. Friedman, S. Perez, & R. Morales, 2005). Also, the relative contributions of diabetes-related symptoms and self-efficacy to depression were evaluated. DESIGN AND PARTICIPANTS: Cross-sectional design involving adults diagnosed with Type 2 diabetes (N = 99). MAIN OUTCOME MEASURES: The primary outcome measure was depression (Patient Health Questionnaire: Nine Symptom Depression Checklist). Predictors of depression were diet and exercise adherence (Summary of Diabetes Self-Care Activities Questionnaire), diet and exercise self-efficacy (Multidimensional Diabetes Questionnaire), diabetes symptoms (Diabetes Symptom Checklist), and BMI (based on height and weight data from medical records). RESULTS: Path and mediation analyses indicated that adherence and BMI each contributed to depression indirectly, via their effects on self-efficacy and diabetes-related medical symptoms. CONCLUSION: Results provide evidence consistent with two independent pathways by which BMI and adherence could increase depression in people with Type 2 diabetes. The first pathway indicates that the effects of higher BMI and poor adherence on depression are mediated by lower self-efficacy perceptions. The second pathway indicates that the effect of higher BMI on depression is mediated by increased diabetes symptoms.     

Relationships between anxiety,self-consciousness,and cognitive failure

Abstract

Two studies of correlates of the Cognitive Failures Questionnaire (CFQ) are reported. The first study tested for empirical personality correlates of the CFQ; the second study investigated the role of self-consciousness as a possible mediator of the association betyeen cognitive failures and stress vulnerability. Study 1 (n = 60) showed significant correlations between CFQ score and several 16PF primary and secondary traits, notably anxiety. Study 2 (n = 100) used multiple regression to verify the hypothesis that the positive association between CFQ score and anxiety is at least partially mediated by individual differences in self-consciousness. It is concluded that high CFQ subjects are vulnerable to stress because self-attentional processing disrupts their coping strategies.     

Inconsistent Discipline as a Mediator Between Maternal Distress and Aggression in Boys

The current study examines inconsistent discipline as a mediator in the association between maternal distress and child aggression and attention problems. Participants were 215 boys, ranging in age from 9 to 12 years, and their mothers. Mothers provided self-report data on socioeconomic status (SES), parenting stress, maternal distress (depression and anxiety/somatization), and use of parenting practices. They also rated their sons' levels of aggression and attention problems. Of five parenting practices measured, inconsistent discipline was most clearly related to the maternal and child variables of interest. Regression analyses indicated that inconsistent discipline partially mediated the relation between maternal distress and child aggression, when controlling for SES and stress, whereas the mediating role of inconsistent discipline in the association between maternal distress and attention problems was not supported. The different pattern for attention problems, which also includes nondisruptive behaviors, suggests that this mediation may be specific to certain types of child behavior. Given that aggressive behaviors in childhood often lead to more serious delinquency in adolescence, these findings are important for informing prevention and intervention efforts. The need for future research to examine other mediators also is discussed.     

Inference making and linking both require thinking: Spontaneous trait inference and spontaneous trait transference both rely on working memory capacity

Past research suggests that spontaneous trait inference (STI) and spontaneous trait transference (STT) may reflect different cognitive processes, the former being inferential and the latter associational. The present research was designed to explore whether either or both of these processes involve thinking that occupies cognitive capacity. Four studies suggest that reductions in available cognitive capacity reduce both STI and STT effects, both on measures of savings in relearning (which reflect the strength of trait associations with a person) and on trait ratings measures (which reflect the strength of trait inferences made about a person). Similar results were obtained using an individual difference measure of cognitive capacity. Although these results suggest that STI and STT are similar, in that both exhibit interference from reductions in cognitive capacity, other results, such as halo effects in trait ratings, support previous assertions that their underlying processes are distinct.     

Personality and Reaction Time after Sleep Deprivation

The relationship between reaction time and both state and trait personality variables was investigated in 37 participants after 30 h of sleep deprivation. Regression analyses suggested that endorsement of greater Novelty Seeking, anger/hostility, and depression/dejection, and less confusion, was associated with greater reaction time declines on one Multi-Attribute Task Battery index after sleep deprivation. Further, greater Novelty Seeking and depression/dejection, and less vigor/activity, was associated with greater reaction time declines after sleep deprivation on another Multi-Attribute Task Battery index. Additional correlational analyses indicated that better reaction times were associated with greater Novelty Seeking and lower anger/hostility prior to sleep deprivation, and less confusion/bewilderment following sleep deprivation. Findings suggest that both state and trait personality variables are associated with reaction time performance following sleep deprivation.     

Psychometric Validation of the Preschool Outcome Questionnaire: A Preschool Treatment Outcome Instrument

Developing normed treatment outcome measures is important to research addressing treatment effectiveness and to improved clinical care. The Preschool Outcome Questionnaire (POQ) is a new measure designed for use with preschool children aged two to six. Designed in collaboration with parents and clinicians, the POQ is brief, easy to administer, score and interpret. This study reports on the instrument’s psychometric evaluation, contains preliminary normative data, and provides a clinical cut-off and a reliable change index to facilitate clinical use of the instrument. Results show that the POQ has acceptable test–retest and internal reliability, concurrent validity and criterion validity. Importantly, results also show that the instrument is sensitive to clinically relevant change. Clinical implications are discussed as well as suggestions for further research.     

The Theory of Reasoned Action as a Model of Children's Health Behavior1

This research examined the applicability of the theory of reasoned action to school‐age children. Using structural equation modeling, we longitudinally modeled children's attitudes, norms, intentions, and behavior with regard to drinking alcohol. Respondents were 1,061 children attending public schools in the northwestern United States. Attitude, norms, and intentions (measured when the children were in 6th, 7th, 8th, and 9th grades) were used to predict alcohol use 1 year later. Two modifications of the model improved the overall fit at each grade level: separating attitude into 2 dimensions (positive and negative), and adding a path from social norm to behavior. The theoretical and practical implications of these results are discussed.