Accelerated development of cardiac sympathetic responses in spontaneously hypertensive (SHR) rats

The functional development of cardiac and adrenal medullary responses to reflex activation of the sympathetic nervous system was studied in preweanling spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) normotensive rats. Pups of the two strains received injections of insulin or saline at 2, 4, 8, 12, or 16 days of age and were sacrificed 3 h later. Insulin administration produces a significant decrease in circulating levels of glucose which in turn results in a centrally mediated increase in sympathetic outflow. The induction of ornithine decarboxylase (ODC) in heart and the depletion of epinephrine from the adrenal medulla served as tissue markers of functional sympathetic neurotransmission. WKY and SHR pups had comparable levels of ODC activity in heart under basal conditions. In contrast, levels of catecholamines in the adrenals were greater in SHR pups at 2 and 4 days of age. Following insulin administration, SHR pups exhibited a greater induction of cardiac ODC activity at 2, 4, and 8 days of age compared to age-matched WKY controls. However, there were no differences between SHR and WKY pups in the magnitude of the adrenal medullary response to insulin-induced hypoglycemia. These alterations in sympathetic-target tissue development during the first postnatal week of life may contribute in part to the higher arterial pressures maintained by SHRs throughout the lifespan.     

Anisomycin impairs long-term working memory in a delayed alternation task

A long-term temporal component of working memory of rats trained on the radial maze has been shown to be susceptible to disruption by the protein synthesis inhibitor, anisomycin. It is not clear whether protein synthesis played a role in working memory because accurate performance on the radial maze required the storage of a large amount of information, or because the information was to be held in store for relatively long periods of time. This experiment tested these hypotheses by assessing the effect of anisomycin on choice accuracy in a comparatively simple spatial delayed alternation task. Results indicate that under the present training conditions, protein involvement in working memory is related more to the length of the retention interval than to the amount of information retained.     

Modulation of male mouse sniff, attack, and mount behaviors by estrous cycle-dependent urinary cues

Modulation of male urogenital sniff, attack, and mount behaviors by urinary cues from female mice (SJL/J) was assessed in two experiments. Experiment 1 examined the efficacy of urine from ovariectomized and intact females in modulating the behavior of sexually experienced and inexperienced males vis-à-vis the control substance, water. It was found that urine from ovariectomized females showed no behavior-modulating properties, whereas urine from intact females decreased attack but increased sniff and mount behaviors in male mice. These findings are indicative of ovarian-dependent chemosignals contained in the urine of only intact females. Prior sexual experience had no effect on behavior of males when exposed to urine from ovariectomized females. Sniff and mount behaviors were, however, increased when sexually experienced males were exposed to urine from intact females. Using sexually inexperienced males, Experiment 2 assessed the chemosignal activity of urine from females in each of four estrous phases. It was determined that urine from proestrous and estrous females increased sniff and mount behaviors and decreased attack behavior. Urine from metaestrous females was shown to possess only sniff-inducing and mount-reducing chemosignal properties. Urine from females in diestrous lacked attack- and mount-modulating chemocues but may possess a sniff-inducing chemosignal.     

Structure and process in semantic memory: new evidence based on speed-accuracy decomposition

Reaction-time and accuracy data obtained from studies of sentence verification have not been rich enough to answer certain important theoretical questions about structures and processes in human semantic memory. However, a new technique called speed-accuracy decomposition (Meyer, Irwin, Osman, & Kounios, 1986) may help solve this problem. The technique allows intermediate products of sentence verification to be analyzed more precisely. Three experiments with speed-accuracy decomposition indicate that verification processes produce useful partial information before they are completed. Such information appears to accumulate continuously at a rate whose magnitude depends on the degree of relatedness between semantic categories. This outcome is consistent with continuous computational (e.g., semantic-feature comparison) models of semantic memory. An analysis of reaction-time minima suggests that a discrete all-or-none search process may also contribute at least occasionally to sentence verification. Further details regarding the nature of these processes and the memory structures on which they operate can be inferred from additional results obtained through speed-accuracy decomposition.     

Time horizons in rats foraging for food in temporally separated patches

An important tenet of optimal foraging theory is that foragers compare prey densities in alternative patches to determine an optimal distribution of foraging behavior over time. A critical question is over what time period (time horizon) this integration of information and behavior occurs. Recent research has indicated that rats do not compare food density in a depleting patch with that in a rich patch delayed by an hour or more (Timberlake, 1984). In the present research we attempted to specify over what time period a future rich patch would affect current foraging. The effect of future food was measured by early entry into the rich patch (anticipation) and by a decrease in food obtained in the depleting patch (suppression). The rats showed anticipation of a rich patch up to an hour distant, but suppressed current feeding only if the rich patch was 16 min distant or less. The suppression effect appeared mediated by competition for expression between anticipatory entries into the rich patch and continued foraging in the depleting patch. These results suggest that optimal foraging is based on a variety of specific mechanisms rather than a general optimizing algorithm with a single time horizon.     

