Mice with targeted genetic reduction of GABA(A) receptor alpha1 subunits display performance differences in Morris water maze tasks

Recent research has begun to demonstrate that specific subunits of GABA(A) receptors may be involved in the normal expression of specific behaviors. The present research used mice with GABA(A) receptors whose alpha1 subunits contained mutations of serine 270 to histidine and leucine 277 to alanine in the TM2 region. The purpose was an attempt to examine the possible role that this particular subunit may have in learning the spatial and nonspatial version of the Morris water maze task. Mutant animals, compared to controls, displayed elevated levels of pool circling in both the spatial task and the nonspatial task. These results suggested that normal performance of the spatial and nonspatial water maze tasks may be dependent upon a natural alpha1 subunit array.     

Comprehensive soldier fitness: building resilience in a challenging institutional context

The Comprehensive Soldier Fitness (CSF) program is designed to increase psychological strength and positive performance and to reduce the incidence of maladaptive responses of the entire U.S. Army. Based on the principles of positive psychology, CSF is a historically unique approach to behavioral health in a large (1.1 million members) organization. There are four program elements: (a) the assessment of emotional, social, family, and spiritual fitness; (b) individualized learning modules to improve fitness in these domains; (c) formal resilience training; and (d) training of Army master resilience trainers (MRTs) to instill better thinking skills and resilience in their subordinates. In contrast to traditional approaches, CSF is proactive; rather than waiting to see who has a negative outcome following stress, it provides ways of improving resilience for all members of the Army. CSF aims to move the full spectrum of responses to trauma and adversity-ranging from stress-related disorders to ordinary resilience-toward personal growth. This program may provide a model for implementing similar interventions in other very large institutions.     

Task-induced fatigue states and simulated driving performance

States of fatigue are implicated in driver impairment and motor vehicle accidents. This article reports two studies investigating two possible mechanisms for performance impairment: (1) loss of attentional resources; and (2) active regulation of matching effort to task demands. The first hypothesis predicts that fatigue effects will be accentuated by high task demands, but the second hypothesis predicts that fatigue effects will be strongest in "underload" conditions. In two studies, drivers performed a stimulated driving task, in which task demands were manipulated by varying road curvature. In a "fatigue induction" condition, the early part of the drive was occupied by performance of a demanding secondary task concurrently with driving, after which the concurrent task ceased. Post-induction driving performance was compared with a control condition in which drivers were not exposed to the induction. In both studies, the fatigue induction elicited various subjective fatigue and stress symptoms, and also raised reported workload. Fatigue effects on vehicle control and signal detection were assessed during and after the fatigue induction. The fatigue induction increased heading error, reduced steering activity, and, in the second study, reduced perceptual sensitivity on a secondary detection task. These effects were confined to driving on straight rather than on curved road sections, consistent with the effort regulation hypothesis. The second study showed that fatigue effects were moderated by a motivational manipulation. Results are interpreted within a control model, such that task-induced fatigue may reduce awareness of performance impairment, rather than reluctance or inability to mobilize compensatory effort following detection of impairment.     

Incorporating a Psychological Counselor in a Cancer Risk Assessment Program: Necessity, Acceptability, and Potential Roles

Evidence suggests that cancer risk assessment may be associated with increased psychological distress. This exploratory study assessed the necessity and acceptability of incorporating psychological counseling into routine clinic procedures at a cancer risk program. Following a visit to a university-based cancer risk clinic, patients (N = 102) completed an anonymous self-report instrument. Participants reported experiencing current stress and anxiety (41%), depression (29%), and suicidal ideation (2%). Patients with a history of cancer were more likely to be experiencing current emotional difficulties. Sixty-nine percent of the participants found the visit with the psychological counselor to be helpful, while 41% of the participants reported interest in follow-up psychological services. Interest in receiving future psychological services was positively correlated with levels of anxiety, depression, and cancer worry. This pilot study demonstrates the acceptability and potential role for psychological counselors in increasing adjustment in high-risk patients undergoing genetic counseling for inherited cancers.     

Yoked variable-ratio and variable-interval responding in pigeons

Pigeons' key pecks were maintained by variable-ratio or variable-interval schedules of food reinforcement. For pairs of pigeons in one group, variable-ratio reinforcement was arranged for one pigeon's pecks; for the second pigeon, reinforcement was arranged according to a variable-interval schedule yoked to the interreinforcement times produced by the first pigeon. For pairs of pigeons in another group, variable-interval reinforcement was arranged for one pigeon's pecks; for the second pigeon, reinforcement was arranged according to a variable-ratio schedule yoked to the interreinforcement responses produced by the first pigeon. For each pair, the yoking procedure was maintained for four or five consecutive sessions of 50 reinforcements each. In more than three-quarters of the pairs, variable-ratio response rates were higher than variable-interval rates within two sessions; in all cases, the rate difference developed within four sessions.     

Association and categorisation effects on free recall

Lists of 18 words which varied in mean associative strength, the category membership of the associations and in word frequency were presented to subjects 3 times with recall required after each presentation. Recall efficiency increased with association level and with similarly categorised associates. In lists of High mean associative strength which consisted of similarly categorised words, the recall of high frequency word lists was facilitated but at low levels of associative strength, with similarly categorised words, recall was facilitated at both levels of word frequency used. Clustering and errors which were associatively related to the items being learned were greater in lists which contained sets of similarly categorised associates.     

Influence of age, sex, and family on Type A and hostile attitudes and behaviors.

We describe the influence of age, sex, and family on Type A and hostility indices that have been related to rates of coronary heart disease (CHD). The sample consisted of 120 girls and 95 boys (ages 6 to 18 years) and 141 women and 120 men (ages 31 to 62 years) from 142 families residing in an upper middle class community. Results showed little familial aggregation of Type A and hostility. Adults had higher Structured Interview (SI) Potential for Hostility ratings than did children, whereas children had higher Minnesota Multiphasic Personality Inventory (MMPI)-derived Hostility scores and SI Anger-In ratings than did adults. Male adults and male children had higher SI Potential for Hostility ratings and MMPI-derived Hostility scores than did their female counterparts. The heightened hostility of males may account, in part, for their heightened risk of CHD relative to females'.