Uptake of Cardiac Screening and Genetic Testing Among Hypertrophic and Dilated Cardiomyopathy Families

Cardiomyopathy is a genetically and clinically heterogeneous, life threatening disease which affects people of all ages. Recent guidelines provide recommendations for cardiac screening and genetic testing in at-risk relatives, but the uptake and impact of these measures in the United States is unknown. This is a single institution retrospective study that characterizes the uptake of cardiac screening and genetic testing for relatives of a cohort of 57 probands with hypertrophic (HCM) and dilated cardiomyopathy (DCM) who underwent both clinical evaluation and genetic testing. Cardiac screening was indicated for 302 relatives. One hundred and seventy-three (57 %) completed cardiac screening. Forty of the 57 probands were mutation positive and genetic testing was indicated for 213 relatives. Eighty-four (39 %) completed genetic testing. The uptake of cardiac surveillance was greater than the uptake of genetic testing (p?<?0.0001) among relatives of mutation positive probands. Within the group of at-risk, asymptomatic relatives of probands, cardiac screening and genetic testing were positive in 25 % and 40 % of cases, respectively. These data demonstrate the important role and utility of cascade cardiac screening and genetic testing in the care of patients and families with HCM or DCM. The approach to cardiac screening and genetic testing should be family-specific and requires expertise in the genetics of cardiomyopathy.     

Coping mediates between social support,neuroticism, and depression after earthquake and examination stress among adolescents

Abstract

The objective of this study was to investigate the mediating role of coping strategies in the relationships between neuroticism, social support, and depression in two groups of adolescents: earthquake group and examination group. Adolescents facing earthquake stress (earthquake group, N=219) completed measures of neuroticism, perceived social support, coping strategies, and self-rating depression. Similarly, adolescents facing examination stress (examination group, N=241) completed the same measures. Results indicated that the earthquake group reported more use of secondary control engagement coping, whereas the examination group reported more use of primary control engagement coping. In addition, neuroticism was more strongly associated with coping in earthquake group and coping strategies explained significantly larger part of the relationship between neuroticism and depression. In contrary, perceived social support was more strongly associated with coping in examination group, and coping strategies explained significantly larger part of the relationship between perceived social support and depression.     

Learning Impacts of a Digital Augmentation in a Science Museum

ABSTRACT

This study investigated the effects of using digital augmentation to enhance an exhibit device to influence conceptual understanding about a science topic in a science museum setting. In particular, the study considered how students in Grades 6–8 engaged with the device that was available in both augmented and nonaugmented (control) conditions. Results show increased cognitive (critical thinking) skills when the digital augmentation was present that we hypothesize led to increased conceptual gains. We illustrate how this research contributes to three important areas of need identified in informal science literature: the need for evidence of conceptual and cognitive gains; the need for understanding how digital platforms improve the learning experience; and the need to demonstrate how designed interactive devices may impact higher order skills such as critical thinking and theorizing.     

The cognitive advantage for one’s own name is not simply familiarity: An eye-tracking study

Eye-tracking technique and visual search task were employed to examine the cognitive advantage for one’s own name and the possible effect of familiarity on this advantage. The results showed that fewer saccades and an earlier start time of first fixations on the target were associated with trials in which participants were asked to search for their own name, as compared to search for personally familiar or famous names. In addition, the results also demonstrated faster response times and higher accuracy in the former kind of trials. Taken together, these findings provide important evidence that one’s own name has the potential to capture attention and that familiarity cannot account for this advantage.     

Prevalence and Predictors of Posttraumatic Growth in Accidentally Injured Patients

This study examined prevalence and predictors of posttraumatic growth in 180 accidentally injured patients of mainland China in their convalescence stage, investigating its relationships with demographic and accidental injury variables, personality, posttraumatic stress disorder (PTSD) symptoms, and coping styles. Our results showed that posttraumatic growth (PTG) presented mostly in the domain of Relating to Others and indicated that PTG was significantly related to marital status, educational level, personality, coping styles, and PTSD symptoms. Avoidance of PTSD symptoms, Openness to experience, and positive coping were significant predictors of PTG. The findings emphasize that when promoting PTG of accidentally injured patients, healthcare providers should facilitate patients utilizing personal resources, understand PTG coexists with PTSD symptoms, and adjust interventions based on the coping styles the patients have adopted.     

