Interference with reelin signaling in the lateral entorhinal cortex impairs spatial memory

Entorhinal neurons receive extensive intracortical projections, and form the primary input to the hippocampus via the perforant pathway. The glutamatergic cells of origin for the perforant pathway are distinguished by their expression of reelin, a glycoprotein involved in learning and synaptic plasticity. The functional significance of reelin signaling within the entorhinal cortex, however, remains unexplored. To determine whether interrupting entorhinal reelin signaling might have consequences for learning and memory, we administered recombinant receptor-associated protein (RAP) into the lateral entorhinal cortex (LEC) of young Long-Evans rats. RAP prevents reelin from binding to its receptors, and we verified the knockdown of reelin signaling by quantifying the phosphorylation state of reelin’s intracellular signaling target, disabled-1 (DAB1). Effective knockdown of reelin signaling was associated with impaired performance in the hippocampus-dependent version of the water maze. Moreover, inhibition of reelin signaling induced a localized loss of synaptic marker expression in the LEC. These observations support a role for entorhinal reelin signaling in spatial learning, and suggest that an intact reelin signaling pathway is essential for synaptic integrity in the adult entorhinal cortex.     

Retrospective recall of sexual orientation identity development among gay, lesbian, and bisexual adults

Although recent attention has focused on the likelihood that contemporary sexual minority youth (i.e., gay, lesbian, bisexual [GLB]) are "coming out" at younger ages, few studies have examined whether early sexual orientation identity development is also present in older GLB cohorts. We analyzed retrospective data on the timing of sexual orientation milestones in a sample of sexual minorities drawn from the California Quality of Life Surveys. Latent profile analysis of 1,260 GLB adults, ages 18-84 years, identified 3 trajectories of development: early (n = 951; milestones spanning ages 12-20), middle (n = 239; milestones spanning ages 18-31), and late (n = 70; milestones spanning ages 32-43). Motivated by previous research on variability in adolescent developmental trajectories, we identified 2 subgroups in post hoc analyses of the early profile group: child onset (n = 284; milestones spanning ages 8-18) and teen onset (n = 667; milestones spanning ages 14-22). Nearly all patterns of development were identity centered, with average age of self-identification as GLB preceding average age of first same-sex sexual activity. Overall, younger participants and the majority of older participants were classified to the early profile, suggesting that early development is common regardless of age cohort. The additional gender differences observed in the onset and pace of sexual orientation identity development warrant future research.     

Sunk Cost and Commitment to Medical Treatment

The influence of prior, irretrievable, investment (sunk cost) on commitment to medical treatment was investigated. Three studies were run investigating the influence of sunk cost in the form of money, time, and effort. A total of 637 participants (314 male) with a mean age of 19.58 years were recruited from an undergraduate population. A computer program simulated the process of arranging a course of physiotherapy. Participants invested one of three amounts of sunk cost (under budget, on budget, or over budget) into arranging sessions with a chiropractor. Participants then decided how much time they wished to commit to these chiropractor sessions or to an alternative treatment with a better chance of success. Results revealed a significant effect of invested money, a significant effect of invested effort, but no effect of invested time. Invested money produced a sunk cost effect, while invested effort appeared to exert influence via cognitive dissonance. The implications for healthcare decision-making are discussed.     

What Accounts for Heterosexual Women’s Negative Emotional Responses to Lesbians?: Examination of Traditional Gender Role Beliefs and Sexual Prejudice

This study examined a pathway to heterosexual women’s experience of anger and anxiety in response to lesbian interactions. Participants were 149 18–30 year old heterosexual female undergraduates (56% African American) from a southeastern United States university. Participants completed measures of female gender role beliefs, sexual prejudice, and state affect, viewed a video depicting relationship behavior between a female–female or male–female dyad, and again completed a measure of state affect. Results indicated that traditional beliefs about women were associated with higher levels of sexual prejudice toward lesbians. In turn, higher levels of sexual prejudice predicted increased anger (not anxiety) in response to the female–female, but not the male–female, dyad. Findings elucidate determinants of heterosexual women’s anger, and potentially aggression, toward lesbians.     

Mothers' Parenting and Young Economically Disadvantaged Children's Relational and Overt Bullying

We examined links between mothers' parenting and children's relational bullying and overt bullying in a sample of children attending a Head Start program. Mothers completed surveys and face-to-face interviews. Head Start teachers completed assessments on children. Results indicated that a small percentage of children in the sample was rated by teachers as engaging in relational bullying “frequently to almost always,” and slightly over half of the sample was rated by teachers as engaging in relational bullying “occasionally to about half of the time.” Similar results were found for the frequency with which children engaged in overt physical bullying. Regarding mothers' parenting, maternal empathy was most strongly correlated with both children's relational bullying and overt physical bullying. In addition, mothers' inappropriate developmental expectations for children and mothers' need to exert power over children rather than grant them independence were related to children's relational bullying. A composite variable for mothering predicted 11% of the variance in children's relational bullying. No gender differences were found for children's relational bullying and children's overt bullying.     

Manipulating noise frequencies alters hemispheric contributions to decision making

Participants listened to the Asian disease problem framed in terms of either gains or losses and chose between two plans to combat the disease. All participants heard the problem embedded in other sounds; for some it was the relatively lower-frequency information, and for others it was the relatively higher-frequency information. The classic framing effect appeared only for those participants for whom the problem was the relatively lower-frequency information (p<.05). These results suggest that mixing filtered speech signals and noise may be a way to assess the role of the left and right hemisphere in various aspects of decision making.     

Children as Religious Resources: The Role of Children in the Social Re-Formation of Class, Culture, and Religious Identity

Based on observations and interviews in two churches representing two different strands of American Protestantism, I assess the ways in which children contribute to the social construction of class, culture, and religious identity for adults. Evidence comes from observing how congregations incorporate children into adult worship services and talk about them in texts and programs, and from the ways in which newer and long-term congregation members describe valuing and understanding children's ministries. These styles and their meanings reflect the history, heritage, and theological distinctives of these two strands of American Protestantism. Religion, I suggest, is not just good for children; children themselves are a religious resource whose presence in worship, service, and discourse helps to create and maintain a sense of identity, place, and meaning in the lives of worshipping adults.     

Successful Use of Peer Educators for Sharing Genetic Information

This study examined the impact of a genetics education module provided by Reach to Recovery peer volunteers. Participants included 113 women with confirmed breast cancer diagnoses. Eighty-eight of these women (78%) completed a baseline survey, participated in a peer-led intervention, and completed a follow-up survey. Approximately half of the women received an education module that included a genetic component, while the other half did not. Results indicated that women who received the genetics module had greater increases in genetics knowledge than the group that did not receive the module. However, follow-up interest in genetic testing was not significantly different between the two groups. Results indicate that a peer-led genetics module can increase knowledge about genetics. However, it does not appear to have a differential effect on genetic testing interest.