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121.
Makhracheva-Stepochkina D Frey S Frey JU Korz V 《Neurobiology of learning and memory》2008,89(4):545-551
Long-term potentiation (LTP) and depression (LTD) are considered as cellular models for learning and memory. We studied the impact of holeboard training on LTP in the rat CA1 hippocampal region. In 7-week-old Wistar rats a recording electrode was chronically implanted into the hippocampal pyramidal cell layer of the CA1 of the right hemisphere and a stimulation electrode into the contralateral CA3 region.Two groups of animals received a spatial holeboard training of 10 or 15 trials over 2 days on a fixed pattern of baited holes. The last trial was performed 15 min after a primed burst stimulation of the contralateral CA3, which resulted in LTP in the ipsilateral CA1. A pseudo-trained group that received a 10 trial training with changing patterns of baited holes after each trial and a group that remained in the recording chambers during the experiments served as controls. Experimental rats significantly improved their spatial performance with increasing numbers of trials, indicated by decreasing times to pick up all food pellets and by decreasing numbers of reference memory errors. A learning-related impairment of CA1-LTP measured in both the population-spike amplitude as well as the fEPSP could be noted. These results show that specific (pattern-training), but not unspecific (pseudo-training) spatial information processing prior to electrical stimulation can severely affect LTP in hippocampal area CA1. 相似文献
122.
Solutions to semantic paradoxes often involve restrictions of classical logic for semantic vocabulary. In the paper we investigate the costs of these restrictions in a model case. In particular, we fix two systems of truth capturing the same conception of truth: (a variant) of the system KF of Feferman (The Journal of Symbolic Logic, 56, 1–49, 1991) formulated in classical logic, and (a variant of) the system PKF of Halbach and Horsten (The Journal of Symbolic Logic, 71, 677–712, 2006), formulated in basic De Morgan logic. The classical system is known to be much stronger than the nonclassical one. We assess the reasons for this asymmetry by showing that the truth theoretic principles of PKF cannot be blamed: PKF with induction restricted to non-semantic vocabulary coincides in fact with what the restricted version of KF proves true. 相似文献
123.
Anette Kersting Michael Reutemann Patricia Ohrmann Katharina Schütt Ute Wesselmann Matthias Rothermundt Thomas Suslow Volker Arolt 《Psychotherapeut》2001,46(5):301-308
Grief is a highly individualized process influenced by intrapsychic, interpersonal and social factors. The definition of normal and pathological grief is complicated by the variety of grief reactions. Empirical research indicates that pathological grief may be concerned considered as a separate entity. Two research groups developed empirically validated criteria with a special focus on the traumatic aspect of grief. The current state of research allows, however, in our opinion not the conclusion, that the proposed diagnostic criteria for complicated (Horowitz et al. 1997) or traumatic grief (Prigerson et al. 1999b) do not enclose all types of grief. Further empirical research on representative samples is necessary to validate previous findings and to differentiate specific subgroups of pathological grief. 相似文献
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This study compared the clinical rating scales from the Circumplex Model (CCRS), the McMaster Model of Family Functioning (MCRS) and the Family Health Scales (FHS). A central purpose was to investigate whether observational rating scales designed to measure family functioning can also be used to assess couple functioning. One hundred and sixty-six drug abusing women, receiving primary drug treatment in two metropolitan drug agencies in the southwest of the US, and their partners were videotaped while engaged in three couple tasks prior to receiving any treatment. The main findings indicated that all three rating scales have: (1) sufficient interrater reliability; (2) good construct validity, as reflected in factor analyses; and (3) very good convergent validity. However, there was some concern about whether these scales are as discriminating when measuring couples as they are when assessing families. 相似文献
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127.
This qualitative study explored the needs of Indian middle-class families for family therapy services. Four focus group interviews were conducted with middle-class parents in Madras, India. Participants were introduced to the concept and practice of family therapy and were encouraged to take a more active role in supporting the services they suggested. Participants identified problems faced by Madras middle class families and five different types of services that they were aware of. Three categories of need for family therapy were identified from the narratives of the participants. Several themes fit in each of the three categories. Implications for clinical application are discussed. 相似文献
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129.
Christoph Benzmüller Volker Sorge Mateja Jamnik Manfred Kerber 《Journal of Applied Logic》2008,6(3):318-342
Different reasoning systems have different strengths and weaknesses, and often it is useful to combine these systems to gain as much as possible from their strengths and retain as little as possible from their weaknesses. Of particular interest is the integration of first-order and higher-order techniques. First-order reasoning systems, on the one hand, have reached considerable strength in some niches, but in many areas of mathematics they still cannot reliably solve relatively simple problems, for example, when reasoning about sets, relations, or functions. Higher-order reasoning systems, on the other hand, can solve problems of this kind automatically. But the complexity inherent in their calculi prevents them from solving a whole range of problems. However, while many problems cannot be solved by any one system alone, they can be solved by a combination of these systems.We present a general agent-based methodology for integrating different reasoning systems. It provides a generic integration framework which facilitates the cooperation between diverse reasoners, but can also be refined to enable more efficient, specialist integrations. We empirically evaluate its usefulness, effectiveness and efficiency by case studies involving the integration of first-order and higher-order automated theorem provers, computer algebra systems, and model generators. 相似文献
130.
Previous functional magnetic resonance imaging (fMRI) studies investigating hemispheric dominance for language have shown that hemispheric specialization increases with age. We employed magnetoencephalography (MEG) to investigate these effects as a function of normal development. In sum, 22 healthy children aged 7-16 years were investigated using two language tasks: a verb-generation (VG) task and a vowel-identification (VI) task. Significant hemispheric differences were found for both tasks in cerebral language areas using oscillatory MEG spectral analyses, confirming the MEG's ability to detect hemispheric specialization for language in children. Additionally, a significant increase of this lateralization as a function of age was observed for both tasks. As performance in the VI task showed no correlation with age, this increase seems to be unrelated to performance. These results confirm an increase in hemispheric specialization as a function of normal brain maturation. 相似文献