Central executive function in mild cognitive impairment: a PET activation study

Using positron emission tomography (PET), we explored the neural correlates of an executive function, dual tasking, in patients with amnestic mild cognitive impairment (aMCI) and in elderly controls. The experiment employed simple auditory and visual tasks that were presented both in isolation and simultaneously to create a task condition requiring enhanced attentional control. Behaviorally, both groups performed well, albeit the patients made more errors on the visual task. The PET analysis focused at prefrontal regions where group differences in task-related activation patterns were expected. During dual task performance, the patients showed attenuated activity in the left inferior frontal region when compared to the controls. This suggests abnormalities in the neural processes underlying attentional control in aMCI.     

Effects of serotonin-mimetic drugs on mouse-killing behavior

Muricidal behavior induced in rats by social isolation or by olfactory bulb ablation was blocked following IP administration of serotonin (5–HT) agonist 8-OH-DPAT and 5-MeODM and by 5-HT uptake inhibitors, fluoxetine and indalpine. Among uptake inhibitors, although fluoxetine has a higher IC₅₀ and a higher Ki, it is apparently more efficient than indalpine. The 5-HT agonist, 8-OH-DPAT, acting at a putative 5-HT_1A receptor, appears more efficient on muricidal inhibition than 5-MeODM, at a much lower dosage. It is highly probable that 5-HT_1A receptor rather than 5-HT_1B is involved in the antimuricidal effect of serotonin-mimetic drugs. Since 5-HT mimetic drugs blocked mouse-killing behavior of bulbectomized rats, we suggest that in the sequence of events in muricidal inhibition 5-HT circuits participate after gabaergic modulation from olfactory bulbs.     

Dynamic presentation of magnified graphical characters on the IBM-compatible computers

Software that provides extremely smooth gliding and scrolling of magnified characters and pictograms on standard PCs is described. The program was designed as a tool for reading research, as a computer aid for visually impaired readers, and as a subtitle generator for multimedia applications. Change of font, size of characters, speed, color, and direction of movement can be made interactively. The system is useful for reading remediation and for creation of various visual effects.     

Teacher practices associated with students' sense of the classroom as a community

Data from observations of 232 elementary classrooms and from student questionnaires were used to test a model linking teacher classroom practices to students' sense of the classroom as a community (assessed by questionnaire) through intermediate effects on students' classroom behavior. The model was generally confirmed and showed that teacher practices (emphasis on prosocial values, elicitation of student thinking and expression of ideas, encouragement of cooperation, warmth and supportiveness, andreduced use of extrinsic control) were related to student classroom behaviors (engagement, influence, andpositive behavior), which, in turn, were related to students'sense of community. Teachers' encouragement of cooperative activities appeared to be particularly important in this sequence. The appropriateness of the model was tested for schools serving populations that were both high and low in level of poverty, and all estimates of path coefficients were found to be invariant across these groups.     

Return to Ithaca: A perspective on marriage and love in post traumatic stress disorder

This paper discusses the interactive effects of character development, love in marriage, and the stress pathology in the Vietnam War combatant. Over years of treating Vietnam veterans and their spouses, the authors have observed common patterns of interstructural or intercharacterological meshing between the Vietnam warrior and his wife. Implications for treatment are discussed along with useful intervention strategies.     

认知与情绪过程的脑诱发电位研究——情绪的适应性假说

本研究观测了30名女性被试在月经周期中的不同激素时相对图像刺激的情绪价值的主观评估和脑诱发电位反应。调节刺激的情绪价值的五类幻灯片分别为普通人像、婴儿像、皮肤病人像、男模特儿像和女模特儿像。实验发现只有脑诱发电位的P3成份随刺激的情绪价值和激素的时相而变化。被评为喜爱与不喜爱的图像(婴儿像和皮肤病人像)所诱发的P3波在幅度上均明显高于中性图像(普通人像)所致的P3反应。在高孕激素时相,对婴儿像和男模特儿像的P3反应高于在低孕激素时相对同类刺激的P3反应。高孕激素时相还伴有对各类图像性感程度评估值的降低。对各类图像喜爱程度的评估则随雌激素水平的上升而增高。上述实验结果表明,P3波敏感于刺激的情绪价值并反映了认知与情绪过程中受生理状态调节的适应性变化。     

Age-Related Personality Differences in Inpatients with Personality Disorder: A Cross-Sectional Study

There are few empirical studies of age-associated differences in personality characteristics of individuals diagnosed with Personality Disorder (PD), and none that comparatively examine multiple personality characteristics, with a variety of psychological measures, across a wide age range in adults diagnosed with PD and coexisting substance abuse. Personality test data of 392 psychiatric inpatients diagnosed with PD were analyzed by age group. Patients were assessed with the California Psychological Inventory, Psychological Inventory of Personality and Symptoms, Diagnostic Inventory of Personality and Symptoms, Minnesota Multiphasic Personality Inventory-1, and the Millon Clinical Multiaxial Inventory-1. There were no age differences in the number of patients diagnosed with PD, but older adults were significantly less likely to be diagnosed with more than one PD. Older patients with PD were significantly less impulsive, paranoid, high-energy, antisocial, and irresponsible than younger patients with PD. It appears that, with aging, there is a general mellowing of personality for those diagnosed with PD, which may be related to the proposed geriatric variants of PD.