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Vladimir Krstić 《Ratio》2018,31(3):312-320
Sorensen says that my assertion that p is a knowledge‐lie if it is meant to undermine your justification for believing truly that ~p, not to make you believe that p and that, therefore, knowledge‐lies are not intended to deceive. It has been objected that they are meant to deceive because they are intended to make you more confident in a falsehood. In this paper, I propose a novel account according to which an assertion that p is a knowledge‐lie if it is intended not to provide evidence that p but to make you stop trusting all testimonies concerning whether p (in a room full of obvious liars, you will trust no one), which is how they undermine your testimonial knowledge. Because they are not intended to provide evidence that bears on the truth of p, they are not intended to make you more confident in a falsehood; therefore, knowledge‐lies are not intended to deceive. This makes them a problem for the traditional account, which takes the intention to deceive as necessary for lying, and an interesting example of Kant's idea that allowing lies whenever one feels like it would bring it about that statements in general are not believed.  相似文献   
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A-type K+ channels are known to regulate neuronal firing, but their role in repetitive firing and learning in mammals is not well characterized. To determine the contribution of the auxiliary K+ channel subunit Kvβ1.1 to A-type K+ currents and to study the physiological role of A-type K+ channels in repetitive firing and learning, we deleted the Kvβ1.1 gene in mice. The loss of Kvβ1.1 resulted in a reduced K+ current inactivation in hippocampal CA1 pyramidal neurons. Furthermore, in the mutant neurons, frequency-dependent spike broadening and the slow afterhyperpolarization (sAHP) were reduced. This suggests that Kvβ1.1-dependent A-type K+ channels contribute to frequency-dependent spike broadening and may regulate the sAHP by controlling Ca2+ influx during action potentials. The Kvβ1.1-deficient mice showed normal synaptic plasticity but were impaired in the learning of a water maze test and in the social transmission of food preference task, indicating that the Kvβ1.1 subunit contributes to certain types of learning and memory.  相似文献   
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The use of a humorous therapeutic approach combined with drug therapy in the treatment of chronic schizophrenia patients institutionalized for protracted periods of time led to positive changes in their symptoms. The majority of the patients responded well to humorous interpretations. The patients felt that they had the option of adopting the doctor's humorous manner. This approach appealed to them and raised self-esteem; they likewise gained confidence in their own ability to form judgments. They cooperated better with the doctor in issues pertaining to treatment. The fact that humor made an impact on the patients' cognition demonstrated that patients with disturbed thought processes could be influenced in ways which improved coping. The patients' condition was evaluated according to the BPRS scale, before the treatment, on a monthly basis during the treatment, and three months upon the completion of the experiment. In the course of the experiment, pharmacological treatment remained unchanged. On the average, a perceptible reduction in the BPRS value (p < .05) was detected as a result of humor therapy. Amusing representations of affective external stimuli were incorporated into the patients' cognition and, along with a newly gained awareness of the possibility of relating to them with humor, were retained long after the termination of the project.  相似文献   
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Constructivist and narrative psychotherapies share an understanding of the self as fragmented, relational, distributed, and discursive. Collaboration of these two modalities might offer a synergistic perspective for working with people. Hermeneutically driven therapy concerns personal development, which is seen as a unique effort of the individual to narrate different stories about him- or herself and others. The therapeutic process is viewed as a raising of awareness about marginalized discourses and empowering alternative voices. Furthermore, the making of an alternative story implies a new understanding of oneself, new interpretation of the past, and anticipation of the future. A case study is presented in which these principles are implemented in therapeutic practice.  相似文献   
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