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101.
Lazaroni TL Raslan AC Fontes WR de Oliveira ML Bader M Alenina N Moraes MF Dos Santos RA Pereira GS 《Neurobiology of learning and memory》2012,97(1):113-123
It has been shown that the brain has its own intrinsic renin-angiotensin system (RAS) and angiotensin-(1-7) (Ang-(1-7)) is particularly interesting, because it appears to counterbalance most of the Ang II effects. Ang-(1-7) exerts its biological function through activation of the G-protein-coupled receptor Mas. Interestingly, hippocampus is one of the regions with higher expression of Mas. However, the role of Ang-(1-7)/Mas axis in hippocampus-dependent memories is still poorly understood. Here we demonstrated that Mas ablation, as well as the blockade of Mas in the CA1-hippocampus, impaired object recognition memory (ORM). We also demonstrated that the blockade of Ang II receptors AT1, but not AT2, recovers ORM impairment of Mas-deficient mice. Considering that high concentrations of Ang-(1-7) may activate AT1 receptors, nonspecifically, we evaluate the levels of Ang-(1-7) and its main precursors Ang I and Ang II in the hippocampus of Mas-deficient mice. The Ang I and Ang II levels are unaltered in the whole hipocampus of MasKo. However, Ang-(1-7) concentration is increased in the whole hippocampus of MasKo mice, as well as in the CA1 area. Taken together, our findings suggest that the functionality of the Ang-(1-7)/Mas axis is essential for normal ORM processing. 相似文献
102.
Lovatel GA Bertoldi K Elsner VR Vanzella C Moysés Fdos S Spindler C Funck VR Pereira LM de Oliveira CV Oliveira MS Netto CA Siqueira IR 《Neurobiology of learning and memory》2012,98(2):182-187
Exercise induces brain function adaptations and improves learning and memory; however the time window of exercise effects has been poorly investigated. Studies demonstrate an important role for cyclooxygenase-2 (COX-2) pathway function in the mechanisms underlying memory formation. The aim of present work was to investigate the effects of treadmill exercise on aversive memory and COX-2, PGE(2) and E-prostanoid receptors contents in the rat hippocampus at different time points after exercise has ended. Adult male Wistar rats were assigned to non-exercised (sedentary) and exercised (running daily for 20min, for 2weeks) groups. The inhibitory avoidance task was used to assess aversive memory and the COX-2, PGE(2) and E-prostanoid receptors (EP1, EP2, EP3 and EP4) levels were determined 1h, 18h, 3days or 7days after the last training session of treadmill exercise. The step down latency in the inhibitory avoidance, COX-2 and EP4 receptors levels were acutely increased by exercise, with a significant positive correlation between aversive memory performance and COX-2 levels. Increased EP2 content decreased PGE(2) levels were observed 7days after the last running session. The treadmill exercise protocol facilitates inhibitory avoidance memory and induces time-dependent changes on COX-2 pathways function (COX-2, PGE(2) and EP receptors). 相似文献
103.
Penner Francesca Elzaki Yasmin Contreras Haglaeeh T. Santos Roberto P. Sarver Dustin E. 《Journal of abnormal child psychology》2022,50(9):1121-1138
Research on Child and Adolescent Psychopathology - The COVID-19 pandemic has led to increased mental health concerns, including depression and anxiety among parents and internalizing and... 相似文献
104.
Manuela Romo Santos 《Estudios de Psicología》2013,34(18):43-46
RESUMENTanto en la perspectiva diferencial como en el análisis cognitivo o más ligado a la “psicología general”, el problema de la creatividad ha preocupado a los psicólogos durante décadas. Bajo la etiqueta general de “creatividad” se sitúan algunos de los interrogantes más apasionantes que se pueden estudiar en psicología: Definición de creatividad, procesos implicados en la creatividad, la existencia de diferencias individuales. En este artículo se hace una revisión sumaria de las distintas teorías del proceso creador de Bus y Mansfield, que han intentado dar cuenta de los interrogantes antes mencionados. 相似文献
105.
