瓜蒌皮与前列地尔预处理对心肌缺血再灌注的影响

探讨瓜蒌皮和前列地尔预处理对心肌缺血再灌注的作用机制.通过建立SD大鼠心肌缺血再灌注的模型,采用Tunel法检测组织样本细胞凋亡和免疫组化法检测bax,bcl-2,caspase-3的蛋白表达情况进行研究.结果显示,瓜蒌皮和前列地尔半剂量联合组的凋亡细胞数、Bax和caspase-3的蛋白表达量较其他各实验组均明显降低,Bcl-2的表达量升高,且有统计学意义(P＜0.05);瓜蒌皮单用药组也表现为凋亡细胞数、Bax和caspase-3的表达量降低,Bcl-2的表达量升高,但程度不如两组联合用药组.实验可以证明细胞凋亡发生在心肌缺血/再灌注损伤中,瓜蒌皮可对心肌缺血/再灌注起保护作用,并且与前列地尔联合后更有利于对心肌细胞的保护作用.     

‘Drinking is our modern way of bonding’: Young people’s beliefs about interventions to encourage moderate drinking

Efforts to discourage excessive alcohol use among young people can only be effective if the target audience is exposed to, attends to, and comprehends key messages. The aim of this study was to examine age and sex differences in drinking motives to better inform development of targeted interventions to reduce alcohol-related harm. Thirty individual interviews and 12 group interviews were conducted with English 13–25?year olds. Interviewees gave multiple motivations for drinking – especially those related to image and reputation, and played down the health implications of heavy drinking. Negative aspects of drinking – caring for drunk friends, being cared for when drunk and suffering through hangovers with friends – were considered to offer opportunities for closer interpersonal bonding than other social activities. Respondents distanced themselves from ‘problem’ drinkers, but disapproved of others’ problematic drinking or antisocial behaviour. Narrative messages demonstrating the social consequences of excessive consumption were preferred to single, static messages emphasising risk or harm. Interviewees noted that interventions must use an engaging tone or pitch: they considered many campaigns to be patronising or preaching. A lack of consensus between age and sex groups highlighted a need for multifaceted, multi-modal approaches that utilise mobile technologies and new media.     

Emerging perspectives on the structure and function of attitude strength

For more than 20 years, scholars have used the term “attitude strength” to refer to the durability and impactfulness of attitudes, and a large literature attests to the important leverage that this concept offers for understanding and predicting behaviour. Despite its prominence, however, a number of fundamental questions remain regarding the structure and function of attitude strength. In this chapter we draw on a wide range of evidence to clarify the nature of attitude strength. Rather than conceiving of attitude strength as a meaningful psychological construct, we argue that it is better conceptualised as an umbrella term that refers in only the most general way to multiple, separable classes of attitude outcomes, instigated by different antecedents and produced by distinct psychological processes. Although strong attitudes share a set of general qualities—resistance to change, persistence over time, impact on thought and behaviour—there are many distinct routes by which attitudes come to possess these qualities, and many diverse ways in which these qualities manifest themselves. Our analysis shifts the focus away from the structural properties of attitude strength and towards a fuller appreciation of the distinct sources from which attitudes derive their strength. We argue in particular for the value of attending more closely to the social bases of attitude strength, and we illustrate the value of this approach by reviewing several lines of research.     

I’ll Never Forgive You: High Conflict Divorce,Social Network,and Co-Parenting Conflicts

The relation between divorce, co-parenting conflicts, and children’s adjustment problems has been well established. An unresolved question for research and clinical interventions, however, is how conflicts between parents are maintained and/or escalate. This cross-sectional research tested the hypothesis that co-parenting conflicts in divorced couples are associated with perceived social network disapproval and that this relation is mediated by parents’ tendency to forgive each other. In Study 1, a convenience sample of 136 divorced parents recruited via online forums, we showed that perceived social network disapproval was indeed positively related to co-parenting conflicts and that parents’ tendency to forgive the other parent—albeit partly—explained this relationship. Strength of our research is that in Study 2, 110 parents referred to children’s mental health care because the wellbeing of the children was severely compromised by the severity of the conflicts between parents, we replicated these results. In both studies perceived social network disapproval and co-parenting conflicts were positively related and this link was mediated by forgiveness: perceived social network disapproval was negatively related to forgiveness, which in turn was negatively related to more parental conflicts.     

