Transgenic inhibition of neuronal calcineurin activity in the forebrain facilitates fear conditioning, but inhibits the extinction of contextual fear memories

It is unclear whether protein phosphatases, which counteract the actions of protein kinases, play a beneficial role in the formation and extinction of previously acquired fear memories. In this study, we investigated the role of the calcium/calmodulin dependent phosphatase 2B, also known as calcineurin (CaN) in the formation of contextual fear memory and extinction of previously acquired contextual fear. We used a temporally regulated transgenic approach, that allowed us to selectively inhibit neuronal CaN activity in the forebrain either during conditioning or only during extinction training leaving the conditioning undisturbed. Reducing CaN activity through the expression of a CaN inhibitor facilitated contextual fear conditioning, while it impaired the extinction of previously formed contextual fear memory. These findings give the first genetic evidence that neuronal CaN plays an opposite role in the formation of contextual fear memories and the extinction of previously formed contextual fear memories.     

Phobic tendency within the Five-Factor and HEXACO models of personality structure

Recent research has indicated that the various specific phobias are only modestly correlated with the personality dimensions of the Big Five or Five-Factor Model (B5/FFM). We tested the hypothesis that the specific phobias would be more strongly associated with the dimensions of an alternative framework, the HEXACO model of personality structure. Self-reports on the Phobic Stimuli Response Scales (PSRS) were obtained along with self- and peer reports on measures of the B5/FFM and HEXACO dimensions from a sample of 248 non-clinical participants. The PSRS variables assessing specific phobias showed stronger correlations with the HEXACO Emotionality factor than with any B5/FFM dimension, and a stronger multiple correlation with the HEXACO factors than with the B5/FFM dimensions. Findings were similar across self- and peer reports of the personality variables. The results suggest that phobic tendency can be understood in terms of normal personality variation as conceptualized in the HEXACO framework.     

Attitude Importance: Understanding the Causes and Consequences of Passionately Held Views

People care passionately about some attitudes and consider them deeply important, and they accord no particular significance to other attitudes. In the current paper, we review the state of the psychological literature on attitude importance. We consider the factors that cause people to attach importance to some attitudes but not to others, and we review the cognitive, affective, and behavioral consequences of attaching importance to an attitude. Finally, we explore several open questions regarding attitude importance, charting a course for future research in this area.     

Testing overall and moderator effects in random effects meta‐regression

Random effects meta‐regression is a technique to synthesize results of multiple studies. It allows for a test of an overall effect, as well as for tests of effects of study characteristics, that is, (discrete or continuous) moderator effects. We describe various procedures to test moderator effects: the z, t, likelihood ratio (LR), Bartlett‐corrected LR (BcLR), and resampling tests. We compare the Type I error of these tests, and conclude that the common z test, and to a lesser extent the LR test, do not perform well since they may yield Type I error rates appreciably larger than the chosen alpha. The error rate of the resampling test is accurate, closely followed by the BcLR test. The error rate of the t test is less accurate but arguably tolerable. With respect to statistical power, the BcLR and t tests slightly outperform the resampling test. Therefore, our recommendation is to use either the resampling or the BcLR test. If these statistics are unavailable, then the t test should be used since it is certainly superior to the z test.     

Is all sparing created equal? Comparing lag-1 sparing and extended sparing in temporal object perception

When two targets (T1, T2) are presented amongst a rapid stream of distractors, T2 accuracy is impaired if the targets are separated by at least one distractor (attentional blink). However, this impairment largely disappears if the targets follow one another directly (lag-1 sparing), and, in fact, as many as four or five consecutive targets may be identified quite accurately under these conditions (extended sparing). Although all current models propose a common mechanism for both lag-1 and extended sparing, this hypothesis has yet to be tested. To this end, we examined the effect of various types of attentional switches, known to impact lag-1 sparing, on extended sparing in order to determine whether they would have a similar effect. Results suggested substantial parallels between the two types of sparing. We discuss these results in terms of a unified account of sparing in temporal object perception.     