Integrating visual images and visual percepts across time and space

Recent studies suggest that visual information can be integrated over a relatively long delay (> 1500 ms) to form a more complete representation (image-percept integration). The current studies investigated whether this process can occur between stimuli that differ in their spatial properties. Participants viewed two dot arrays that filled all but one space in a square or rectangular grid when combined, and reported the missing space. The arrays differed either in size or orientation. Performance reached a comparable level as when spatial properties were matched. However, such performance depends on at least two processes. We suggest an early encoding process and a later image formation/spatial attention reallocation process are required. The flexibility of the image-percept integration process suggests a strong mechanism to form more complete or detailed representations over time, even when the retinal size and orientation of the scene may change between successive views.     

Encoding the target or the plausible preview word? The nature of the plausibility preview benefit in reading Chinese

Previous studies have shown that a plausible preview word can facilitate the processing of a target word as compared to an implausible preview word (a plausibility preview benefit effect) when reading Chinese (Yang, Wang, Tong, & Rayner, 2012; Yang, 2013). Regarding the nature of this effect, it is possible that readers processed the meaning of the plausible preview word and did not actually encode the target word (given that the parafoveal preview word lies close to the fovea). The current experiment examined this possibility with three conditions wherein readers received a preview of a target word that was either (1) identical to the target word (identical preview), (2) a plausible continuation of the pre-target text, but the post-target text in the sentence was incompatible with it (initially plausible preview), or (3) not a plausible continuation of the pre-target text, nor compatible with the post-target text (implausible preview). Gaze durations on target words were longer in the initially plausible condition than the identical condition. Overall, the results showed a typical preview benefit, but also implied that readers did not encode the initially plausible preview. Also, a plausibility preview benefit was replicated: gaze durations were longer with implausible previews than the initially plausible ones. Furthermore, late eye movement measures did not reveal differences between the initially plausible and the implausible preview conditions, which argues against the possibility of misreading the plausible preview word as the target word. In sum, these results suggest that a plausible preview word provides benefit in processing the target word as compared to an implausible preview word, and this benefit is only present in early but not late eye movement measures.     

Social support as a mediator of religious involvement and physical and emotional functioning in a national sample of African-Americans

Researchers propose social support as one of the factors that may explain the positive relationship often observed between religious involvement and health outcomes. African-Americans are a population that tends to have higher than average levels of religious involvement and are also disproportionately impacted by most health conditions. The present study sought to determine whether social support mediates the role of religious involvement in physical and emotional functioning and depressive symptoms, among a national probability sample of African-Americans (N = 803). Study participants completed telephone interviews. We used structural equation modelling to test hypotheses based on the theoretical model. Findings suggest evidence for a mediating role of belonging and tangible support in the association between religious behaviours and physical functioning as well as depression. There was no mediational role played by appraisal support, or for emotional functioning. Implications for faith-based health promotion interventions are discussed.     

个人幸福指数-中小学生版(PWI-SC)在中国的适用性——兼与澳洲中学生比较

探讨个人幸福指数-中小学生版(PWI-SC)在中国的适用性以及中澳两国中学生个人幸福指数的跨文化差异。采用PWI-SC施测522名中国中学生、185名澳洲中学生,进行区分度、信度和效度检验,发现该问卷可运用于中国中学生个人幸福指数的调查,个别项目需稍加修改。比较中澳中学生的施测结果,中国中学生的个人幸福指数低于澳洲中学生,中国中学生得分为47-70,澳洲中学生得分为51-72;中国中学生除在个人已有成就项目上得分高于澳洲中学生外,其他方面均较低;中澳两国初中生的个人幸福指数均显著高于高中生,两国初高中生个人幸福指数的差异体现在不同方面;中澳两国中学生个人幸福指数的年龄差异均显著,进一步事后分析发现,两国中学生个人幸福指数的基本趋势均为随年龄增长,个人幸福指数降低,中国15岁中学生的个人幸福指数较高。PWI-SC基本适用于中国中学生;中学生随年龄增长,个人幸福指数降低;中国中学生的个人幸福指数低于澳洲中学生。     

颜色概念的知觉符号表征与命题符号表征

使用启动范式通过两个实验检验颜色概念的表征是知觉符号表征还是命题符号表征.实验l使用显性颜色概念,即颜色词;实验2使用隐性颜色概念,即隐含颜色信息的词.实验结果表明显性颜色概念的表征是知觉符号表征,而隐性颜色概念的表征是命题符号表征.