Switching time between overt and covert speech: Generative attention

Four experiments investigated a new phenomenon: the existence of a very large switching time effect that occurs from rapidly alternating between overt and covert (mouthed) speech. This is referred to as an intensity switching effect, and the time taken for each switch is, in itself, long enough for a spoken or mouthed character (letter or digit) to be produced. In Experiments 1 and 2, the intensity switching effect was shown to be different from the switching that occurs between categories of materials (letters and digits) because it is both much larger and much more resistant to practice effects. The intensity switching effect was also shown to be distinct from a memory load effect, since it holds even for perceptually available lists. In Experiments 3 and 4, the issue of a peripheral vs. a central origin of intensity switching was addressed. Evidence was found for a central origin. In addition, two models -of response intensity representation were contrasted: a symbolic or digital model, with intensity altered by parameter substitution, and an analog model, with intensity represented by a moving pointer on an intensity continuum. The results supported the symbolic model. It is concluded that the intensity switching effect is a measure of control processes at work in altering the intensity parameters of the vocal response system.     

Histamine reverses a memory deficit induced in rats by early postnatal maternal deprivation

Early partial maternal deprivation causes long-lasting neurochemical, behavioral and brain structural effects. In rats, it causes a deficit in memory consolidation visible in adult life. Some of these deficits can be reversed by donepezil and galantamine, which suggests that they may result from an impairment of brain cholinergic transmission. One such deficit, representative of all others, is an impairment of memory consolidation, clearly observable in a one-trial inhibitory avoidance task. Recent data suggest a role of brain histaminergic systems in the regulation of behavior, particularly inhibitory avoidance learning. Here we investigate whether histamine itself, its analog SKF-91844, or various receptor-selective histamine agonists and antagonists given into the CA1 region of the hippocampus immediately post-training can affect retention of one-trial inhibitory avoidance in rats submitted to early postnatal maternal deprivation. We found that histamine, SKF-91844 and the H2 receptor agonist, dimaprit enhance consolidation on their own and reverse the consolidation deficit induced by maternal deprivation. The enhancing effect of histamine was blocked by the H2 receptor antagonist, ranitidine, but not by the H1 receptor antagonist pyrilamine or by the H3 antagonist thioperamide given into CA1 at doses known to have other behavioral actions, without altering locomotor and exploratory activity or the anxiety state of the animals. The present results suggest that the memory deficit induced by early postnatal maternal deprivation in rats may in part be due to an impairment of histamine mediated mechanisms in the CA1 region of the rat hippocampus.     

Feasibility of telephone-based cognitive behavioral therapy targeting major depression among urban dwelling African-American people with co-occurring HIV

Given the burden of depression among those with HIV, and the impact of HIV on urban minority communities there is an urgent need to assess innovative treatment interventions that not only treat depression but do so in a way that allows for increased access to mental health care. This single site, uncontrolled, pilot study sought to determine the feasibility and depression outcomes of an 11-session telephone-based cognitive behavioral therapy intervention delivered over 14 weeks targeting low-income, urban-dwelling, HIV-infected African-American people with major depression. The diagnosis of major depression was made using the Mini International Neuropsychiatric Interview. The primary outcome was the Hamilton Depression Rating Scale (HAM-D) and the secondary outcome was the Quick Inventory of Depression Symptomatology-Self Report (QIDS-SR). Feasibility and satisfaction were also assessed. Assessments occurred at baseline, midpoint and at study conclusion (14 weeks). Fifteen people were screened for the study. Six HIV-infected, low-income, African-American people individuals (five females and one male) were eligible and participated in the study. All patients finished the study. On average, participants completed nine sessions. The sessions lasted for an average of 48 min (SD = 11.5). Compared to mean HAM-D score at baseline (HAM-D = 22.8 (SD = 3.1), the mean HAM-D score was significantly reduced at study conclusion (HAM-D = 9.8 (SD = 7.4); (t (5) = 4.6, p = 0.006); (Cohen d = 1.9)). Compared to the mean QIDS-SR score at baseline (QIDS-SR = 15.5 (SD = 4.2) the mean QIDS score was significantly reduced at study conclusion (QIDS = 7.0 (SD = 5.4);(t (5) = 3.2, p = 0.02); (Cohen d = 1.3)).The mean satisfaction scores across all participants at post-treatment was 5.7 (SD = 0.3) with of a maximum score of 6. Telephone-based CBT can be delivered to low-income, urban-dwelling ethnic minority HIV-infected people resulting in significant reductions in depression symptoms with high satisfaction. The efficacy of this intervention will be assessed in a planned randomized control trial.     

The Effects of Income Levels and Income Inequalities on Happiness

The standard of living reflected by one’s income and consumption is the primary explanation for the utility or satisfaction of the private consumer. However, empirical evidence very often demonstrates that the level of happiness is not necessarily higher for wealthy people in comparison to the poor. This holds within specific populations of a country, and in macro terms by comparison between the happiness of populations with low and high GDP_ppp per capita. Different research studies have used other economic and social explanatory variables for determining consumer happiness within countries. The present paper adds the new factor of income inequality that affects happiness. It is empirically proved that at extreme values of inequality measured by the Gini index, the effect of happiness is negative regardless of GDP_ppp per capita. However, at the intermediate ranges of the Gini index the effect of changes in the index on happiness is ambiguous. These results are found regardless of the actual values of GDP_ppp per capita.