Recommendations from Multi-disciplinary Focus Groups on Cascade Testing and Genetic Counseling for Fragile X-associated Disorders

The purpose of this paper is to report the outcome of a collaborative project between the Fragile X Research and Treatment Center at the Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute at the University of California at Davis, the National Fragile X Foundation (NFXF), and the Centers for Disease Control and Prevention (CDC). The objective of this collaboration was to develop and disseminate protocols for genetic counseling and cascade testing for the multiple disorders associated with the fragile X mental retardation 1 (FMR1) mutation. Over the last several years, there has been increasing insight into the phenotypic range associated with both the premutation and the full mutation of the FMR1 gene. To help develop recommendations related to screening for fragile X-associated disorders, four, two day advisory focus group meetings were conducted, each with a different theme. The four themes were: (1) fragile X-associated tremor/ataxia syndrome (FXTAS); (2) premature ovarian failure (POF) and reproductive endocrinology; (3) psychiatric, behavioral and psychological issues; and (4) population screening and related ethical issues.     

A longitudinal multilevel model analysis of the within-person and between-person effect of effortful engagement and academic self-efficacy on academic performance

Using data from an accelerated longitudinal study, we examined the within-person and between-person effect of effortful engagement and academic self-efficacy on academic performance across students (N = 135) in elementary school. Teachers assessed participants' effortful engagement and participants rated their academic self-efficacy once per year for 3 years. Academic performance was assessed through standardized test scores in reading and math. Multilevel models indicated that within-person change in Effortful Engagement and Academic Self-Efficacy scores significantly predicted concomitant within-person change in reading test scores, B = 2.71, p = .043, Pseudo-R² = .02 and B = 4.72, p = .005, Pseudo-R² = .04, respectively. Participants with higher between-person levels of Effortful Engagement had higher initial reading test scores, B = 10.03, p = .001, Pseudo-R² = .09, and math test scores, B = 11.20, p < .001, Pseudo-R² = .15, whereas participants with higher between-person levels of Academic Self-Efficacy showed a faster rate of increase in math test scores across elementary school, B = 10.21, p = .036, Pseudo-R² = .25. At the between-person level, Effortful Engagement mediated the association between Academic Self-Efficacy and both reading and math test scores, although no support was found for mediation at the within-person level. Collectively, results suggest that trait-level psychological factors can vary meaningfully within school-aged children and that both within-person change and between-person individual differences in these traits have important consequences for academic performance.     

Ideological Orientation and Political Transition in Hong Kong: Confidence in the Future

In the two-component model of ideological orientation, a person's ideological position is jointly influenced by attitudinal and affective components. The present study adopted this conceptual model to predict confidence in the future of Hong Kong. Questionnaire responses were collected from 395 adults (56.8% men and 43.2% women) in Hong Kong in April 1995, some 2 years before its transfer from British to Chinese control. The results show that the level of confidence in Hong Kong was related to both attitudinal and affective identification with Hong Kong and China. These findings suggest that the transfer of government may have brought to the surface a collision of the divergent political cultures of Hong Kong and mainland China, resulting in two antagonistic political orientations that predicted confidence in the future of Hong Kong.     

Validating a “spurning scale” for nurses in Hong Kong

Based on a model on spumed helpers’ reactions, a spurning scale for nurses was constructed with items to assess the extent to which practicing nurses experience recurrent rejection of their help by patients and colleagues. Three approaches were employed to examine the validity of the scale: the relationship of the spurning scores with job satisfaction and turnover scores; the relationships of the spurning scores with burnout scores; and the relationships of the spurning scores with scores indicative of stress arising from interactions with one's patients, colleagues, and supervisor. Practicing nurses in Hong Kong (N = 212) who were enrolled in a refresher program of studies responded to a questionnaire containing the variables of interest. The results offered promising evidence for the validity of the scale.     

