Dexamethasone and stressor-magnitude regulation of stress-induced transcription of HPA axis secretagogues in the rat

Regulation of the production of hypothalamic-pituitary-adrenal (HPA) axis secretagogues, corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP), may be differentially sensitive to the negative feedback effects of glucocorticoids. We chose to study this phenomenon by examining the ability of dexamethasone to influence CRH and AVP heteronuclear RNA (hnRNA) levels in an escapable/inescapable (ES/IS) foot-shock stress paradigm. On Day 1, adult male rats were subjected to either ES or IS foot-shock; on Day 2, saline or dexamethasone (100 microg/kg) was administered 2 h prior to the stressor. We found that ES/IS foot-shock stimulated similar robust increases in plasma adrenocorticotrophic hormone (ACTH) and corticosterone concentrations, and medial parvocellular division of the paraventricular nucleus (mpPVN) AVP and CRH hnRNA and c-fos mRNA levels in saline-treated ES/IS rats. Dexamethasone pretreatment suppressed ACTH and corticosterone levels similarly in IS and ES animals. Dexamethasone pretreatment also suppressed mpPVN CRH and AVP hnRNA levels at 30 min. However, by 120 min, the mpPVN AVP hnRNA levels in dexamethasone-treated rats were similar to those measured in the saline group. We also found that rats that received the most shocks on Day 1 had greater HPA axis activation on Day 2. We conclude that the magnitude of the foot-shock stressor, determined by learned and immediate cues, is important in determining the magnitude of the HPA response.     

Caregiver Involvement in the Intensive Mental Health Program: Influence on Changes in Child Functioning

We examined behavioral markers of caregiver involvement and the ways in which family participation was related to treatment outcomes in 47 elementary school children with SED enrolled in a school-based intensive mental health program. Measures of caregiver involvement included therapeutic home visits, attendance at therapeutic meetings, completion of ratings on the daily point sheet, and extra communications with the therapeutic team on the point sheet. Greater initial impairment was associated with greater caregiver involvement. Greater caregiver involvement was linked to improvement in child thought processes, increased ability to provide emotional and social supports for the child, and greater overall child functioning at discharge. Our findings also reflected increased therapists’ attempts to provide additional in-home services in cases where caregivers demonstrated a decline in their ability to provide for their children’s physical and material needs, or in which therapists discovered that the family functioning was more impaired than what was initially assessed. We provide a case study that exemplifies many of these findings.     

Coping with Crisis Across the Lifespan: The Role of a Telephone Hotline

We describe over 300,000 crisis calls made to a large national hotline over a 5-year period. Callers consisted of males and females between the ages of 10 and 89. Overall, a slight majority of callers were first time callers (52%) and most (73%) sought assistance with issues related to parenting, youth concerns, and mental health. Across the lifespan, issues dealing with loneliness increased with age whereas depression-related calls decreased. Additionally, females were more likely than their male counterparts to call the hotline by over a 2- to 1-margin. Findings lend preliminary support to the efficacy of crisis call centers to utilize a flexible, yet well-defined problem-solving approach to assist those of all ages calling with the wide range of problems.     

APPLIED MYSTICISM: A DRUG‐ENABLED VISIONARY EXPERIENCE AGAINST MORAL BLINDNESS

Intellectuals such as William James and Aldous Huxley have thought it possible to develop a technique to apply to this world the mystical‐type insights gained during drug‐enabled experiences. Particularly, Huxley claimed that the visionary experience triggered by psychedelics could help us rethink our relationship with technology and promote a much‐needed cultural change. In this article, we explore this hypothesis. To do so, we build a philosophical framework based on Günther Anders's philosophy of technique, presenting human beings as morally blind when facing technological development. Mystical experiences are then proposed as a means to improve our moral faculties—and psychedelic drugs as tools to enable them. We finally explore the empirical feasibility of such a hypothesis by thoroughly reviewing the recent scientific literature on the nature of the psychedelic experience, concluding that the long‐term effects in the personality domain openness and in nature relatedness point to the emergence of a morally improved agent, thus providing substance to an application of mysticism.     

In the footsteps of biological motion and multisensory perception: judgments of audiovisual temporal relations are enhanced for upright walkers

Observers judged whether a periodically moving visual display (point-light walker) had the same temporal frequency as a series of auditory beeps that in some cases coincided with the apparent footsteps of the walker. Performance in this multisensory judgment was consistently better for upright point-light walkers than for inverted point-light walkers or scrambled control stimuli, even though the temporal information was the same in the three types of stimuli. The advantage with upright walkers disappeared when the visual "footsteps" were not phase-locked with the auditory events (and instead offset by 50% of the gait cycle). This finding indicates there was some specificity to the naturally experienced multisensory relation, and that temporal perception was not simply better for upright walkers per se. These experiments indicate that the gestalt of visual stimuli can substantially affect multisensory judgments, even in the context of a temporal task (for which audition is often considered dominant). This effect appears to be constrained by the ecological validity of the particular pairings.     

Morningness/eveningness, morning-to-afternoon cortisol ratio, and antisocial behavior problems during puberty

The relationship between morningness/eveningness (M/E) and morning-to-afternoon cortisol ratio, pubertal timing, and antisocial behavior was examined in 111 girls and boys ages 8 to 13 years. Cortisol levels showed a significant increase after awakening and declined thereafter (p<.05). Eveningness was related to a composite measure of antisocial behavior and rule-breaking and attention behavior problems and conduct disorder (CD) symptoms in boys and relational aggression in girls. In boys only, lower a.m. to p.m. cortisol ratio, indicating less circadian decrease in cortisol, was related to attention problems. Early pubertal timing was associated with boys' rule-breaking and attention behavior problems and CD symptoms and girls' relational aggression. The findings indicate that evening activity preference; extreme a.m. to p.m. cortisol ratios, in one case; and early pubertal timing were associated with antisocial behavior even in young adolescents, but the findings were stronger for boys than for girls.     

An Examination of the Psychometric Properties and Factor Structure of the Feelings of Stigmatization Questionnaire

As the experience of stigma and its psychological dimensions require careful measurement, the purpose of this study was to examine the psychometric properties and factor structure of the Feelings of Stigmatization Questionnaire (FSQ). A total of 170 participants with psoriasis and 124 with atopic dermatitis (AD) completed the FSQ. AD participants self-rated AD severity, while psoriasis severity was determined by a clinician. Confirmatory (CFA) and exploratory factor analytic (EFA) techniques were used to examine the factor structure of the FSQ. The FSQ total score was not related to age, age at onset, illness duration or psoriasis severity but it was negatively associated with AD severity (r = −.25, p < .01). The original six-factor structure of the FSQ was not replicated in our sample. Using EFA, a fixed three-factor solution proved the most stable, with the dimensions of feeling flawed, anticipation of rejection and secrecy, and positive attitudes towards skin disease being identified.     

Examining posttraumatic growth among Japanese university students

To determine the underlying factor structure of the Japanese version of the Posttraumatic Growth Inventory (PTGI-J), a principal components analysis was performed on data from 312 Japanese undergraduate students who reported growth due to their most traumatic event within the last 5 years. Results showed the PTGI-J has high internal consistency and, of the original five factors reported by Tedeschi and Calhoun (1996), three were replicated: Relating to Others, New Possibilities, Personal Strength, and a fourth factor integrating Spiritual Change and Appreciation of Life emerged. There were neither gender differences nor relationships with time since trauma. PTGI-J scores were positively associated with posttraumatic symptoms and correlated with type of traumatic event experienced. These results and future directions are discussed from a cross-cultural viewpoint.