Social Function and Autism Spectrum Disorder in Children and Adults with Neurofibromatosis Type 1: a Systematic Review and Meta-Analysis

In light of the proliferation of recent research into social function in neurofibromatosis type 1 (NF1), a systematic review and meta-analysis is required to synthesise data and place findings within the context of a theoretical framework. This paper reviews findings from research into social function and autism spectrum disorder (ASD) in children and adults with NF1 and integrates these findings with the Socio-Cognitive Integration Abilities Model (SOCIAL). It also critically appraises links between social outcomes, internal and external factors moderating social functioning, cognitive domains implicated in social functioning, and underlying neural pathology in NF1. A systematic literature search conducted in MedLine (Ovid), PsycINFO (Ovid), Embase (Ovid), and PubMed electronic databases yielded 35 papers that met inclusion criteria for the systematic review. Out of these papers, 22 papers provided sufficient data for meta-analysis. Findings from this review and meta-analysis provide evidence that children and adults with NF1 exhibit significantly higher prevalence and severity of social dysfunction and ASD symptomatology. To date, very few studies have examined social cognition in NF1 but results indicate the presence of both perceptual and higher-level impairments in this population. The results of this review also provide support for age, gender, and comorbid ADHD as moderating factors for social outcomes in NF1. Suggestions for future research are offered to further our understanding of the social phenotype in NF1 and to facilitate the development of targeted interventions.     

ERPs reveal similar effects of social gaze orienting and voluntary attention, and distinguish each from reflexive attention

Spatial attention can be reflexively captured by a physically salient stimulus, effortfully directed toward a relevant location, or involuntarily oriented in the direction of another person's gaze (i.e., social gaze orienting). Here, we used event-related potentials to compare the effects of these three types of orienting on multiple stages of subsequent target processing. Although gaze orienting has been associated more strongly with reflexive capture than with voluntary attention, the present data provide new evidence that the neural effects of social gaze orienting are markedly different from the effects of reflexive attentional capture by physically salient stimuli. Specifically, despite their similar behavioral effects, social gaze orienting and reflexive capture produce different effects on both early sensory processing (~120 ms; P1/N1 components) and later, higher-order processing (~300 ms; P3 component). In contrast, the effects of social gaze orienting were highly similar to those of voluntary orienting at these stages of target processing.     

Perceptual categories and the computation of “grandmother”

Abstract

Recent theoretical approaches to understanding face recognition have used converging evidence from studies of normal face processing, everyday errors and patterns of neuropsychological impairment to suggest how different face processing modules are related to each other. This paper disuses four issues that arise from this body of work. These concern the nature of representations involved in face recognition, the existence of parallel pathways for processing different types of information, the relationship between recognition and awareness, and the question of how faces become familiar. Current research provoked by these issues is reviewed in the paper and suggestions are made about the ways in which such research will help refine theories of face processing.     

Recovery and predictors of language skills two years following pediatric traumatic brain injury

Subtle language processing difficulties may adversely affect scholastic performance, as well as communication and social skills. It is therefore crucial that language skills are monitored following traumatic brain injury (TBI) in childhood. The present study examined language skills in a group of 68 children who had sustained a mild, moderate or severe TBI. Results indicated that during the acute stage a dose-response relationship was evident, where severe TBI was associated with poorest performance and mild TBI with least deficits. By 24 months post-TBI, it was clear that for some language functions, the severe TBI group showed substantial recovery, and at times performed better than the moderate TBI group. Predictors of language and literacy skills at 24 months post TBI included pre-injury communication skills, socio-economic status, age at injury, and Vocabulary, as measured by the Wechsler Intelligence Scale for Children (WISC-111).     

TRAINING AND GENERALIZATION OF SEXUAL ABUSE PREVENTION SKILLS FOR WOMEN WITH MENTAL RETARDATION

Previous research has shown that behavioral skills training to teach sexual abuse prevention skills to women with mental retardation results in skill acquisition but poor generalization. In this investigation we evaluated procedures for enhancing generalization following training. Five women with mental retardation received 10 behavioral skills training sessions followed by in situ training when the skills did not fully generalize. Behavioral skills training resulted in skill acquisition and in situ training produced generalized responding during naturalistic assessments.     

Ambiguity seeking in multi-attribute decisions: Effects of optimism and message framing

This paper investigates the influence of message framing and personality variables on preferences over ambiguity in the context of multi-attribute decision scenarios. Undergraduate subjects responded to scenarios in which one of two medical treatments was associated with ambiguous probabilities of treatment effects. Probabilities were either positively or negatively framed. Subjects indicated their degree of preference for one treatment over the other. Subjects' optimism, trait anxiety, health locus of control, need for cognitive structure, and current mood were measured. In two separate studies, subjects preferred ambiguity when probabilities were positively framed, and were neutral toward ambiguity when probabilities were negatively framed. Also, in both studies the preference for ambiguity in positively framed scenarios was greater for more optimistic subjects. The unexpected finding of ambiguity seeking may be associated with the use of different decision strategies in multi-attribute versus single-attribute decisions.     

Perceived social structure,role, and communication patterns in an organization

Relationships among organizational roles, perceptions of the structure of the organization, and communications were studied in a university psychology department. Fifty-five members, representing five status groups (e.g., faculty, graduate students, etc.) and four sections of the department (e.g., Counseling, Experimental, etc.), judged the similarity of 16 faculty stimuli, rated the faculty on their interests and activities, and reported on their own communications. Individual Differences Multidimensional Scaling analysis of the similarities data revealed four dimensions of the perceptions of the organization: Section Affiliation, Teaching versus Research, Interest in Industrial Psychology, and Orthodoxy of Life-Style. Section groups differed significantly both in their communications and in the way the Orthodoxy of Life-Style dimension was weighted in their perceptions of the organization. Perceptions of the organization were related to communication behavior.