Antipsychotic dose modulates behavioral and neural responses to feedback during reinforcement learning in schizophrenia

Schizophrenia is characterized by an abnormal dopamine system, and dopamine blockade is the primary mechanism of antipsychotic treatment. Consistent with the known role of dopamine in reward processing, prior research has demonstrated that patients with schizophrenia exhibit impairments in reward-based learning. However, it remains unknown how treatment with antipsychotic medication impacts the behavioral and neural signatures of reinforcement learning in schizophrenia. The goal of this study was to examine whether antipsychotic medication modulates behavioral and neural responses to prediction error coding during reinforcement learning. Patients with schizophrenia completed a reinforcement learning task while undergoing functional magnetic resonance imaging. The task consisted of two separate conditions in which participants accumulated monetary gain or avoided monetary loss. Behavioral results indicated that antipsychotic medication dose was associated with altered behavioral approaches to learning, such that patients taking higher doses of medication showed increased sensitivity to negative reinforcement. Higher doses of antipsychotic medication were also associated with higher learning rates (LRs), suggesting that medication enhanced sensitivity to trial-by-trial feedback. Neuroimaging data demonstrated that antipsychotic dose was related to differences in neural signatures of feedback prediction error during the loss condition. Specifically, patients taking higher doses of medication showed attenuated prediction error responses in the striatum and the medial prefrontal cortex. These findings indicate that antipsychotic medication treatment may influence motivational processes in patients with schizophrenia.     

Resilience Among Women with HIV: Impact of Silencing the Self and Socioeconomic Factors

In the U.S., women account for over a quarter of the approximately 50,000 annual new HIV diagnoses and face intersecting and ubiquitous adversities including gender inequities, sexism, poverty, violence, and limited access to quality education and employment. Women are also subjected to prescribed gender roles such as silencing their needs in interpersonal relationships, which may lessen their ability to be resilient and function adaptively following adversity. Previous studies have often highlighted the struggles encountered by women with HIV without focusing on their strengths. The present cross-sectional study investigated the relationships of silencing the self and socioeconomic factors (education, employment, and income) with resilience in a sample of women with HIV. The sample consisted of 85 women with HIV, diverse ethnic/racial groups, aged 24–65 enrolled at the Chicago site of the Women’s Interagency HIV Study in the midwestern region of the United States. Measures included the Connor-Davidson Resilience Scale -10 item and the Silencing the Self Scale (STSS). Participants showed high levels of resilience. Women with lower scores on the STSS (lower self-silencing) reported significantly higher resilience compared to women with higher STSS scores. Although employment significantly related to higher resilience, silencing the self tended to predict resilience over and above the contributions of employment, income, and education. Results suggest that intervention and prevention efforts aimed at decreasing silencing the self and increasing employment opportunities may improve resilience.     

The Role of Subsidies in Coordination Games with Interconnected Risk

Can subsidies promote Pareto‐optimum coordination? We found that partially subsidizing the cooperative actions for two out of six players in a laboratory coordination game usually produced better coordination and higher total social welfare with both deterministic and stochastic payoffs. Not only were the subsidized players more likely to cooperate (choose the Pareto‐optimum action), but the unsubsidized players increased their expectations on how likely others would cooperate, and they cooperated more frequently themselves. After removal of the subsidy, high levels of coordination continued in most groups with stochastic payoffs but declined in deterministic ones. This carry‐over disparity between the deterministic and stochastic settings was consistent with the economic theories that agents were more likely to keep the status quo option under uncertainty than without uncertainty. Hence, players with stochastic payoffs were more likely to keep the high coordination level (status quo) brought by the subsidy in the previous subsidy session. A post‐game survey also indicated that with stochastic payoffs, players focused on risk reduction. Temporary subsidies promoted lasting coordination because even after subsidy was removed, players still assumed that others players would prefer reduced risks from cooperation. With deterministic payoffs, however, the subsidy might crowd out other rationales for coordination, with many players indicating that the subsidy was the only reason for anyone to cooperate. Hence, the coordination level dropped when the subsidy was removed. Copyright © 2014 John Wiley & Sons, Ltd.     

