体外循环所致炎性肺损伤机制及保护进展

肺损伤是体外循环心内直视手术的主要并发症之一.肺损伤的机制十分复杂,主要是全身炎性反应和缺血/再灌注损伤所致.肺保护的方法多种多样,其目的是降低全身炎性反应,减轻或避免缺血/再灌注损伤.本文探讨体外循环肺损伤的机制和保护进展.     

西美尔关于现代宗教形而上学重建的构想——从外在的超验对象到内在的生命品性

在"生命"反抗"形式"的现代性文化境遇下,传统宗教也发生了现代转化,即宗教信仰成为宗教生命冲动的表达,这既使"宗教"由外在建构走向活生生的内在的"宗教性"生存,也面临着失去确定的形而上学目标的现代性困境。走出这一困境只能通过一条内在的精神的途径,就是将"灵魂的宗教性存在本身"视为"形而上学的价值",由此跳出主体需要和客体对象之间的二元对立,故而,确立起灵魂存在的形而上学宗教性的自觉意识和内在信仰是宗教现代性重建的关键。     

靶向药物不良反应的认识与思考

新的靶向药物出现提高了抗癌疗效,降低了毒性,使转移性恶性肿瘤患者从治疗中获益。靶向药物耐受性好,通常出现轻微或中度的毒副反应。尽管大多数不良反应是可以得到迅速处理的,但是严重的甚至危及生命的不良反应仍能够发生。因此,为更好地指导临床实践工作,该文综述了实体瘤治疗中常用靶向药物的主要不良反应和安全数据,并按照药物的作用靶...     

精神科住院患者团体心理治疗准备性会谈与治疗后访谈初探

精神科住院患者团体心理治疗较门诊患者团体心理治疗存在临床情境的特殊性,本研究探索将准备性会谈与治疗后访谈纳入治疗计划,治疗前向患者普及住院治疗、心理治疗的知识,澄清团体心理治疗的形式、目标、内容,了解患者对团体心理治疗的疑问、期望,允许患者做出是否参加治疗的决定,并在治疗后的访谈中强化疗效因子.     

彩色背景下的颜色突显研究

颜色突显是指在与视觉搜索任务有关的视觉显示中,采用颜色突出显示多个项目中的目标项目,从而提高视觉搜索效率的一种方法或技术。本文采用视觉搜索任务,以正确率和反应时为指标对单彩色和复杂彩色背景下不同颜色突显的视觉搜索绩效进行了研究。结果表明：（1）在单彩色背景和复杂彩色背景下,颜色突显条件视觉搜索绩效显著优于非突显条件;（2）在浅蓝或浅绿的单彩色背景下,四种颜色突显绩效中,红色突显绩效最好,紫色最差,而在随机彩色背景和复杂彩色背景下,颜色突显绩效差异并不显著;（3）在彩色背景下的颜色突显绩效会受到干扰数字的颜色的影响,其中在单色和随机彩色背景下,干扰目标颜色为黑色时的视觉搜索绩效优于干扰目标颜色为白色时的情景,而在自然彩色背景下,这种视觉搜索优势并不存在。     

意识锚定加工对潜在锚定加工的影响

潜在锚定效应是指阈限下的启动锚定数字导致的锚定效应现象。本研究通过2个实验探讨了意识锚定加工对潜在锚定加工的影响。实验一考察了意识层面的外在锚对潜在锚定效应产生的影响,实验二则进一步探讨了意识层面的自发锚对潜在锚定效应的影响。实验一发现,在不存在外在锚时高锚与低锚的估计有显著性差异;实验二发现,在不存在自发锚时高锚与低锚的估计有显著性差异。研究结果表明,外在锚定加工和自发锚定加工的效应都强于潜在锚定加工。     

中国道路与社会主义核心价值体系

新中国成立六十多年特别是改革开放三十多年来,社会主义革命、建设和改革取得巨大成就的关键在于开创了一条既坚持科学社会主义的基本原则,又根据我国实际和时代特征赋予其鲜明的中国特色的"中国道路".社会主义核心价值体系正是在"中国道路"不断探索、发展和完善的过程中形成的,体现了中国特色社会主义道路的本质要求,在思想和实践中引领了"中国道路"的发展.     

仪式过程与符号象征——索伦鄂温克火神祭祀仪式的田野研究

本文立足于对索伦鄂温克人岁时仪式中火神祭祀仪式的田野调查资料,借鉴了范·杰内普和特纳的仪式研究理论及方法,从象征的角度分析了火神祭祀的仪式过程、仪式结构与秩序,从而描述仪式所表达的深层意义:有形世界与无形世界并非毫不相干,人也并不总在被动地接受神的安排,神秘甚至是危险的世界在仪式中变得可以接触。更为重要的是,对于仪式的参与者来说,一切行为都是可以解释的,而不是毫无理性地随意而为。     

Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning

The adenosine A(2A) receptor (A(2A)R) is highly enriched in the striatum where it is uniquely positioned to integrate dopaminergic, glutamatergic, and other signals to modulate cognition. Although previous studies support the hypothesis that A(2A)R inactivation can be pro-cognitive, analyses of A(2A)R's effects on cognitive functions have been restricted to a small subset of cognitive domains. Furthermore, the relative contribution of A(2A)Rs in distinct brain regions remains largely unknown. Here, we studied the regulation of multiple memory processes by brain region-specific populations of A(2A)Rs. Specifically, we evaluated the cognitive impacts of conditional A(2A)R deletion restricted to either the entire forebrain (i.e., cerebral cortex, hippocampus, and striatum, fb-A(2A)R KO) or to striatum alone (st-A(2A)R KO) in recognition memory, working memory, reference memory, and reversal learning. This comprehensive, comparative analysis showed for the first time that depletion of A(2A)R-dependent signaling in either the entire forebrain or striatum alone is associated with two specific phenotypes indicative of cognitive flexibility-enhanced working memory and enhanced reversal learning. These selective pro-cognitive phenotypes seemed largely attributed to inactivation of striatal A(2A)Rs as they were captured by A(2A)R deletion restricted to striatal neurons. Neither spatial reference memory acquisition nor spatial recognition memory were grossly affected, and no evidence for compensatory changes in striatal or cortical D(1), D(2), or A(1) receptor expression was found. This study provides the first direct demonstration that targeting striatal A(2A)Rs may be an effective, novel strategy to facilitate cognitive flexibility under normal and pathologic conditions.     

Emotional reactions to scandals: When does moral character make a difference?

A scandal can evoke public outrage when it is widely publicized and involves an individual who is perceived to have a high level of cultural representativeness. Two experiments showed that when the scandalous target's moral character was highlighted, emotional responses towards the target were least negative when the scandal was widely circulated and when the target was seen as a representative of his culture. These results suggest that when a cultural symbol is implicated in a widely‐circulated scandal, the negative emotions directed towards the scandalous individual can be alleviated when the public remains confident in his or her commitment to morality.