Possibilities and initial results of the determination of reaction time in routine EEG recordings

The simple reaction timing method permits simultaneous observation of bioelectric factors affecting the times during synchronous EEG recording. The attention functions were checked during paroxysmal peak potential activity by measuring the reaction time. In only a few patients was there no change in the reaction time observed during paroxysmal peak activity. The first results, which are presented here, give rise to many questions in respect of diagnosis, therapy and medical opinion.     

Observational couple assessment: a cross-model comparison

This study compared the clinical rating scales from the Circumplex Model (CCRS), the McMaster Model of Family Functioning (MCRS) and the Family Health Scales (FHS). A central purpose was to investigate whether observational rating scales designed to measure family functioning can also be used to assess couple functioning. One hundred and sixty-six drug abusing women, receiving primary drug treatment in two metropolitan drug agencies in the southwest of the US, and their partners were videotaped while engaged in three couple tasks prior to receiving any treatment. The main findings indicated that all three rating scales have: (1) sufficient interrater reliability; (2) good construct validity, as reflected in factor analyses; and (3) very good convergent validity. However, there was some concern about whether these scales are as discriminating when measuring couples as they are when assessing families.     

Need for Family Therapy Services for Middle-Class Families in India

This qualitative study explored the needs of Indian middle-class families for family therapy services. Four focus group interviews were conducted with middle-class parents in Madras, India. Participants were introduced to the concept and practice of family therapy and were encouraged to take a more active role in supporting the services they suggested. Participants identified problems faced by Madras middle class families and five different types of services that they were aware of. Three categories of need for family therapy were identified from the narratives of the participants. Several themes fit in each of the three categories. Implications for clinical application are discussed.     

Increases in language lateralization in normal children as observed using magnetoencephalography

Previous functional magnetic resonance imaging (fMRI) studies investigating hemispheric dominance for language have shown that hemispheric specialization increases with age. We employed magnetoencephalography (MEG) to investigate these effects as a function of normal development. In sum, 22 healthy children aged 7-16 years were investigated using two language tasks: a verb-generation (VG) task and a vowel-identification (VI) task. Significant hemispheric differences were found for both tasks in cerebral language areas using oscillatory MEG spectral analyses, confirming the MEG's ability to detect hemispheric specialization for language in children. Additionally, a significant increase of this lateralization as a function of age was observed for both tasks. As performance in the VI task showed no correlation with age, this increase seems to be unrelated to performance. These results confirm an increase in hemispheric specialization as a function of normal brain maturation.     

Combined reasoning by automated cooperation

Different reasoning systems have different strengths and weaknesses, and often it is useful to combine these systems to gain as much as possible from their strengths and retain as little as possible from their weaknesses. Of particular interest is the integration of first-order and higher-order techniques. First-order reasoning systems, on the one hand, have reached considerable strength in some niches, but in many areas of mathematics they still cannot reliably solve relatively simple problems, for example, when reasoning about sets, relations, or functions. Higher-order reasoning systems, on the other hand, can solve problems of this kind automatically. But the complexity inherent in their calculi prevents them from solving a whole range of problems. However, while many problems cannot be solved by any one system alone, they can be solved by a combination of these systems.We present a general agent-based methodology for integrating different reasoning systems. It provides a generic integration framework which facilitates the cooperation between diverse reasoners, but can also be refined to enable more efficient, specialist integrations. We empirically evaluate its usefulness, effectiveness and efficiency by case studies involving the integration of first-order and higher-order automated theorem provers, computer algebra systems, and model generators.     

Hormonal and monoamine signaling during reinforcement of hippocampal long-term potentiation and memory retrieval

Recently it was shown that holeboard training can reinforce, i.e., transform early-LTP into late-LTP in the dentate gyrus during the initial formation of a long-term spatial reference memory in rats. The consolidation of LTP as well as of the reference memory was dependent on protein synthesis. We have now investigated the transmitter systems involved in this reinforcement and found that LTP-consolidation and memory retrieval were dependent on β-adrenergic, dopaminergic, and mineralocorticoid receptor (MR) activation, whereas glucocorticoid receptors (GRs) were not involved. Blockade of the β-adrenergic signaling pathway significantly increased the number of reference memory errors compared with MR and dopamine receptor inhibition. In addition, β-adrenergic blockade impaired the working memory. Therefore, we suggest that β-adrenergic receptor activation is the main signaling system required for the retrieval of spatial memory. In addition, other modulatory interactions such as dopaminergic as well as MR systems are involved. This result points to specific roles of different modulatory systems during the retrieval of specific components of spatial memory. The data provide evidence for similar integrative interactions between different signaling systems during cellular memory processes.     

Traumatische Trauer – ein eigenständiges Krankheitsbild?

Grief is a highly individualized process influenced by intrapsychic, interpersonal and social factors. The definition of normal and pathological grief is complicated by the variety of grief reactions. Empirical research indicates that pathological grief may be concerned considered as a separate entity. Two research groups developed empirically validated criteria with a special focus on the traumatic aspect of grief. The current state of research allows, however, in our opinion not the conclusion, that the proposed diagnostic criteria for complicated (Horowitz et al. 1997) or traumatic grief (Prigerson et al. 1999b) do not enclose all types of grief. Further empirical research on representative samples is necessary to validate previous findings and to differentiate specific subgroups of pathological grief.