M. Romo Santos 《Estudios de Psicología》2013,34(18):81-99
ResumenSe plantea un intento de síntesis teórica y empírica entre dos aproximaciones al estudio del pensamiento creador: la asociativa y ta factorial.Tras el análisis de las teorías de Mednick y Guilford como los modelos más sistemáticos en ambas orientaciones se realizó un estudio factorial con tres muestras de sujetos representativos de tres contenidos de pensamiento definidos en el modelo de Guilford: periodistas (contenido semántico), matemáticos (contenido simbólico) y pintores (contenido figurativo). Junto a una selección de tareas de la batería de Guilford para la medida del pensamiento divergente correspondientes a las tres áreas de información evaluadas, se aplicó el RAT de Mednick a los 171 sujetos. Se realizaron cuatro análisis factoriales, uno global y los otros diferenciando por grupos de sujetos.Los resultados fueron una confirmación de la teoría factorial de la creatividad de Guilford, al definirse factorialmente tres aptitudes perfectamente diferenciadas en función de los contenidos, pero no se pudo confirmar la naturaleza asociativa de las aptitudes mentales de creatividad en los términos propuestos por Mednick, dada la ausencia de resultados significativos con respecto al RAT. Las conclusiones de este trabajo son inequívocamente confirmadoras de la versión propuesta en las hipótesis de la teoría de Guilford. 相似文献
106.
Andre Santos Campos 《International Journal of Philosophical Studies》2013,21(4):498-514
ABSTRACTA much debated passage in the Metaphysics of Morals often leads commentators to believe that it is not possible to act from juridical duty. On the one hand, Kant says that all lawgiving includes an incentive ‘which connects a ground to determining choice to this action subjectively with the representation of the law’ (MM: 218). On the other hand, he claims that juridical lawgiving ‘does not include the incentive of duty in the law’ (MM: 219). The first claim seems to entail that agents can perform a juridical duty for the sake of that duty; the second seems to entail that agents cannot perform a juridical duty for the sake of that duty. This paper shows that it is possible to reconcile both passages and to claim that one can act from juridical duty in Kant’s terms. First, it gives an account of what can be called the paradox of juridical duties. Second, it discusses briefly how responses to the paradox remain somewhat unsatisfactory. Finally, it clarifies how agents can act with no other incentive but the actual juridical duty without endangering the Kantian morality-law divide. 相似文献
107.
M. Moura-Ramos S. Gameiro M.C. Canavarro I. Soares T.A. Santos 《Psychology & health》2013,28(5):533-549
Few studies were dedicated to study the role of contextual factors, such as the socioeconomic status and urban or rural residence in emotional distress of infertile couples. This study aimed to explore the impact of contextual factors on emotional distress, either directly or by affecting the importance of parenthood in one's life, which in turn affects emotional distress. In this cross-sectional study, 70 couples recruited during hormonal stimulation phase prior to in vitro fertilisation completed clinical and sociodemographic forms and self-report questionnaires assessing representations about the importance of parenthood and emotional distress. Path analysis using structural equation modelling was used to examine direct and indirect effects among variables. Results indicated that socioeconomic status and place of residence had an impact in emotional distress by affecting the representations about the importance of parenthood in one's life. Gender differences were found regarding model paths, suggesting that the social context may have a stronger influence on women's emotional distress than on their partners’ distress. When delineating psychological interventions, health care providers should consider that cultural values about children and parenthood contribute to shape the infertility experience. 相似文献
108.
Catarina Marques Santos Sjir Uitdewilligen Ana Margarida Passos 《European Journal of Work and Organizational Psychology》2015,24(5):710-725
In this longitudinal study, we integrated a team process and a learning curve perspective on team learning and empirically analysed whether team learning processes lead to performance improvement. In addition, we tested whether this relation is moderated by the similarity of team members’ task, team, and temporal mental models. We tested our model on a sample of 67 teams (314 individuals) competing in a management simulation over five consecutive time periods, using random coefficient modelling (RCM). Our findings suggest that team learning behaviours do not have a direct effect on the team learning curve, but temporal and task mental models are crucial for the translation of team learning behaviours into performance improvement. We found that when teams have similar task and temporal mental models, engaging in team learning processes is beneficial, whereas, when teams have dissimilar task and temporal mental models, it is detrimental to performance improvement. We did not find a significant effect for the moderating role of team mental model similarity. Our study emphasizes the importance of integrating different perspectives on team learning and provides support for the role of team cognition as a catalyst for team learning. 相似文献
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