Effects of pointing direction and direction predictability on event-related lateralizations of the EEG

In two experiments, we investigated hemispheric electroencephalography (EEG) differences in 9(12) healthy volunteers during pointing to lateral and central targets. The questions addressed were whether horizontal pointing direction and the predictability of pointing direction modulated hemispheric differences (event-related lateralizations of the EEG = ERLs). To vary pointing direction predictability, targets were displayed either randomly at one of nine different positions on a screen (random) or at the same horizontal position in five subsequent trials (sequenced) while vertical positions varied randomly. Event-related lateralizations (ERLs) varied with pointing direction. This was true across changes in target eccentricity and pointing distance. Foci of the ERLs were in premotor and posterior parietal cortex, which might reflect the critical involvement of these areas in the control of visually guided reaching. Direction predictability reduced the parietal and premotor ERL before pointing onset, probably reflecting a lesser effort in visuomotor transformation. Predictability also added an overlying N2pc component to the early ERL after target onset and increased direction effects during movement.     

Cortical plasticity associated with stuttering therapy

Neuroimaging studies have indicated that persistent developmental stuttering (PDS) may be associated both with an abnormality in white matter of left-hemispheric speech areas and a right-hemispheric hyperactivity. The latter may compensate for the deficient structural connectivity in the left hemisphere. To investigate the effects of stuttering therapy on brain activity nine male adults with PDS underwent functional magnetic resonance imaging (fMRI) before and within 12 weeks after fluency shaping therapy. Brain response differences during overt sentence reading before and after therapy were assessed by utilizing random effects analyses. After therapy, a more widespread activation was observed in frontal speech and language regions and temporal areas of both hemispheres, particularly and more pronounced on the left side. Interestingly, distinct posttreatment left-sided activation increases were located directly adjacent to a recently detected area of white matter anomaly [M. Sommer, M.A. Koch, W. Paulus, C. Weiller, C. Buchel (2002). Disconnection of speech-relevant brain areas in persistent developmental stuttering. The Lancet, 360, 380-383] suggesting that fluency shaping techniques reorganize neuronal communication between left-sided speech motor planning, motor execution, and temporal areas. Hence, a therapeutic mechanism can be assumed to remodel brain circuitry close to the source of the dysfunction instead of reinforcing compensation via homologous contralateral brain networks. EDUCATIONAL OBJECTIVES: The reader will learn about and be able to: (1) describe brain activation changes detected shortly after fluency-shaping therapy; (2) identify left-hemispheric regions where a (re)functionalization after fluency-shaping therapy seems to occur adjacent to a recently described abnormal white matter region in PDS subjects; and (3) discuss how an effective cerebral compensation mechanism for stuttering could work.     

Possible-Worlds Semantics for Modal Notions Conceived as Predicates

If is conceived as an operator, i.e., an expression that gives applied to a formula another formula, the expressive power of the language is severely restricted when compared to a language where is conceived as a predicate, i.e., an expression that yields a formula if it is applied to a term. This consideration favours the predicate approach. The predicate view, however, is threatened mainly by two problems: Some obvious predicate systems are inconsistent, and possible-worlds semantics for predicates of sentences has not been developed very far. By introducing possible-worlds semantics for the language of arithmetic plus the unary predicate , we tackle both problems. Given a frame <W,R> consisting of a set W of worlds and a binary relation R on W, we investigate whether we can interpret at every world in such a way that A holds at a world wW if and only if A holds at every world vW such that wRv. The arithmetical vocabulary is interpreted by the standard model at every world. Several paradoxes (like Montague's Theorem, Gödel's Second Incompleteness Theorem, McGee's Theorem on the -inconsistency of certain truth theories, etc.) show that many frames, e.g., reflexive frames, do not allow for such an interpretation. We present sufficient and necessary conditions for the existence of a suitable interpretation of at any world. Sound and complete semi-formal systems, corresponding to the modal systems K and K4, for the class of all possible-worlds models for predicates and all transitive possible-worlds models are presented. We apply our account also to nonstandard models of arithmetic and other languages than the language of arithmetic.     

The role of motion direction selective extrastriate regions in reading: a transcranial magnetic stimulation study

Why reading ability is correlated with motion processing ability is perplexing. Activity in motion direction processing regions (Area V5/MT+) was perturbed by means of repetitive transcranial magnetic stimulation (rTMS) to examine its effect on reading. A functional probe (significant shortening of the motion aftereffect) was used to identify Area V5/MT+. Right-handed participants (8 m, 8 f) received three 7.5 min blocks of rTMS, after which two phonological and one orthographic reading tasks were administered. Application of rTMS to Area V5/MT+ (as compared to a non-rTMS baseline) significantly decreased performance only during non-word naming. The pattern of naming errors and the absence of deficits on the second phonological task were not consistent with a role for Area V5/MT+ in phonological decoding. Instead, its role in reading may be limited to image stabilization and/or letter localization.     

Possession as role-taking

The paper discusses the psychological function of mythical roles in the genesis and maintenance of the possessional experience. The Devil as a personification of the evil provides a role which is possible to recognize and even interiorize. Theemotional psychological dynamics interacts with thecognitive content provided by the religious world-view. A case is analyzed and related to prior scientific studies in the field bordering psychopathology and pastoral experience.     

The value of confession and forgiveness according to Jung

This article represents a broad survey of the views of C. G. Jung regarding confession and for giveness. Man, a naturally religious being, has a need to confess his wrong and to gain forgiveness of one sanctioned to absolve. The curative effect of confession has been known for centuries. Without confession, man remains in moral isolation. Priests, ministers, and rabbis, as well as psychotherapists, attest to the universality of this human phenomenon. Confession is located in that place where psychology and religion meet-guilt. Jung's views on confession bridge the chasm between psychology and religion.     

The usefulness of economic analyses for policy support in health care

In the Netherlands economic analysis of medical technologies is increasingly recognized and used as an instrument for policy-making on different policy-levels in health care. This is mainly due to the introduction of a specific kind of medical technology assessment research, the so-called “investigative medicine.” In this type of health-care research the consequences (medical and quality of life) and the costs of a certain medical technology are usually simultaneously evaluated. Two characteristics of investigative medicine are discussed in the paper: the principle that research grants in this field are assigned to grant holders at University Hospitals and that the evaluation is often executed by means of economic analyses such as costeffectiveness analysis. He was engaged in forecasting research, manpower research and is currently involved in evaluative economic research in the field of health care. At the moment his main research activities concentrate on (computer) support of organizational change.     

Sin,Evil and Job: Monotheism as a psychological and pastoral problem

The Book of Job, as interpreted by Jung and Capps, reveals that evil exists in creation and has its source in God. Evil is the inevitable result of God choosing to be subject to logical norms in order to avoid a chaotic world. However, according to religious tradition, the good in God outweighs the evil, which is why believers in God go to God for help even when God seems to inflict suffering upon them.This paper arose from the course Personal Sin and Social Evil taught by Donald Capps and Richard K. Fenn at Princeton Theological Seminary in 1992.