Conceptual organization and memory in nonretarded, mildly retarded, and moderately retarded adults

Moderately retarded, mildly retarded, and nonretarded adults learned a list of 12 items from three categories to a criterion of 75% correct recall in a free-recall learning paradigm. Retention was measured 1 week later. The moderately retarded took more trials and had lower retention and clustering scores than the others. The mildly retarded took more trials and had lower retention than the nonretarded. The results violate Murdock's total time hypothesis (Cooper & Pantle, 1967) but support Mandler's (1967) contention that learning is enhanced by the mental capacity for organization.     

MOOD AND WELL-BEING IN CONSECUTIVE MENSTRUAL CYCLES Methodological and Theoretical Implications

The level of consistency of cyclical change in well-being between consecutive menstrual cycles has important methodological, clinical, and theoretical implications. In this study, 109 women completed daily diaries of mood and physical well-being for two consecutive menstrual cycles. Scores in equivalent cycle phases were highly correlated, but the degree and direction of change from the pre-post menstrual phase were less consistent between cycles. Physical experiences proved more consistent across cycles than did emotional ones. Only 5.4% (nonsteroidal contraceptive users) and 7.8% (oral contraceptive users) of Cycle 2 emotional score variance could be accounted for by Cycle 1 scores compared to 15% and 22%, respectively, for physical scores. The data indicate that premenstrual experiences vary between menstrual cycles, and suggest that they cannot be adequately explained on the basis of simple biological determinism. Methodological and theoretical implications of the results are discussed.     

Third Parties and the Social Scaffolding of Forgiveness

It is widely accepted that only the victim of a wrong can forgive that wrong. Several philosophers have recently defended “third‐party forgiveness,” the scenario in which A, who is not the victim of a wrong in any sense, forgives B for a wrong B did to C. Focusing on Glen Pettigrove's argument for third‐party forgiveness, I will defend the victim's unique standing to forgive, by appealing to the fact that in forgiving, victims must absorb severe and inescapable costs of distinctive kinds, a plight that third parties do not share. There are, nonetheless, significant, even essential, roles played by third parties in making forgiveness possible, reasonable, or valuable for victims of serious wrongs. I take a closer look at the links between victims, wrongdoers, resentment, and forgiveness in showing why the victim alone can forgive.     

Holy piracy: Kopimism,the sacralisation of information,and the legitimating power of religion

Kopimism is a new religious movement predicated on, and revolving around, the assertion and belief that information is inherently sacred and needs to be copied and shared. Adherents to this Swedish-born religious movement have persisted in small pockets of devout communities around the world for almost a decade. This paper outlines a rudimentary and general sketch of the Kopimist worldview, its basic aims and its place within the contemporary religious landscape. In the latter part of this analysis, particular attention is given to the movement’s claim that it is not simply a sacralisation of political ideals – pirate politics, in particular – but that it maintains a distinct worldview and ethical system based on the notion that information – the foundation of everything – is itself divine. ‘Religion’ as a legitimating categorical force and the sociocultural conditions that engender new religious movements are also considered alongside the movement’s history and development.     

Maternal separation in early life impairs tumor immunity in adulthood in the F344 rat

Neonatal stress alters the hypothalamic-pituitary-adrenal (HPA) axis in rodents, such that, when these animals are exposed to stress as adults they hypersecrete corticosterone. Given that glucocorticoids are immunosuppressive, we examined the impact of maternal separation on HPA axis reactivity, natural killer (NK) cytotoxicity, and tumor growth in Fischer 344 rats following chronic restraint stress in adulthood. Pups underwent a chronic stress protocol whereby they were separated from their dams for 3 h on postnatal days 1-21. In adulthood, corticosterone responses were assessed following exposure to chronic (6 days for 10 h) restraint stress. Rats allocated to the chronic stress condition were inoculated with MADB106 tumor cells on day 4 of the restraint protocol. Blood was assessed for NK cytotoxicity on the final day of the chronic restraint protocol, and tumor colonization was assessed 3 weeks thereafter. Maternal separation impaired developmental weight gain (P < 0.05), depressed NK cytotoxicity (P < 0.05), and increased tumor colonization in the presence of chronic restraint stress in adulthood (P < 0.00 l). These findings occurred independently of circulating plasma corticosterone as only adult stress exposure potentiated corticosterone responses (P < 0.05). Our findings indicate that maternal separation and chronic stress can impair NK cytotoxicity and hence tumor immunity, but these effects are not directly mediated by perturbations in HPA axis function.     

Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems

Repeated cycles of ethanol intoxication and withdrawal associated with dependence induce neuroadaptations in a variety of brain systems. Withdrawal-induced negative emotional states can be ameliorated by ethanol consumption; a learned process termed negative reinforcement. Accordingly, a dependence-induced phenotype is escalated ethanol self-administration. Matrix metalloproteinases (MMPs) are proteolytic enzymes which degrade the extracellular matrix to allow for synaptic reorganization and plasticity. To test the hypothesis that an intact MMP system is required for animals to learn about the negative reinforcing effects of ethanol and display escalated self-administration during acute withdrawal when ethanol-dependent, male Wistar rats were trained to self-administer ethanol and then assigned to either acute or chronic MMP inhibition treatment groups. The chronic treatment group received intracerebroventricular (ICV) infusions of the broad spectrum MMP inhibitor FN-439 or artificial cerebrospinal fluid (aCSF) via osmotic minipumps during a 1 month ethanol dependence induction period and subsequent post-dependence induction self-administration sessions that occurred during acute withdrawal. The acute treatment group only received ICV FN-439 or aCSF on the day of self-administration sessions following dependence induction during acute withdrawal. The results showed that inhibition of MMPs attenuated escalated ethanol self-administration following chronic and acute exposure conditions. Furthermore, once learning (i.e., plasticity) had occurred, MMP inhibition had no impact on escalated response patterns and animals previously subjected to MMP inhibition that did not escalate evidenced normal escalations in operant ethanol self-administration once FN-439 treatments were terminated. Thus, the present data identified that an intact MMP system is required for the escalated responding that occurs during acute withdrawal in dependent animals and implicate such escalation as a learned response.