Psychologisch-psychotherapeutische Interventionen bei onkologischen Erkrankungen

Psychooncological interventions reduce significantly anxiety, desperation, depression, and stress in cancer patients, and can often help to improve quality of life and to eliminate communicational problems which occur in the social environment as a consequence of the disease.Hardly any research regarding the complex connections in the brain between the emotional experience, the endocrine and the immunological systems has been done, but the few available investigations are promising. In the absence of methodologically sound studies, the question still remains unanswered if adjuvant psychological or psychotherapeutic interventions contribute to a better survival or not.Up to now there exist just as many studies supporting this hypothesis as refutations.     

Medical semiotics in the 18th century: A theory of practice?

Medical semiotics in the 18th century was more than a premodern form of diagnosis. Its structure allowed for the combination of empirically proven rules of instruction with the theoretical knowledge of the new sciences, employing the relation between the sign and the signified.     

„Krise der Medizin“ – Modelle der Reform

In the 1920s and early 1930s there was a heated debate about the importance of the natural sciences for medicine. Prominent physicians, such as Ferdinand Sauerbruch and Wilhelm His in Germany or Richard Cabot and Charles-Edward Amory Winslow in the USA criticized clinical practices, medical education and research for placing too much focus on the natural sciences and the somatic correlates of human disease and for neglecting the psychological and social dimensions. In spite of a similar diagnosis of the problem, the consequences drawn differed considerably between the German and US contexts: in Germany first steps towards the institutionalization of the new field of psychotherapy and psychosomatic medicine and, in parallel, a consolidation of previously existing approaches of complementary medicine were developed, whereas in the USA the discussions led to the introduction and strengthening of social sciences in medicine, particularly in the field of public health. This article reconstructs the historical debate as well as the proposed models of reform and discusses potential implications for present-day medicine.     

Truth and Reduction

The proof-theoretic results on axiomatic theories oftruth obtained by different authors in recent years are surveyed.In particular, the theories of truth are related to subsystems ofsecond-order analysis. On the basis of these results, thesuitability of axiomatic theories of truth for ontologicalreduction is evaluated.     

Atypical categorization in children with high-functioning autism spectrum disorder

Children with autism spectrum disorder process many perceptual and social events differently from typically developing children, suggesting that they may also form and recognize categories differently. We used a dot pattern categorization task and prototype comparison modeling to compare categorical processing in children with high-functioning autism spectrum disorder and matched typical controls. We were interested in whether there were differences in how children with autism use average similarity information about a category to make decisions. During testing, the group with autism spectrum disorder endorsed prototypes less and was seemingly less sensitive to differences between to-be-categorized items and the prototype. The findings suggest that individuals with high-functioning autism spectrum disorder are less likely to use overall average similarity when forming categories or making categorical decisions. Such differences in category formation and use may negatively impact processing of socially relevant information, such as facial expressions. A supplemental appendix for this article may be downloaded from http://pbr.psychonomic-journals.org/content/supplemental.     

Emotional and cognitive information processing: relations to behavioral performance and hippocampal long-term potentiation in vivo during a spatial water maze training in rats

Emotionality as well as cognitive abilities contribute to the acquisition and retrieval of memories as well as to the consolidation of long-term potentiation (LTP), a cellular model of memory formation. However, little is known about the timescale and relative contribution of these processes. Therefore, we tested the effects of weak water maze training, containing both emotional and cognitive demands, on LTP in the hippocampal dentate gyrus. The population spike amplitude (PSA)-LTP was prolonged in all rats irrespective of whether they memorized the platform position or not, whereas the field excitatory postsynaptic potential (fEPSP)-LTP was impaired in good learners and enhanced in poor learners. We then dissociated the behavioral performance of rats during the water maze task by principal component analysis and by means of stress hormone concentrations into underlying "emotional" and "cognitive" factors. PSA-LTP was associated with "emotional" and fEPSP-LTP with "cognitive" behavior. PSA-LTP was depotentiated after the blockade of corticosterone binding mineralocorticoid receptors (MRs) in trained animals, while fEPSP-LTP was unaffected. These results suggest that synaptic processing and encoding of emotional information in the hippocampal dentate gyrus is realized fast and further information transfer is detectable by the reinforcement of PSA-LTP, whereas that of cognitive memories is long lasting.     

Paradoxical cross-over due to attention to high or low spatial frequencies

The mechanisms underlying the right hemisphere's dominance for spatial and attentional functions lacks a comprehensively explanation. For example, perceptual biases, as observed in line bisection and related tasks, might be caused by an attentional asymmetry or by perceptual processes such as a specialization of the left and right hemisphere for high and low spatial frequencies (SFs), respectively. Here we used the gratingscales task to measure perceptual bias in SF judgements, and we cued participants' attention either to high or low SFs. Participants showed a leftward bias when comparing the high SF components of the stimulus, and a rightward bias when comparing the low SF components-opposite to what would be expected from a hemispheric lateralization for SFs. Two control experiments used different strategies to manipulate the width of the attentional window. However, we observed no influence on perceptual bias, thus ruling out the possibility that the results in Experiment 1 were due to differences in attentional window size. These data support the idea of an attentional asymmetry underlying perceptual bias. Our results provide novel support for the role of attentional asymmetry in perceptual biases.