The nature and treatment of stuttering as revealed by fMRI A within- and between-group comparison

This article reviews some of our recent functional magnetic resonance imaging (fMRI) studies of stuttering. Using event-related fMRI experiments, we investigated brain activation during speech production. Results of three studies comparing persons who stutter (PWS) and persons who do not stutter (PWNS) are outlined. Their findings point to a region in the right frontal operculum (RFO) that was consistently implicated in stuttering. During overt reading and before fluency shaping therapy, PWS showed higher and more distributed neuronal activation than PWNS. Immediately after therapy differential activations were even more distributed and left sided. They extended to frontal, temporal, and parietal regions, anterior cingulate, insula, and putamen. These over-activations were slightly reduced and again more right sided two years after therapy. Left frontal deactivations remained stable over two years of observation, and therefore possibly indicate a dysfunction. After therapy, we noted higher activations in persons who stutter moderately than in those who stutter severely. These activations might reflect patterns of compensation. We discuss why these findings suggest that fluency-inducing techniques might synchronize a disturbed signal transmission between auditory, speech motor planning, and motor areas.

Educational objectives: The reader will learn about and be able to: (1) identify regions of brain activations and deactivations specific for PWS; (2) describe brain activation changes induced by fluency shaping therapy; and (3) discuss the correlation between stuttering severity and brain activation.     

Author index 115 2003

Authors Index

Author index 115 2003     

The Werther effect and assisted suicide

In the course of a large epidemiological study in the region of Basle, Switzerland, from 1992 to 1996, a considerable rise in suicides assisted by the right-to-die society EXIT was uncovered after wide press coverage of an assisted double suicide of a prominent couple in that region in March 1995. Further investigation revealed that the rise of assisted suicides for a period of 2 years after the critical event was statistically significant compared to the 2 years previous to the double suicide. This was especially true for women older than 65 years. Hence, the almost enthusiastic kind of reporting about this event was apt to induce imitation suicides or a "Werther-effect."     

Learning and memory in S100-beta transgenic mice: an analysis of impaired and preserved function

S100-beta, a calcium-binding astrocytic protein from chromosome 21, has been implicated in CNS function generally and the hippocampus in particular. Elevated levels of S100-beta have been observed reliably in the brains of patients with Alzheimer's Disease and Down Syndrome. Groups of transgenic mice, carrying multiple S100-beta gene copies, and nontransgenic controls were administered a series of behavioral tests (delayed spatial and nonspatial non-matching-to-sample, radial arm maze, socially acquired food preference) that assessed a wide range of cognitive functions. Consistent with the widespread presence of S100-beta throughout the brain, transgenic mice exhibited learning or memory impairment on all tasks. The dementia-like cognitive profile of S100-beta mice represents a promising model for studying comparable cognitive deficits associated with neurodegenerative diseases.     

Conservative Theories of Classical Truth

Some axiomatic theories of truth and related subsystems of second-order arithmetic are surveyed and shown to be conservative over their respective base theory. In particular, it is shown by purely finitistically means that the theory PA ÷ "there is a satisfaction class" and the theory FS of [2] are conservative over PA.     

Anterior cingulate cortex activation is related to learning potential on the WCST in schizophrenia patients

The remediation of executive function in patients with schizophrenia is important in rehabilitation because these skills affect the patient's capacity to function in the community. There is evidence that instructional techniques can improve deficits in the Wisconsin Card Sorting Test (WCST) in some schizophrenia patients. We used a standard test/training phase/standard test format of the WCST to classify 36 schizophrenia patients as high-achievers, learners or non-retainers. All healthy controls performed as high-achievers. An event-related fMRI design assessed neural activation patterns during post-training WCST performance. Patients showed a linear trend between set-shifting related activation in the anterior cingulate cortex and learning potential, i.e. increased activation in high-achievers, a trend for increased activation in learners, and no activation in non-retainers compared to controls. In addition, activation in the temporoparietal cortex was highest in patients classified as learners, whereas in non-retainers activation was increased in the inferior frontal gyrus compared to controls and high-achieving patients. These results emphasize the relevance of the ACC's neural integrity in learning set-shifting strategies for patients with schizophrenia. Also, our results support the hypothesis that compensatory neural activation in patients with schizophrenia helps them to catch up with healthy controls on cognitive tasks.     

The multidimensionality of test anxiety: A test of different models

Abstract

Confirmatory factor analysis was employed to test the multidimensional structure of test anxiety. Starting with the traditional two-factor model, it was of interest whether additional dimensions could still be represented by a single higher-order factor of test anxiety or whether the additional dimensions represented correlates of test anxiety. The Revised Test Anxiety (RTA) scale and the German Test Anxiety Inventory (TAI-G) were combined collecting data from a binational sample of 218 American and 218 German university students. Considering the statistical and theoretical aspects of model fit, they indicated that a model consisting of three primary factors (worry, emotionality, and lack of confidence) fit the data best. While distraction and self-efficacy may be regarded as correlates of test anxiety, lack of confidence was substantiated as a component of test anxiety. Implications for the conceptualization of the content domain and hence area of test anxiety were discussed.     

Emotion regulation,disgust sensitivity,and psychophysiological responses to a disgust-inducing film

Abstract

Using a disgust-inducing film, Gross (1998) showed that the instruction to suppress mimic expression (suppression) triggered physiological arousal, while the instruction to think about the film in order to adopt a detached and unemotional attitude (reappraisal) reduced affective strain compared to a condition instructing subjects simply to watch the film (watch). The present paper investigates, if disgust sensitivity has a moderating role in this context. Physiological, subjective, and behavior responses were recorded in 120 males divided according to high/low disgust sensitivity who were exposed to the disgust-inducing film used by Gross. The instruction effects reported by Gross could not be replicated. However, high disgust-sensitive subjects were more physiologically and emotionally aroused than low disgust-sensitive subjects. Interactions between disgust sensitivity and the three film instructions can possibly be traced back to a repressive coping style of subjects with low disgust sensitivity.