Effects of MK-801 and ethanol combinations on memory consolidation in CD1 mice: involvement of GABAergic mechanisms

In the present research the effect of the noncompetitive N-methyl-d-aspartate receptor antagonist MK-801 and ethanol combinations on memory consolidation and the involvement of GABAergic mechanisms in this effect were investigated in CD1 mice injected intraperitoneally with the drugs immediately or 120 min after training in a one-trial inhibitory avoidance apparatus and tested for retention 24 h later. The results showed that (a) the retention performances of mice were impaired in a dose-dependent manner by immediate posttraining MK-801 (0.2 and 0.3, but not 0.1 mg/kg) and ethanol (1 and 2, but not 0.5 g/kg) administrations; (b) an otherwise ineffective dose of MK-801 (0.1 mg/kg) enhanced the deleterious effect exerted by ethanol (1 and 2 g/kg); (c) an otherwise ineffective dose of muscimol (0.5 mg/kg) enhanced, while otherwise ineffective doses of picrotoxin (0.25 mg/kg) or bicuculline (0.1 mg/kg) antagonized, this effect; and (d) no effect was observed when the treatments were carried out 120 min after training, suggesting that the effects observed following immediate posttraining administrations were due to the influence on the consolidation of memory. From these experiments it is evident that (a) MK-801 enhances ethanol's effects on memory consolidation and (b) GABAergic mechanisms are involved in this effect.     

Book Review: Ecological rationality and its heuristics

In this study both adolescents with autism spectrum disorder (ASD) and typically developing controls were presented with conditional reasoning problems using familiar content. In this task both valid and fallacious conditional inferences that would otherwise be drawn can be suppressed if counterexample cases are brought to mind. Such suppression occurs when additional premises are presented, whose effect is to suggest such counterexample cases. In this study we predicted and observed that this suppression effect was substantially and significantly weaker for autistic participants. We take this as evidence that autistics are less contextualised in their reasoning, a finding that can be linked to research on autism on a variety of other cognitive tasks.     

On the Logical Form of Concessive Conditionals

This paper outlines an account of concessive conditionals that rests on two main ideas. One is that the logical form of a sentence as used in a given context is determined by the content expressed by the sentence in that context. The other is that a coherent distinction can be drawn between a reading of ‘if’ according to which a conditional is true when its consequent holds on the supposition that its antecedent holds, and a stronger reading according to which a conditional is true when its antecedent supports its consequent. As we will suggest, the logical form of concessive conditionals can be elucidated by relying on this distinction.

     

On the conjunction fallacy and the meaning of and, yet again: a reply to Hertwig, Benz, and Krauss (2008)

In this paper we question the theoretical tenability of Hertwig, Benz, and Krauss's (2008) (HBK) argument that responses commonly taken as manifestations of the conjunction fallacy should be instead considered as reflecting "reasonable pragmatic and semantic inferences" because the meaning of and does not always coincide with that of the logical operator ∧. We also question the relevance of the experimental evidence that HBK provide in support of their argument as well as their account of the pertinent literature. Finally, we report two novel experiments in which we employed HBK's procedure to control for the interpretation of and. The results obtained overtly contradict HBK's data and claims. We conclude with a discussion on the alleged feebleness of the conjunction fallacy, and suggest directions that future research on this topic might pursue.     

Evaluation of the Effects of Prescribing Gait Complexity Using Several Fluctuating Timing Imperatives

Abstract

Variability in the temporal structure of gait patterns, measured by “Fractal Index” (FI), is thought to represent abundancy of movement patterns facilitating adaptive control of walking. However we do not know how FI changes according to different walking rhythms or if this is repeatable, as needed to exploit the paradigm for rehabilitation. Fourteen healthy young adults synchronised heel contact to an auditory metronome twice each in four conditions (uncued, white noise, pink noise, and red noise) and three sessions. FI differed based on the walking condition while no effect of session was revealed. The results of this study suggest gait fractality changes systematically with different stimuli and can be consistently prescribed in a desired direction within a group of healthy young individuals.     

The Opinions of GP's Patients About Suicide,Assisted Suicide,Euthanasia, and Suicide Prevention: An Italian Survey

A survey about opinions on end‐of‐life issues of a population represented by 1,171 people in the waiting room of general practitioners' surgeries was conducted in a province of northern Italy. Most subjects did not consider suicide as a reasonable option even in cases of a serious and incurable disease. Moreover, subjects did not consider euthanasia as a possible option either; however, they did express an opposite attitude when considering euthanasia in a third‐person perspective. People with a personal history of suicidal behavior appear to present as a different population, overall expressing more open attitudes.