Pavlovian analysis of interactions between hunger and thirst

In four experiments we examined the effect of an irrelevant drive on classical conditioning with food and water. In the first experiment the irrelevant drive weakened the conditioned response in extinction. In Experiments 2 and 3, this suppressive effect was found also in acquisition. Furthermore, the presence of an irrelevant drive during nonreinforced presentations of the conditioned stimulus was found to protect the conditioned response from extinction. Experiment 4 showed that the depressive effect of the irrelevant drive is manifested only when the relevant drive is present. Taken together, these results suggest that an irrelevant drive can influence conditioned responding by modulating the representation of the unconditioned stimulus.     

Effects of foveal priming and extrafoveal preview on object identification

The results of three different experiments suggested that the relation between an object in the fovea on fixation n and an object subsequently brought into the fovea on fixation n + 1 affects the time to identify the second object. In Experiment 1 we extended previous work by demonstrating that a previously seen related priming object speeded the time to name a target object even when a saccade intervened between the two objects. In Experiment 2 we replicated this result and further showed that the benefit on naming time was due to facilitation from the related object rather than inhibition from the unrelated object. In addition, naming of the target object was much slower in both experiments when there was not a peripheral preview of the target object on fixation n. However, because the effect of the foveal priming object was greater when the target was not present than when it was present, priming did not appear to make extraction of the extrafoveal information more efficient. In Experiment 3, fixation times were recorded while subjects looked at four objects in order to identify them. Fixation time on an object was shorter when a related object was fixated immediately before it, even though the four objects did not form a scene. The size of the facilitation was roughly comparable to that in several analogous experiments where scenes were used. The results suggest that the effects of a predictive scene context on object identification may be explainable in terms of an object-to-object or "intralevel" priming mechanism.     

Perceptual normalization of vowels produced by sinusoidal voices

When listeners hear a sinusoidal replica of a sentence, they perceive linguistic properties despite the absence of short-time acoustic components typical of vocal signals. Is this accomplished by a postperceptual strategy that accommodates the anomalous acoustic pattern ad hoc, or is a sinusoidal sentence understood by the ordinary means of speech perception? If listeners treat sinusoidal signals as speech signals however unlike speech they may be, then perception should exhibit the commonplace sensitivity to the dimensions of the originating vocal tract. The present study, employing sinusoidal signals, raised this issue by testing the identification of target /bVt/, or b-vowel-t, syllables occurring in sentences that differed in the range of frequency variation of their component tones. Vowel quality of target syllables was influenced by this acoustic correlate of vocal-tract scale, implying that the perception of these nonvocal signals includes a process of vocal-tract scale, implying that the perception of these nonvocal signals includes a process of vocal-tract normalization. Converging evidence suggests that the perception of sinusoidal vowels depends on the relation among component tones and not on the phonetic likeness of each tone in isolation. The findings support the general claim that sinusoidal replicas of natural speech signals are perceptible phonetically because they preserve time-varying information present in natural signals.     

Observed behaviors during clinical interviews predict improvement in depression

A considerable percentage of depressed patients do not respond to antidepressive treatment. Early indicators of prognosis are needed. The aims of this study are to examine (a) whether the interpersonal behavior of patients and psychiatrist, as assessed by means of direct observation of behavior during a baseline clinical interview, might have predictive value with respect to therapeutic outcome and (b) which predictive potency measures of psychomotor activation, as assessed by less refined methods, such as global clinical judgment, might have. In the analysis used, speech-pause behavior was taken as the basic structure of the interaction. The relations of other behaviors such as looking and hand and head movement with this structure were determined. Evidence is presented that in a group of 31 depressives, improvement after a period of 10 weeks was related to observed behaviors during a baseline interview. The behaviors of the patients are interpreted as relational or nonrelational. The relational behaviors (i.e., looking yesnodding, gesturing) occur less in patients who will improve, whereas the nonrelational behaviors (i.e., intensive body touching, head movements) occur more in these patients. The nonrelational behaviors are presumed to be indicative of the state of arousal. The predictive potency of these variables could not be explained by their relationship with the baseline severity of depression, which in itself also predicted improvement. Moreover, global clinical assessment of psychomotor activation (i.e., retardation and agitation) could not be related to outcome.     

Albert Ellis' personal responses to the Survey of Rational-Emotive Therapists

This article presents Albert Ellis' personal responses to the Survey of Rational-Emotive Therapists and his answers to a number of questions that the first and second authors asked Ellis regarding some of his responses. Ellis also commented on how adequately he thought the results of the survey appeared to represent the current philosophies and practices of RET.