Effect of multicomponent interventions on caregiver burden and depression: the REACH multisite initiative at 6-month follow-up

Meta-analysis was used to examine pooled parameter estimates of 9 active compared with 6 control conditions of the Resources for Enhancing Alzheimer's Caregiver Health (REACH) project at 6 months on caregiver burden and depressive symptoms. Associations of caregiver characteristics and outcomes were examined. For burden, active interventions were superior to control conditions (p = .022). Also, active interventions were superior to control conditions for women versus men and for caregivers with lower education versus those with higher education. For depressive symptoms, a statistically significant association of group assignment was found for Miami's family therapy and computer technology intervention (p = .034). Also, active interventions were superior to control conditions for Hispanics, nonspouses, and caregivers with lower education. Results suggest interventions should be multicomponent and tailored.     

An Appreciation of Hal Childs' Critique of Historical Jesus Research

Biblical scholars have been exceedingly slow to grasp the implications of the Heisenberg principle, namely, that the observer is always a part of the field being observed, and disturbs that field by the very act of observation. In terms of the interpretive task, this means that there can be no question of an objective view of Jesus as he really was. Objective view; is itself an oxymoron; every view is subjective, from a particular angle of vision. We always encounter the biblical text with interests. We always have a stake in our reading of it. We always have angles of vision that can be helpful or harmful in interpreting texts. Historical writing does not treat reality; it treats the interpreter's relation to it, according to Brian Stock. All history, said the poet Wallace Stevens, is modern history. And historical criticism is a form of criticism of the present, according to Walter Kasper. All that is true, but only partially. For historical criticism can still help us recover an understanding of that past that holds out to us present meaning.     

Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdala of the mouse

The endogenous cannabinoid system has been shown recently to play a crucial role in the extinction of aversive memories. As the amygdala is presumably involved in this process, we investigated the effects of the cannabinoid receptor agonist WIN 55,212-2 (WIN-2) on synaptic transmission in the lateral amygdala (LA) of wild-type and cannabinoid receptor type 1 (CB1)-deficient mice. Extracellular field potential recordings and patch-clamp experiments were performed in an in vitro slice preparation. We found that WIN-2 reduces basal synaptic transmission and pharmacologically isolated AMPA receptor- and GABA_A receptor-mediated postsynaptic currents in wild-type, but not in CB1-deficient mice. These results indicate that, in the LA, cannabinoids modulate both excitatory and inhibitory synaptic transmission via CB1. WIN-2-induced changes of paired-pulse ratio and of spontaneous and miniature postsynaptic currents suggest a presynaptic site of action. Inhibition of G_i/o proteins and blockade of voltage-dependent and G protein-gated inwardly rectifying K⁺ channels inhibited WIN-2 action on basal synaptic transmission. In contrast, modulation of the adenylyl cyclase-protein kinase A pathway, and blockade of presynaptic N- and P/Q- or of postsynaptic L- and R/T-type voltage-gated Ca²⁺ channels did not affect WIN-2 effects. Our results indicate that the mechanisms underlying cannabinoid action in the LA partly resemble those observed in the nucleus accumbens and differ from those described for the hippocampus.     

From ‘Is’ to ‘Ought’ in Moral Epistemology

Many philosophers claim that no formally valid argument can have purely non-normative premises and a normative or moral conclusion that occurs essentially. Mark Nelson recently proposed a new counterexample to this Humean doctrine:All of Dahlia's beliefs are true.Dahlia believes that Bertie morally ought to marry Madeleine. Bertie morally ought to marry Madeleine.I argue that Nelson's universal premise has no normative content, that Nelson's argument is valid formally, and that Nelson's moral conclusion occurs essentially and not vacuously. Nonetheless, I show that Nelson's argument faces a more fundamental problem if it is used in moral epistemology. An argument that appeals to a moral authority, such as Dahlia, might justify some moral belief out of a contrast class that does not include extreme views like moral nihilism; but it begs the question against moral nihilism, since one cannot be adequately justified in believing the conjunction of its premises without depending on assumptions that moral nihilists would deny. Thus, arguments like Nelson's can accomplish something important in moral epistemology, but their use is strictly limited.     

Pastoral counseling for self-transcendence: The integration of psychology and theology

Conclusion In the concept of self-transcendence pastoral counseling can integrate psychology and theology by seeing them as two complementary interpretations of the single radical drive of the human spirit. By moving beyond ourselves in creative understanding, realistic judgment, responsible decision, and generous love we both realize our authentic being (true self) and respond to the gospel's call to loving service of the neighbor. A psychology that understands self-realization as self-transcendence and a theology that recognizes the gospel as a call to self-transcendence require no connecting bridge or reconciliation, only the discovery of their intrinsic unity as interpretations of the same fundamental human drive for self-transcendence.     

You Can't Lose What you Ain't Never Had: A Reply to Marquis on Abortion

Philosophical Studies -     

The Representation of Knowledge in Minds and Machines

Human knowledge can be represented as a propositional network in which the meaning of a node is defined by its position in the network. That is, the relationship between a node and its neighbours determines how this node is used in language understanding and production, i.e., its meaning. The propositions that make up such a network are predicate-argument structures with time and location slots. Schemas, frames, and production rules can be expressed in the same formalism. Implications for this contextual view of meaning are discussed. Since the construction of such a propositional network depends on hand coding and is therefore impractical, an alternative automatic statistical procedure is explored that yields a high-dimensional semantic space. Vectors in this space correspond to nodes in the propositional network, in that the meaning of a vector in the Latent Semantic Analysis space is given by its neighbouring vectors in that space.