Biases and Standard Errors of Standardized Regression Coefficients

The paper obtains consistent standard errors (SE) and biases of order O(1/n) for the sample standardized regression coefficients with both random and given predictors. Analytical results indicate that the formulas for SEs given in popular text books are consistent only when the population value of the regression coefficient is zero. The sample standardized regression coefficients are also biased in general, although it should not be a concern in practice when the sample size is not too small. Monte Carlo results imply that, for both standardized and unstandardized sample regression coefficients, SE estimates based on asymptotics tend to under-predict the empirical ones at smaller sample sizes.     

Predicting intergroup bias: the interactive effects of implicit theory and social identity

This research sought to integrate the implicit theory approach and the social identity approach to understanding biases in intergroup judgment. The authors hypothesized that a belief in fixed human character would be associated with negative bias and prejudice against a maligned group regardless of the perceiver's social identity. By contrast, a belief in malleable human character would allow the perceiver's social identity to guide intergroup perception, such that a common ingroup identity that includes the maligned group would be associated with less negative bias and prejudice against the maligned group than would an exclusive identity. To test these hypotheses, a correlational study was conducted in the context of the Hong Kong 1997 political transition to examine Hong Kong Chinese's perceptions of Chinese Mainlanders, and an experimental study was conducted in the United States to examine Asian Americans' perception of African Americans. Results from both studies supported the authors' predictions.     

A comparative study on the flow experience in web-based and text-based interaction environments

The purpose of this study was to explore a substantial phenomenon related to flow experiences (immersion) in text-based interaction systems. Most previous research emphasizes the effects of challenge/skill, focused attention, telepresence, web characteristics, and systems' interface design on users' flow experiences in online environments. However, text-based interaction systems without telepresence features and web characteristics still seem to create opportunities for flow experience. To explore this phenomenon, this study incorporates subject involvement and interpersonal interaction as critical antecedents into the model of flow experience, as well as considers the existence of telepresence. Results reveal that subject involvement, interpersonal interaction, and interactivity speed are critical to focused attention, which enhances users' immersion. With regard to the effect of telepresence, the perceived attractiveness of the interface is a significant facilitator determining users' immersion in web-based, rather than in text-based, interaction environments. Interactivity speed is unrelated to immersion in both web-based and text-based interaction environments. The influence of interpersonal involvement is diminished in web-based interaction environments. The implications and limitations of this study are discussed.     

Analysis of ordinal categorical data with misclassification

We develop a method for the analysis of multivariate ordinal categorical data with misclassification based on the latent normal variable approach. Misclassification arises if a subject has been classified into a category that does not truly reflect its actual state, and can occur with one or more variables. A basic framework is developed to enable the analysis of two types of data. The first corresponds to a single sample that is obtained from a fallible design that may lead to misclassified data. The other corresponds to data that is obtained by double sampling. Double sampling data consists of two parts: a sample that is obtained by classifying subjects using the fallible design only and a sample that is obtained by classifying subjects using both fallible and true designs, which is assumed to have no misclassification. A unified expectation–maximization approach is developed to find the maximum likelihood estimate of model parameters. Simulation studies and examples that are based on real data are used to demonstrate the applicability and practicability of the proposed methods.     

Influence analysis of ranking data

This paper develops diagnostic measures to identify those observations in Thurstonian models for ranking data which unduly influence parameter estimates that are obtained by the partition maximum likelihood approach of Chan and Bentler (1998). Diagnostic measures are constructed by employing the local influence approach that uses geometric techniques to assess the effect of small perturbations on a postulated statistical model. Very little additional effort is required to compute the proposed diagnostic measures, because all of the necessary building blocks are readily available after a usual fit of the model. The work described in this paper was partially supported by the grants from the Research Grants Council of the Hong Kong Special Administrative Region, China (RGC Ref. No. CUHK4186/98P and RGC Direct Grant ID2060178). The authors are grateful to the Editor and four anonymous referees for their helpful comments.