抑郁障碍和焦虑障碍治疗的神经心理机制——脑成像研究的ALE元分析

抑郁障碍和焦虑障碍是两种最常见的精神障碍。使用激活似然估计(activation likelihood estimation,ALE)元分析对抑郁和焦虑障碍患者治疗后出现的一致脑区激活改变进行评估,并考察不同条件下这一改变的差异。研究共纳入25篇文献,结果发现:(1)抑郁和焦虑障碍接受治疗后,枕下回(inferior occipital gyrus,IOG)等脑区激活增加;豆状核(lentiform nucleus)等激活减少。(2)a.心理治疗产生的脑激活改变为豆状核活动的减少;药物治疗则在于扣带回(cingulate gyrus)等活动增加,而楔前叶(precuneus)等活动减少。b.任务下成像治疗后激活增加的脑区为扣带回等,减少的脑区为楔前叶等;静息下成像,治疗后枕下回等激活增加,额内侧回(medial frontal gyrus,MFG)等激活减少。c.抑郁障碍治疗后的脑激活变化为扣带回等活动增加,楔前叶等活动减少;焦虑障碍在于前扣带回/额内侧回(anterior cingulate/MFG)活动减少。研究表明治疗会给抑郁和焦虑障碍带来一致的脑区激活改变;治疗方法、成像状态和障碍类型不同,治疗后脑区激活改变也存在差异。     

The relationship of perfectionism with psychological symptoms in cancer patients and the contributing role of hyperarousability and coping

Objective: Significant levels of anxiety, depression and insomnia symptoms are found in cancer patients. Perfectionism, arousability and coping have been associated with these psychological symptoms in the general population but their role among cancer patients remains to be assessed. This study examined the longitudinal relationships between perfectionism and psychological symptoms (anxiety, depression, insomnia), and the intermediate role of the arousability trait and coping strategies.

Design: Participants (N = 853) completed the Multidimensional Perfectionism Scale, the Coping with Health Injuries and Problems questionnaire and the Arousal Predisposition Scale at the perioperative period (T1), and the Hospital Anxiety and Depression Scale and the Insomnia Severity Index two months later (T2).

Results: Higher levels of perfectionism (T1) were correlated with greater symptoms of anxiety, depression and insomnia (T2). Moderated mediation models indicated that arousability contributed to the association of perfectionism with all symptoms, with stronger associations found in men than in women. Coping was a significant pathway between perfectionism and anxiety, with associations of a comparable magnitude across sexes.

Conclusion: If these results are replicated by future longitudinal studies, they would suggest that perfectionist cancer patients are at a higher risk of experiencing psychological symptoms, partly through their hyperarousability and the coping strategies they use.     

Effects of loading modes on densification efficiency of spark plasma sintering: sample study of zirconium carbide consolidation

Theoretical studies on the densification kinetics of the new spark plasma sinter-forging (SPS-forging) consolidation technique and of the regular SPS have been carried out based on the continuum theory of sintering. Both modelling and verifying experimental results indicate that the loading modes play important roles in the densification efficiency of SPS of porous ZrC specimens. Compared to regular SPS, SPS-forging is shown to be able to enhance the densification more significantly during later sintering stages. The derived analytical constitutive equations are utilised to evaluate the high-temperature creep parameters of ZrC under SPS conditions. SPS-forging and regular SPS setups are combined to form a new SPS hybrid loading mode with the purpose of reducing shape irregularity in the SPS-forged specimens. Loading control is imposed to secure the geometry as well as the densification of ZrC specimens during hybrid SPS process.     

邻里环境、父母监控和不良同伴交往对青少年问题行为的影响

父母监控和不良同伴交往是影响青少年问题行为的重要因素,同时这种影响又离不开其所处邻里环境的共同作用。本研究通过对2个区县7所学校47个班2188名初一学生及其家长的问卷调查,探讨了邻里环境指标、父母监控和不良同伴交往影响青少年问题行为的路径。结果发现：（1）邻里犯罪能够直接预测青少年的问题行为;同时,邻里犯罪、邻里凝聚与混乱还能够通过父母监控和不良同伴交往为中介,进而影响青少年问题行为;（2）在纳入邻里环境影响条件下,父母监控与不良同伴交往对于青少年问题行为的影响具有显著的交互作用;随着父母监控的提高,不良同伴交往对青少年问题行为的影响减小;（3）对于男孩而言,邻里犯罪对问题行为、父母监控对问题行为、不良同伴交往对问题行为的预测作用大于女孩。     

