Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

The advantage of first mention in Spanish

An advantage of first mention—that is, faster access to participants mentioned first in a sentence—has previously been demonstrated only in English. We report three experiments demonstrating that the advantage of first mention occurs also in Spanish sentences, regardless of whether the first-mentioned participants are syntactic subjects, and regardless, too, of whether they are proper names or inanimate objects. Because greater word-order flexibility is allowed in Spanish than in English (e.g., nonpassive object-verb-subject constructions exist in Spanish), these findings provide additional evidence that the advantage of first mention is a general cognitive phenomenon.     

The visual perception of rigid motion from constant flow fields

Four experiments investigated observers’ judgments of rigidity for different types of optical motion. The depicted structural deformations were of two types: (1) those with nonparallel image trajectories that are detectable from the first-order spatiotemporal relations between pairs of views; and (2) those with parallel image trajectories that can only be detected from higher order relations among three or more views. Patterns were composed of smooth flow fields in Experiments 1 and 3, and of wire frame figures in Experiments 2 and 4. For both types of display, the nonrigidity detectable from the first-order spatiotemporal structure of the motion sequence was much more salient than the deformation detectable only from the higher order spatiotemporal structure. These results indicate that observers’ judgments of rigidity are based primarily on a two-view analysis, but that some useful information can be obtained under appropriate circumstances from higher order spatiotemporal relations among three or more views.     

Factor analysis of the social performance survey schedule

There are several studies suggesting that the Social Performance Survey Schedule (SPSS) is a reliable and valid measure of social skill. However, the factorial structure of the SPSS has never been examined. In the present study, SPSSs taken by 652 college students were factor analyzed by the method of principal components and the resulting factors were rotated according to the varimax criterion. Separate factor analyses were conducted for men and women. Seven factors, which accounted for a little over a third of the total variance, were retained for each sex. A large general factor labeled Prosocial Competence emerged for both sexes. Beyond this, the factorial solutions for the two sexes tended to diverge, with males showing a large negative factor (Social Offensiveness) and three smaller negative factors and females showing five relatively small negative factors. Suggestions were made concerning additional factor analytic studies of the SPSS and the ways in which derived factors might be used in research and clinical work.This research was supported by funds from the Rutgers University Research Council. Thanks are due to Leona Aiken for her statistical consultation.     

Experimental assessment of tinnitus aurium

A 32-year-old male volunteer with an eight year history of chronic unilateral tinnitus (ear-ringing) participated in a behavioral assessment strategy that included a series of measurement and modification procedures. A psychophysical matching technique was employed throughout a planned combination of procedures to assess and manipulate the intensity or loudness of tinnitus responses. Following baseline assessment, measurements were conducted at varying times of the day, concomitant with exposure to music, during progressive relaxation training, and under conditions of caffeine consumption. The value of careful assessment to describe cues and conditions associated with tinnitus and its reduction are discussed with implications for behavior treatment design and evaluation.     

Attending to different levels of structure in a visual image

Two experiments are reported in which observers had to utilize information from one of two structural levels of visual stimulus patterns (large letters composed of smaller ones). They could utilize information more rapidly form one level only at the cost of slower utilization from the other. This trade off defines an empirical attention operating characteristic (AOC) which is consistent with a simple mathematical model of the perceptual process: when viewing a stimulus, the observer selects one of two alternative “attentional” strategies, where each strategy is optimal for utilizing information from one structural level, but less than optimal for the other.     

The impact of social environment and sex on adolescent social values: A comparison of the kibbutz and the city in Israel

The present study compares the effects of two different socialization environments—the Israeli kibbutz and the city—on the social values held by 16-17 year-olds. A total of 352 boys and girls, 195 porn the city and 157 porn the kibbutz, filled out a specially prepared thirteen-item questionnaire on social values. The results revealed the existence of four factors underlying these values: self-oriented concerns (factor 1), other-oriented concerns (factor 2), reliance on innate spiritual capacities (factor 3), reliance on physical and productive capacities (factor 4). Significant differences on factors 1 and 3 were uncovered for the kibbutz and the city subjects, while boys and girls differed significantly on factors 2 and 4. The findings were discussed in light of the differences in educational systems between the kibbutz and the city, and in light of sex-role differences characteristic of Western society in general.     

Gender differences in autonomous and social achievement orientations

This research examined gender differences in orientations toward autonomous and social achievement. Three independent samples of subjects (total N= 359 males and 574 females) completed measures of achievement orientation (including Strumpfer's [1975] Autonomous Achievement Values and Social Achievement Values scales) and relevant cognitive, affective, and behavioral variables. Correlational and factor analyses clearly identified distinct autonomous and social achievement factors for both men and women in each of the samples. Examination of the correlates of achievement orientation indicated that whereas an autonomous achievement orientation is similarly expressed in males and females, there are considerable sex differences in the expression of an orientation toward social achievement. In particular, a social achievement orientation was associated with concerns over social approval and responsiveness to social influence among males, but was generally unrelated to these factors among females. Findings are discussed in terms of several recent hypotheses concerning the effects of sex role norms on the development and expression of achievement needs in men and women.     

The mirror of physics: on how the Price equation can unify evolutionary biology

Synthese - Due to its high degree of complexity and its historical nature, evolutionary biology has been traditionally portrayed as a messy science. According to the supporters of such a view,...