Training and the attentional blink: Raising the ceiling does not remove the limits

The attentional blink (AB) is a widely studied deficit in reporting the second of two sequentially presented targets when they occur within 500 milliseconds. The AB often is interpreted to index a structural limit in sequential visual processing. However, this interpretation is challenged by reports that the deficit can be reduced with several hundred trials of specific training (Braun in Nature, 393(6684), 424–425, 1998; Choi et al. in Proceedings of the National Academy of Sciences, 109(30), 12242–12247, 2012; Taatgen et al. in Cognitive Psychology, 59(1), 1–29, 2009) and other reports that some individuals experience very little or no deficit, even without specific training (Martens et al. in Journal of Cognitive Neuroscience, 18(9), 1423-1438, 2006). Yet neither of these claims has been studied when the artifact of ceiling effects has been removed. We sent a small number of participants (n = 5) home to practice an AB task on their mobile phones for 3,000-6,000 trials (Experiment 1) and trained a much larger number of participants (n = 48) in a similar way for 1,200-1,800 trials (Experiment 2). Both experiments used adaptive procedures to equate task difficulty throughout training to keep second-target accuracy below ceiling levels. The results showed strong training effects on the rate of processing sequential information. Despite this, there were (a) robust AB effects after training for most participants, (b) no benefit for training on difficult versus easy target tasks, and (c) substantial correlations between the magnitude of the AB before and after extensive training. These findings support the interpretation that the AB is an index of a structural limit in the ability to consciously process rapid visual sequences.     

The role of reversal frequency in learning noisy second order conditional sequences

The hallmark of implicit learning is that complex knowledge can be acquired unconsciously. The second order conditionals (SOCs) of Reed and Johnson (1994) were developed to be complex, and they are popular materials for implicit learning research. Recently, it was demonstrated that in a sequence made noisy (by combining two SOCs), shared features of the SOCs may be learned explicitly (Fu, Fu, & Dienes, 2008). What are these shared features? We hypothesized that low reversal frequency may play a significant role. We have varied reversal frequency, and discovered that reversal frequency affected response times, inclusion exclusion behavior, and recognition ratings. Not only does it appear to be important to distinguish implicit and explicit knowledge, but also to distinguish what the knowledge is of.     

The impact of the social context on resistance to persuasion: Effortful versus effortless responses to counter-attitudinal information

Past research has demonstrated that the presence of attitudinal diversity within a person’s social network increases his or her openness to attitude change. The current research explores whether this increased openness to attitude change is the result of relatively thoughtful or nonthoughtful processes. A nationally representative sample of US adults was exposed to a counter-attitudinal persuasive message that contained either strong or weak arguments. Attitudinal diversity within participants’ social networks was associated with greater argument quality differentiation: people embedded in networks that included a variety of views were more likely than those in attitudinally homogenous networks to carefully scrutinize attitude-relevant information, modifying their attitudes in response to strong but not weak arguments.     

环境基因组计划(EGP)对预防医学发展的影响

1998年美国正式启动环境基因组计划,该计划旨在探讨环境－基因的交互作用,寻找对环境因素损伤的易感基因及环境反应基因的多态性在疾病病因和发病过程中的作用,因而该计划的实施将对预防医学的发展产生重要的影响。     

The attentional blink with targets in different spatial locations

When two targets (T1 and T2) are displayed in rapid succession, accuracy of T2 identification varies as a function of the temporal lag between the targets (attentional blink, AB). In some studies, performance has been found to be most impaired at Lag 1—namely, when T2 followed T1 directly. In other studies, T2 performance at Lag 1 has been virtually unimpaired (Lag 1 sparing). In the present work, we examined how Lag 1 sparing is affected by attentional switches between targets displayed in the same location or in different locations. We found that Lag 1 sparing does not occur when a spatial shift is required between T1 and T2. This suggests that attention cannot be switched to a new location while the system is busy processing another stimulus. The results are explained by a modified version of an attentional gating model (Chun & Potter, 1995; Shapiro & Raymond, 1994).