细胞周期相关因子cdt1和geminin的平衡

cdt1和geminin是重要的细胞周期相关因子,参与细胞周期的调控cdt1与某些疾病的发生有着密切的关系,geminin是cdt1的抑制因子,他们间的平衡对DNA复制;;基因稳定以及细胞周期的调控起着重要的作用,并已经在一些感染性疾病和肿瘤中证实     

实验室检验失血与医源性贫血——ICU的潜在危机

所有的住院患者均需采血进行实验室检测,而ICU中的危重患者则更为频繁.有很多原因促使医生开立检验单,以明确疾病的诊断和治疗,但由此而产生的失血却往往易被忽视.病情的危重程度和器官功能障碍程度是检验失血量的主要影响因素,但同时采血技术、检验分析仪性能以及医生开立检验单的目标和规范性等欠佳会增加血液标本的浪费.积极地进行规范的医疗管理和实验室仪器设备的改进等,在满足患者病情治疗需要的前提下尽量降低检验性失血,需要全社会的努力.     

民族本质论对民族认同和刻板印象的影响

The simple understanding of ethnicity by lay people is called the lay people’s theory of ethnicity, two theories are used to interpret the ethnicity by lay people in their everyday life. One of the theories contends that ethnicity is determined by nonmalleable, deep-seated essence and the essence would give rise to stable personality traits and abilities across situations, this is called the essentialist theory of ethnicity. The other theory, however, denies the real existence of ethnic essence, ethnicity is a social construction that is arbitrarily created due to social and political reasons in historical contexts, which is termed the social constructivist theory. Some western studies have shown that people have different interpretation about ethnicity cause different group perceptions and group relations. It is necessary to test and extend these results in another social background, like the Chinese one. First, 351 students from different ethnic groups participated in Study 1. They completed a questionnaire aimed at assessing their attitudes towards inter-group perception, ethnic identity, lay people’s theory of ethnicity, and out-group contact attitude. The results showed that: (1) the stronger essentialist belief a participant has, the more sensitive he or she is about group difference; (2) essentialist theory affects people’s inter-group identity, i.e. the deeper one believes in essentialism, the tenser he or she feels about in-group identity and bias, the more passive attitude is hold towards out-group contact. Second, 104 Han students participated in Study 2. An experimental method was used to test stereotyping differences against the minorities in relationship to lay people’s ethnic theories. Participants were randomly assigned to read the article advocating the essentialist view of ethnicity or the article advocating the social constructionist view of ethnicity. The result illustrates that: participants in the essentialist ethnicity condition showed stronger stereotyped impressions, especially negative stereotyping than did those in the social constructionist condition, but participants in the two conditions did not differ significantly on their positive stereotyping. In conclusion, the essentialist theory of ethnicity has a great influence on ethnic identity and ethnic stereotyping. Practical implications of these results imply that lay people’s theory of ethnicity can be used as a vehicle for reducing prejudice. Specifically, we can teach people to hold more social constructivist belief and less essentialist belief.     

对“全健康”与社会−自然关系演变的思考

随着新冠疫情暴发,多年来公共卫生事件频繁出现暴露出如今社会−自然关系在认知、文化和行为方面存在多种矛盾,人类社会与自然的关系不得不再次引起审视。全健康理念的出现呼吁人们通过重视全生命健康、促进全地域合作、协调全方位贯通使人类与动物、环境达成共同公平健康,该理念在当下公共卫生安全紧张的时期为社会−自然关系演变指明了方向。我国需要树立正确生态认知、加强国际协作、践行全健康理念,才可以与生态环境和谐共处,我们同处一个世界只享有同一种健康,即全健康。

     

基于广义科学哲学的中医本性新解读

在充分研究国内外相关文献的基础上,阐述了中医本性问题的研究背景,对现有的研究成果进行了评价,并提出了未来的研究思路,系统地利用广义科学哲学的丰富理论资源从理论、实践和文化三个视角深入探讨了中医的科学性问题,较为全面地研究了中医的本性.     

医学技术一级学科建设基础理论研究

医学技术是我国医学门类下的新兴一级学科,通过分析医学技术一级学科的发展历程、学科内涵、研究对象、学科性质、学科体系、学科建设的意义和作用等方面,指出该学科发展建设过程中仍存在理论体系尚待丰富、分支学科尚需分化、高端人才缺乏、多层次人才培养和学位体系需要构建等问题。     

ICU患者的浅镇静：我们追求的目标？

镇静治疗是ICU综合治疗的重要组成部分。随着ICU的发展,先后颁布了3个有关ICU患者的镇静指南,镇静治疗的理念也逐渐发生改变。2013年美国重症医学会颁布的ICU成人患者疼痛、躁动、谵妄治疗指南推荐的镇静目标为浅镇静。该指南是以大量临床研究结论为基础提出的,更具有广泛代表性和推广价值。本文从浅镇静的理论基础、具体实施方案、镇静深度的监测、镇静药物的选择以及浅镇静的局限性等方面具体阐述ICU患者浅镇静策略的相关问题,以期ICU同道能更好地理解和临床实施ICU成人患者的浅镇静策略。     

发热伴阵发性呼吸困难——感染继发肺栓塞4例临床治疗观察并文献复习

为总结感染继发肺栓塞的临床特点和处理,回顾性分析4例感染继发肺栓塞患者的诊治经过.结果 4例患者在强力有效抗感染治疗基础上溶栓并序贯抗凝治疗后均获得康复.提示有明确肺梗塞病灶及明显低氧血症存在的感染继发肺栓塞患者,在充分抗感染治疗基础上进行抗凝治疗的同时,必要时可以慎重溶栓治疗.     

维生素D3及其受体的临床意义

1,25-(OH)2D3是维生素D在体内发挥生理作用的活性形式.活性维生素D3通过与细胞内特异性维生素D受体结合,除了具有调节钙磷代谢的功能外,还发现其可预防和治疗骨质疏松、心血管疾病、自身免疫性疾病和一些肿瘤等.然而,维生素D缺乏在人群中非常普遍.     

重症感染非抗感染措施的思考

近年来严重感染与感染性休克治疗策略的主要进展是对强化血糖控制、糖皮质激素等疗法的再评价.同时,也出现了诸如血管加压素、他汀类药物、选择性口腔/肠道脱污染等新的治疗措施,并取得了一定成果.本文对相关研究进展进行综述,以阐明集束化策略和管理水平的提高可能是最终降低重症感染病死率的关键.