生命意义问卷(修订版)在初中生群体中的信效度:留守与非留守学生的比较分析

检验生命意义问卷(修订版)在初中生群体中的信效度,并比较了留守与非留守学生在测量学指标上的差异。采用生命意义问卷(修订版)、超越意义量表、情感调节量表、Rosenberg自尊量表和幸福感指数量表对1300名初中生进行调查,其中有636名留守初中生。探索性因素分析、平行分析和最小平均偏相关分析均表明该量表为双因子结构,验证性因素分析与各类群体拟合良好;与上述效标变量均有显著的正相关;在性别和是否留守学生变量上,个别条目表现出一致性或非一致性条目功能差异;总量表、追寻和拥有意义分量表的δ系数都大于0.9。生命意义问卷(修订版)具有在初中生和留守初中生中均有良好的信效度;可以忽略在性别和是否留守学生变量的条目功能差异;问卷辨识度较高。     

背景线索和认知风格对真实场景中目标搜索影响的眼动研究

采用眼动记录方法,研究背景线索和认知风格对真实场景中目标搜索三阶段的影响。实验以真实的室内场景图片为材料,通过重复呈现整体背景一致或局部背景一致的场景,考察不同场认知风格被试在整体背景线索和局部背景线索条件下在目标搜索各阶段的眼动特征。结果表明,整体背景线索和局部背景线索对目标搜索的启动和确认阶段没有影响,对扫描阶段有促进作用,且整体背景线索效应大于局部背景线索效应,主要体现在能更有效地选择注视区域,在单次注视中获得更多的信息,更迅速地拒绝当前注视区域和计划下一次眼跳;认知风格不影响个体在真实场景目标搜索过程中对背景线索的利用。     

农民工情绪性、弹性和坚韧性特质及其对心理健康的预测作用

采用"中国成年人情绪性量表""中国成年人心理弹性量表""中国成年人坚韧性量表""总体幸福感量表""SCL-10"对559名农民工进行了测试,旨在考察农民工情绪性、坚韧性和弹性特质的负载情况及其对心理健康的预测作用。结果表明,农民工的积极情绪性特质和坚韧性特质的负载量显著高于全国成年人常模,而弹性特质负载量显著低于全国成年人常模;情绪性、坚韧性和弹性特质对于主观幸福感具有显著正向预测作用,而对心理痛苦症状具有显著反向预测作用。     

The glass is not yet half empty: agitation but not <Emphasis Type="Italic">Varroa</Emphasis> treatment causes cognitive bias in honey bees

Honey bees (Apis mellifera) are prone to judge an ambiguous stimulus negatively if they had been agitated through shaking which simulates a predator attack. Such a cognitive bias has been suggested to reflect an internal emotional state analogous to humans who judge more pessimistically when they do not feel well. In order to test cognitive bias experimentally, an animal is conditioned to respond to two different stimuli, where one is punished while the other is rewarded. Subsequently a third, ambiguous stimulus is presented and it is measured whether the subject responds as if it expects a reward or a punishment. Generally, it is assumed that negative experiences lower future expectations, rendering the animals more pessimistic. Here we tested whether a most likely negatively experienced formic acid treatment against the parasitic mite Varroa destructor also affects future expectations of honey bees. We applied an olfactory learning paradigm (i.e., conditioned proboscis extension response) using two odorants and blends of these odorants as the ambiguous stimuli. Unlike agitating honey bees, exposure to formic acid did not significantly change the response to the ambiguous stimuli in comparison with untreated bees. Overall evidence suggests that the commonest treatment against one of the most harmful bee pests has no detrimental effects on cognitive bias in honey bees.     

自我欺骗:为了调节个体心理状态

本研究旨在探索自我欺骗的研究方法、产生的原因和认知机制,以及这一领域中有待解决的新问题。近期研究发现:基于自我欺骗产生的动机特点,主要存在三类不同的定义方式,大多数心理学家是基于第三类定义来研究自我欺骗。研究方法上,适用性较强的自欺问卷是自欺性提升量表(SDE),操作性较强的经典实验范式是点追踪任务。在认知过程的任一阶段中,调节心理状态是个体产生自我欺骗的直接动机,改变个体的心理状态或对事物的模糊感知可能阻止个体自我欺骗的产生。未来应从如何调节个体心理状态的角度探讨和研究自我欺骗,能够利用点追踪任务,结合ERPs或fMRI技术为之后研究自欺产生的具体阶段、认知机制以及神经机制提供实证研究基础。     

重解动作理解的“戈尔迪之结”:镜像神经元祛魅

"动作理解"一直被视为镜像神经元功能最为保守的假设,同时也是证据链最为强健的领域之一,但其概念内涵却始终如同古希腊神话中的"戈尔迪之结"一般没有得到厘清。目前,动作理解的紧缩解释正在面临严峻的挑战。来自实验室检验与哲学拷问的证据倾向于认为,镜像神经元活动构成动作理解的观点是一种"循环论证",前者至多只能算作产生动作理解的附带原因,而不是必要与充分原因。将广义的动作分成运动、运动动作与运动动作链可以有效地澄清实现理解不同层次的动作需要具备哪些条件。回应质疑并为辩护自身立场指明前进方向,是重解动作理解"戈尔迪之结"的起点,将对镜像神经元的科学祛魅产生奠基性的影响。