The clinical overlap between the corticobasal degeneration syndrome and other diseases of the frontotemporal spectrum: three case reports

The corticobasal degeneration syndrome has been suggested to be part of a complex of conditions (including the different subtypes of frontotemporal dementia and progressive supranuclear palsy), which reflect a spectrum of pathological substrates. This concept is supported by the frequent clinical overlap that can be observed among patients diagnosed with these conditions. We report three clinical cases, characterized by the overlap of the clinical features of corticobasal degeneration syndrome with, respectively, nonfluent progressive aphasia, progressive supranuclear palsy and semantic dementia. Current diagnostic criteria emphasize differences in clinical presentation, which probably reflect the preferential location of pathology in the early stages of disease. However, with disease progression, a considerable clinical overlap can be expected among the different syndromes. This concept should be extended not only to the cognitive and behavioural features of the frontotemporal dementia subtypes, but also to the movement disorders of corticobasal degeneration and supranuclear palsy.     

Switching between goals mediates the attentional blink effect

Humans are fundamentally limited in processing information from the outside world. This is particularly evident in the attentional blink (AB), the impaired ability to identify the second of two targets presented in close succession. We report findings from three experiments showing that the AB is significantly reduced when observers are set to achieve one single goal (reporting combinations of the two targets) instead of separate goals (reporting the two targets). This finding raises questions about the nature of AB, and suggests that processes involved in goal-switching must be taken into account by theories of the AB phenomenon.     

Facilitation and inhibition caused by the orienting of attention in propositional reasoning tasks

In an attempt to study the orienting of attention in reasoning, we developed a set of propositional reasoning tasks structurally similar to Posner's (1980) spatial cueing paradigm, widely used to study the orienting of attention in perceptual tasks. We cued the representation in working memory of a reasoning premise, observing whether inferences drawn using that premise or a different, uncued one were facilitated, hindered, or unaffected. The results of Experiments 1a, 1b, 1c, and 1d, using semantically (1a-1c) or statistically (1d) informative cues, showed a robust, long-lasting facilitation for drawing inferences from the cued rule. In Experiment 2, using uninformative cues, inferences from the cued rule were facilitated with a short stimulus onset asynchrony (SOA), whereas they were delayed when the SOA was longer, an effect that is similar to the “inhibition of return” (IOR) in perceptual tasks. Experiment 3 used uninformative cues, three different SOAs, and inferential rules with disjunctive antecedents, replicating the IOR-like effect with the long SOAs and, at the short SOA, finding evidence of a gradient-like behaviour of the facilitation effect. Our findings show qualitative similarities to some effects typically observed in the orienting of visual attention, although the tasks did not involve spatial orienting.     

Bilingual aphasia and language control: A follow-up fMRI and intrinsic connectivity study

In a world that is becoming more multilingual, bilingual aphasia is a clinical problem with a major clinical impact. However, at present we lack causal explanations of the many features of recovery patterns and there is no consensus about the language in which the patient should receive speech therapy. Further advance requires an understanding of the dynamics of recovery. In a novel longitudinal, single-case study, we combine fMRI and dynamic causal modeling to examine the effects of specific language treatment for picture naming on the representation and control of language areas during the course of recovery. Improved performance in the treated language was associated with increased activation in language areas. Consistent with theoretical expectations, causal modeling indicated increased connectedness of the control and language networks for the treated language. This functional approach holds great promise for investigating recovery patterns and the effects of specific language treatment in bilingual aphasic patients.     

Minority Influence,Social Change,and Social Stability

From Moscovici (Social influence and social change. London, Academic Press; 1976) on, a growing body of research on minority influence has been conducted within the social psychology mainstream. A general guideline of most of the research on this topic associates minority influence with social change and innovation. Minorities have been considered as challengers to social stability, and their dynamics have been considered in relation to the mechanisms through which social changes occur and established norms are modified and evolve in human society. In the present paper, we try to extend this viewpoint by suggesting that it represents only one side of a much more complex story. We consider the conditions under which minorities produce social change as well as the conditions under which they are, instead, inclined to defend the status quo. We then suggest that an integrative account of different approaches – namely, social identity, social dominance, and system justification – might contribute to expanding the theoretical frame of minority influence.     

Bare-Boned Demonstratives

This essay proposes a novel semantic account of demonstratives, aimed at clarifying the sense in which demonstratives are semantically dependent on demonstrations. Its first two sections summarize the main views currently on the market. Section 3 argues that they are all vitiated by the same shortcomings, and yield incorrect results of ‘truth in virtue of character’ and entailment. Section 4 proposes a different account of the relationships between demonstratives and demonstrations, grounded on the idea of truth-conditionally irrelevant aspects of the meaning of certain expressions. The resulting view of demonstratives is consonant with the so-called ‘bare boned’ account of their truth-conditional role, but is also in the position to recognize that the dependence of a demonstrative on a demonstration is, in some sense of the term, meaning-governed. The final section of this essay discusses the distinction between ‘vacuous’ and ‘incomplete’ uses of demonstratives, and cases involving multiple occurrences of these expressions.     

Indexicality, intensionality, and relativist post-semantics

This essay argues that relativist semantics provide fruitful frameworks for the study of the relationships between meaning and truth-conditions, and consequently for the analysis of the logical properties of expressions. After a discussion of the role of intensionality and indexicality within classic double-indexed semantics, I explain that the non-relativistic identification of the parameters needed for the definition of truth and for the interpretation of indexicals is grounded on considerations that are irrelevant for the assessment of the relationships between meaning and truth.     

Gaze and eye-tracking solutions for psychological research

Eye-tracking technology is a growing field used to detect eye movements and analyze human processing of visual information for interactive and diagnostic applications. Different domains in scientific research such as neuroscience, experimental psychology, computer science and human factors can benefit from eye-tracking methods and techniques to unobtrusively investigate the quantitative evidence underlying visual processes. In order to meet the experimental requirements concerning the variety of application fields, different gaze- and eye-tracking solutions using high-speed cameras are being developed (e.g., eye-tracking glasses, head-mounted or desk-mounted systems), which are also compatible with other analysis devices such as magnetic resonance imaging. This work presents an overview of the main application fields of eye-tracking methodology in psychological research. In particular, two innovative solutions will be shown: (1) the SMI RED-M eye-tracker, a high performance portable remote eye-tracker suitable for different settings, that requires maximum mobility and flexibility; (2) a wearable mobile gaze-tracking device--the SMI eye-tracking glasses--which is suitable for real-world and virtual environment research. For each kind of technology, the functions and different possibilities of application in experimental psychology will be described by focusing on some examples of experimental tasks (i.e., visual search, reading, natural tasks, scene viewing and other information processing) and theoretical approaches (e.g., embodied cognition).