Stigmatizing attitudes of the community towards people living with HIV/AIDS

This research involved an exploratory study in which a questionnaire was used to investigate the personal stigma and perceived community stigma regarding HIV/AIDS in a South African community. Student fieldworkers interviewed a convenient sample of 901 respondents from different races, gender and age groups, and found that respondents tended towards stigmatizing persons with HIV/AIDS. Yet, this degree of stigmatization was significantly less severe than the degree of stigmatization that respondents attributed to the community at large. Altogether 17% of the respondents had high stigmatizing attitudes, while 42% perceived the stigmatization by others in the community to be high. Race group, personal knowledge of someone with HIV, area of residence, gender and age group impacted on the respondents' personal tendency to stigmatize those with HIV/AIDS. The article discusses the difference between the level of personal stigma attached by the respondents and that perceived by them to be attached by the community. Attention is also paid to the possible implications of stigmatizing behaviour patterns and interventions on a community level. Copyright © 2006 John Wiley & Sons, Ltd.     

Hypochondriacs' estimation of negative outcomes: domain-specificity and responsiveness to reassuring and alarming information

Based on hypochondriacal patients' tendency to overestimate the seriousness of bodily sensations and health risks [Barsky, A. J., Wyshak, G. & Klerman, G. L. (1990). The Somatosensory Amplification Scale and its relationship to hypochondriasis. Journal of Psychiatric Research, 24, 323-334; Warwick, H. M. C., & Salkovskis, P. M. (1990). Hypochondriasis. Behaviour Research and Therapy, 28, 105-117], we investigated whether hypochondriacal individuals (n = 20) are inclined to report higher estimates of negative outcomes than healthy controls (n = 20) when interpreting ambiguous health-related and nonhealth-related events. In addition, we explored the influence of additional reassuring and alarming information on hypochondriacs' estimates of negative outcomes. Following the cognitive-behavioural model of hypochondriasis [Warwick, H. M. C. & Salkovskis, P. M. (1989). Hypochondriasis. In J. Scott, J. M. G. Williams & A. T. Beck (Eds.), Cognitive therapy in clinical practice: an illustrative casebook. (pp. 78-102). London: Routledge] we hypothesized that hypochondriacal individuals would be more responsive to alarming information and less responsive to reassuring information than healthy controls. Yet, hypochondriacs were neither found to be immune for reassuring information, nor to be hypersensitive to alarming information. Meanwhile, irrespective of the additional alarming or reassuring information, hypochondriacs clearly showed a domain-specific bias towards higher estimates of negative outcomes in ambiguous health-related situations.     

Direct estimates of processing delays in the attentional blink

 When two targets (T1 and T2) are presented in rapid succession, identification of T2 is often impaired (attentional blink: AB). The two-stage model accounts for the AB deficit by assuming that: (a) T2 is delayed in Stage 1 while Stage 2 is busy processing T1, and (b) T2 is vulnerable to masking while delayed. We report converging evidence for the model by evaluating these assumptions independently of the AB deficit itself. The results show that: (a) response times for T2 identification decreased as the lag between T1 and T2 was increased; (b) response times for T2 decreased across lags only if T1 was masked; and (c) accuracy of T2 identification increased as the stimulus-onset asynchrony between T2 and the trailing mask was increased. Received: 4 February 1999 / Accepted: 26 July 1999     

Gregory Bateson on deutero-learning and double bind: a brief conceptual history

The concepts of deutero-learning and double bind have acquired an increasingly important status in various fields of social and behavioral science, particularly in psychiatry, psychotherapy, organization, and policy science. With this proliferation, however, their original meaning and significance has become increasingly muted. In this article it is argued that both concepts are important ingredients of a behavioral theory of (organizational) learning. To support this argument, the development of both concepts is traced to the work of Gregory Bateson. In Bateson's thinking, the two concepts have a firm base in dyadic behavior and interaction.