Cognitive function, physical activity, and aging: possible biological links and implications for multimodal interventions

Increasing evidence shows the positive effect of physical activity (PA) on maintaining cognitive function. Both processes seem intrinsically linked to each other. The most likely mechanism is a reciprocal stimulation of neuroplasticity. Based on extensive experimental work on animals and humans, the concept of an enriched environment, including PA and challenging cognitive tasks, has provided the basis to systematically assess possible interventions for successful aging. I will use recent findings on brain mechanisms associated with PA and its effects on higher cognitive function at a systems and molecular level to demonstrate the need to design effective interventions. Such interventions should be designed to take advantage of the presumed compensatory mechanisms of elderly individuals, thereby limiting functional decline in higher cognitive performance in aging people. My review of the most recent relevant publications concerning this topic supports the notion that it is a promising approach to provide cognitive training and PA in conjunction, since the combination may generate synergistic beneficial changes than either one individually. Multimodal training programs should therefore be tested. However, at present there is insufficient evidence to conclude that multimodal interventions are superior to isolated cognitive or physical exercise interventions, since major studies addressing this topic are lacking. These studies are needed to conclusively prove that both strategies will positively interact when used in combined interventions. Finally the use of modern technology for these interventions will be discussed.     

The prevalence of loneliness among adults: a case study of the United Kingdom

Within contemporary Western (post) modern societies, loneliness is seen as a problem that is particularly associated with old age. Much less attention has been given to examining variations in loneliness across age groups. We examine patterns of loneliness across adults aged 15 years and older in the United Kingdom using data from the European Social Survey. We first consider the prevalence of loneliness among the adult population; then the relationship between loneliness and a range of key risk factors, and finally the relationship with age for each of our risk factors. Loneliness demonstrates a nonlinear U-shaped distribution, with those aged under 25 years and those aged over 65 years demonstrating the highest levels of loneliness. Depression is associated with loneliness for all age groups. Poor physical health is associated with loneliness in young adult and midlife but not later life. For those in mid and later life, the quality of social engagement is protective against loneliness, while for young adults it is the quantity of social engagement. This indicates that different factors may endow vulnerability (or protect) against loneliness at different stages of life and suggests that preventative strategies or interventions that reflect these variations need to be developed.     

In support of anti-intellectualism

Intellectualist theories attempt to assimilate know how to propositional knowledge and, in so doing, fail to properly explain the close relation know how bears to action. I develop here an anti-intellectualist theory that is warranted, I argue, because it best accounts for the difference between know how and mere “armchair knowledge.” Know how is a mental state characterized by a certain world-to-mind direction of fit (though it is non-motivational) and attendant functional role. It is essential of know how, but not propositional knowledge, that it makes possible performance errors and has the functional role of guiding action. The theory is attractive, in part, because it allows for propositional, non-propositional and perhaps even non-representational varieties of know how.     

Self-Imagery and Attentional Control Maintenance Factors of Social Anxiety: A Comparison of Trait and State Assessments

Journal of Psychopathology and Behavioral Assessment - Models of social anxiety (SA) posit that socially-evaluative fears may be maintained by biased cognitive processes such as attention and...     

‘Knowledge’ as a natural kind term

Naturalists who conceive of knowledge as a natural kind are led to treat ‘knowledge’ as a natural kind term. ‘Knowledge,’ then, must behave semantically in the ways that seem to support a direct reference theory for other natural kind terms. A direct reference theory for ‘knowledge,’ however, appears to leave open too many possibilities about the identity of knowledge. Intuitively, states of belief count as knowledge only if they meet epistemic criteria, not merely if they bear a causal/historical relation to the term. I will develop this objection and show that it is grounded in modal considerations central to Kripke’s work on reference. I will also argue that a more plausible externalist semantics for natural kind terms disarms the objection.     

Transmission arguments against knowledge closure are still fallacious

Transmission arguments against closure of knowledge base the case against closure on the premise that a necessary condition for knowledge is not closed. Warfield argues that this kind of argument is fallacious whereas Brueckner, Murphy and Yan try to rescue it. According to them, the transmission argument is no longer fallacious once an implicit assumption is made explicit. I defend Warfield’s objection by arguing that the various proposals for the unstated assumption either do not avoid the fallacy or turn the central premise of the transmission argument, namely that a necessary condition is not closed, into a redundant and superfluous premise. I conclude that Warfield’s advice is still to be heeded: Arguments against closure must not rely essentially on the premise that a necessary condition for knowledge is not closed.     

Immobility reaction at birth in newborn infant

Objective

To describe an immobility reaction (IR) that was not previously reported at or immediately after birth in human newborns.

Method

We analyzed 31 videos of normal term vaginal deliveries recorded from Time 0 of birth defined as the as the moment that lies between the birth of the thorax and the pelvis of the infant. We searched for perinatal factors associated with newborn's IR.

Results

IR at birth was observed in 8 of the 31 newborns. The main features of their behavior were immobilization, frozen face, shallow breathing and bradycardia. One of the 8 newborns had sudden collapse 2 h after birth. We found significant relationships between maternal prenatal stress (PS) and IR (p = .037), and a close to significant one between infants’ lividness at Time 0 and IR (p = .053). The first breath of the 31 newborns occurred before and was not associated with the first cry (p < .001).

Discussion

The main features of IR at birth are similar to those of the universal most severe response to severe stress or danger. The relationship with PS suggests that children who had IR at birth might be at risk for similar disorders as those associated with PS. Sudden neonatal collapse of one of the IR newborns needs further research to determine if they are at risk for sudden infant death syndrome.

Conclusion

This first report of an IR reaction at birth in human infants could open up new paths for improving early neonatal care. Further research is needed for maternal PS, stress hormones, umbilical cord blood pH measurements in IR newborns. The challenge of education and support for parents of IR newborns is outlined.     

Multifactor measurement of bodily feelings: Conceptual development,scale construction,and empirical validation

A series of studies is described demonstrating a coherent exploratory and confirmatory factor-analytic approach to the scaling of self-reported bodily feelings. This approach attempts to optimize the orthogonality, parsimony, and meaningfulness of a multifactor inventory. Psychometric properties of the resulting 35-item Bodily Feeling Scale (BFS) are presented and its comparability with other inventories is discussed. A validity study using item-content-based scales of the Minnesota Multiphasic Personality Inventory showed both concurrent and discriminative validity of the BFS. Implications for clinical and research utility are discussed.Portions of this research were conducted while the first author was supported by a University Graduate Fellowship awarded by the Graduate School of Arts and Sciences at Vanderbilt University.Professor Nunnally passed away in August 1982. His major contributions to the several stages of this research program are recognized through coauthorship.     

Naming consistency in Alzheimer''s disease

Although lexical semantic deficits are postulated to play a prominent role in the anomia of Alzheimer's disease, it is unclear whether the primary disturbance is one of lexical access or one of lexical semantic loss. Response consistency on a naming task is one means of evaluating the underlying source of naming impairment. Access dysfunction usually implies variable word-finding difficulty, while a theory of lexical loss predicts that many word names would be consistently unavailable. Nineteen Alzheimer's disease patients were administered a visual confrontation naming task (the Boston Naming Test) on two occasions 6 months apart. Eighty percent of errors occurred consistently at both times; only 20% of errors occurred on only one occasion. Response consistency occurred significantly more often than expected under the assumption of no response consistency. Findings support the hypothesis that anomia in Alzheimer's disease is in part due to a loss of lexical semantic information.