Methods for Practising Ethics in Research and Innovation: A Literature Review,Critical Analysis and Recommendations

This paper provides a systematic literature review, analysis and discussion of methods that are proposed to practise ethics in research and innovation (R&I). Ethical considerations concerning the impacts of R&I are increasingly important, due to the quickening pace of technological innovation and the ubiquitous use of the outcomes of R&I processes in society. For this reason, several methods for practising ethics have been developed in different fields of R&I. The paper first of all presents a systematic search of academic sources that present and discuss such methods. Secondly, it provides a categorisation of these methods according to three main kinds: (1) ex ante methods, dealing with emerging technologies, (2) intra methods, dealing with technology design, and (3) ex post methods, dealing with ethical analysis of existing technologies. Thirdly, it discusses the methods by considering problems in the way they deal with the uncertainty of technological change, ethical technology design, the identification, analysis and resolving of ethical impacts of technologies and stakeholder participation. The results and discussion of our literature review are valuable for gaining an overview of the state of the art and serve as an outline of a future research agenda of methods for practising ethics in R&I.     

Does intrinsic reward motivate cognitive control? a naturalistic-fMRI study based on the synchronization theory of flow

Cognitive control is a framework for understanding the neuropsychological processes that underlie the successful completion of everyday tasks. Only recently has research in this area investigated motivational contributions to control allocation. An important gap in our understanding is the way in which intrinsic rewards associated with a task motivate the sustained allocation of control. To address this issue, we draw on flow theory, which predicts that a balance between task difficulty and individual ability results in the highest levels of intrinsic reward. In three behavioral and one functional magnetic resonance imaging studies, we used a naturalistic and open-source video game stimulus to show that changes in the balance between task difficulty and an individual’s ability to perform the task resulted in different levels of intrinsic reward, which is associated with different brain states. Specifically, psychophysiological interaction analyses show that high levels of intrinsic reward associated with a balance between task difficulty and individual ability are associated with increased functional connectivity between key structures within cognitive control and reward networks. By comparison, a mismatch between task difficulty and individual ability is associated with lower levels of intrinsic reward and corresponds to increased activity within the default mode network. These results suggest that intrinsic reward motivates cognitive control allocation.     

Memory advantage for produced words and familiar native accents

Our memory is better for words that we have read aloud than for words that we have read silently or have listened to. The present study tested this memory advantage for words with native accent markers that participants were either highly familiar or less familiar. As in previous studies, produced words were subsequently remembered better than listened-to words. In contrast to previous studies that involved a comparison of global foreign accents with standard native accents, in the present study words with highly familiar accent markers were remembered better than words with less familiar accent markers (Experiment 1). The familiar accent advantage was also found when participants could not hear their own productions during the training phase (Experiment 2). When tested with a week delay, produced words were still remembered better than listened-to words, but the advantage for words with familiar accent markers was no longer found (Experiment 3).     

Listening for schwa in academic vocabulary

The schwa sound, as the most frequent in English, is a near constant in words of three syllables or longer in academic texts. As linguistic research has shown, it characteristically recurs in rhythmic alternation with stressed syllables, contributing to a word's distinctive sound shape. The location of strong stress and therefore schwa is often determined by the identity of derivational suffixes. Listening for schwa offers insight into reading and spelling long words, developing phonological and morphological sensitivity, weighing appropriate instruction, and recognizing the complexities of acquiring English multisyllabic words for literate engagement.     

Gender Differences in Escapist Uses of Sexually Explicit Internet Material: Results from a German Probability Sample

The intensity of using sexually explicit internet material (SEIM) is contingent on users’ gender. However, gender differences in the motivations for watching SEIM have not yet been comprehensively explored. Drawing on a representative survey of German internet users, we therefore analyze how women and men use SEIM to satisfy escapist needs. Lower life satisfaction, the lack of a committed relationship, and feelings of loneliness contribute to predicting the frequency of using SEIM among men. Loneliness likewise fosters the consumption of SEIM among women, yet the effect is less pronounced. For female internet users, consumption of SEIM even increases in committed relationships and rather indicates a comparably high level of life satisfaction than dissatisfaction with life circumstances. Gender hence substantially moderates the connection between need structures and the consumption of SEIM.     

Explorations in the Social Construction of Anger

On the basis of the social-constructionist theory of anger, 2 studies were conducted to explore the social rules relating to anger appraisals and anger-related responses. In Study 1, 400 adults were asked about appropriate causes of anger and appropriate anger-related actions. Attribution of blame, impact or severity of harm, and perceived usefulness of becoming angry emerged as the major determinants of appropriate anger. Talking things over with the offender was judged as the most appropriate behavior when angry at someone. In Study 2, 112 adults were presented with vignettes depicting anger-provoking incidents that varied in regard to the nature of the provocation and the nature of the relationship between offender and target. Both factors significantly influenced the perceived appropriateness of anger-intensity and anger-related behavior. Taken together, the results provide evidence for high social consensus regarding the appropriate causes of anger and anger-related actions. However, there were also noteworthy interindividual differences and cross-situational variations in everyday constructions of anger. The implications of the findings for the social-constructionist view of anger are discussed.