Using latent class growth analysis to form trajectories of premorbid adjustment in schizophrenia

Premorbid adjustment varies widely among individuals with schizophrenia and has been shown to bear significantly on prodrome and onset characteristics, and on cognition, symptoms, and functioning after onset. The current analysis focused on the Premorbid Adjustment Scale, a retrospective measure assessing social and academic function at several time points from early childhood to illness onset. In an effort to explore discrete developmental subtypes, we applied latent class growth analysis to data from the Premorbid Adjustment Scale in our sample of individuals with schizophrenia (N = 208), finding three latent trajectory classes. The first of these classes showed consistently adequate-to-good social and academic functioning before onset; the second showed initially good function and deterioration with time until onset; the third showed poor functioning in childhood that deteriorated further during the years up to diagnosis. The classes differed significantly in terms of age of onset, processing speed, and functioning after onset. There were no significant differences in symptomatology. Our findings illustrate a potentially powerful methodological approach to the problem of heterogeneity in schizophrenia research, and add weight to the notion that aspects of premorbid history may be useful for subtyping schizophrenia patients. The potential implications of this subtyping strategy, including those pertaining to potential genetics studies, are discussed.     

Supporting Integrity of Discrete Trial Teaching via Tiered Consultation: A Pilot Study

Empirically supported consultation procedures for supporting implementation of evidence-based interventions for Autism Spectrum Disorder (ASD), such as performance feedback, may be challenging to implement in public schools. Educators may find performance feedback aversive, and support personnel may find its directiveness incompatible with their professional roles. This pilot study extends recent advances in implementation science, by investigating the influence of tiered consultation on intervention integrity of Discrete Trial Teaching (DTT). A less intensive form of implementation support was examined for its feasibility and effectiveness. Collaborative Student Data Review (CSDR) includes discussion, general feedback, and modeling. Preliminary findings indicate that CSDR is a feasible and acceptable form of implementation support, and that it shows potential as a form of implementation support for DTT.     

Estimated Risk of Developing Selected DSM-IV Disorders Among 5-Year-Old Children with Prenatal Cocaine Exposure

We estimated childhood risk of developing selected DSM-IV Disorders, including Attention-Deficit Hyperactivity Disorder (ADHD), Oppositional Defiant Disorder (ODD), and Separation Anxiety Disorder (SAD), in children with prenatal cocaine exposure (PCE). Children were enrolled prospectively at birth (n = 476) with prenatal drug exposures documented by maternal interview, urine and meconium assays. Study participants included 400 African-American children from the birth cohort, 208 cocaine-exposed (CE) and 192 non-cocaine-exposed (NCE), who attended a 5-year follow-up assessment and whose caregiver completed the Computerized Diagnostic Interview Schedule for Children. Under a generalized linear model (logistic link), Fisher’s exact methods were used to estimate the PCE-associated relative risk (RR) of these disorders. Our results indicated a modest but statistically robust elevation of ADHD risk associated with increasing levels of PCE (p < 0.05). Binary comparison of CE versus NCE children indicated no PCE-associated RR. Estimated cumulative incidence proportions among CE children were 2.9% for ADHD (vs 3.1% NCE); 1.4% for SAD (vs 1.6% NCE); and 4.3% for ODD (vs 6.8% NCE). Our findings suggest evidence of increased risk of ADHD (but not ODD or SAD) in relation to an increasing gradient of PCE during gestation.     

Information-Seeking Practices during the Sexual Development of Lesbian, Gay, and Bisexual Individuals: The Influence and Effects of Coming Out in a Mediated Environment

Constructing a sexual identity is one of the major developmental tasks of adolescence. Applying the Media Practice Model, this study retrospectively examines how self-identifying lesbian, gay, and bisexual (LGB) individuals used media during the commencement of the coming-out process and the effects of media use during this pivotal time of development. Results indicate that the Internet plays a critical role in the development of LGB sexual identities. Heavy users of media during the coming-out process are significantly less likely to communicate openly with their families later in life. However, individuals’ reports of loneliness and self-esteem are not affected. Conclusions suggest that mediated forms of communication can be beneficial for sexual exploration among LGB individuals.     

Type of stimulus mediates the relationship between working-memory performance and type of precocity

The relationship between type of stimulus (numeric and verbal) and type of precocity (mathematical and verbal) was examined in tasks designed to tap three aspects of working memory: encoding, capacity, and manipulation of information. The tasks included semantic categorization, odd-even categorization, recall of five-item lists after semantic categorization, and recall of items in a continuous paired-associates task. Correlations between task performance and the mathematical and verbal portions of the Scholastic Aptitude Test (SAT-M and SAT-V) were computed for gifted youth. There were no sex differences in the performance measures or in the pattern of correlations between performance and SAT scores. The analysis revealed positive relationships between SAT-M scores and numeric categorization latency, recall in the continuous paired-associate task with words and digits, and recall of digit lists. SAT-V scores were related only to word recall in the continuous paired-associate task and recall of word lists. In the working-memory tasks used, mathematical precocity is more strongly related to performance than is verbal precocity. The relationship is especially strong with numeric stimuli, even when the numeric stimuli are simply items to be remembered. The relationship between type of stimulus and type of precocity suggests underlying differences between verbally and mathematically precocious youth in how different types of stimuli are represented in memory.     

Semantic priming,prime reportability,and retroactive priming are interdependent

In two experiments, semantic analysis of prime words was measured in terms of facilitation in naming a semantically related target word. Targets were degraded but gradually clarified until the subject named them. Subjects reported the prime after naming the target. Experiment 1 used semantic associates as primes at a 50-msec prime-target stimulus onset asynchrony (SOA). Experiment 2 used both semantic-associate and identity primes at a 1,000-msec prime-target SOA. Reported primes showed facilitation in both experiments, whereas unreported primes did not. It appears that primes that undergo enough analysis to facilitate target processing are also available for conscious report. However, retroactive priming in both experiments showed that target processing also had an impact on prime reportability. The interdependence of priming and prime reportability disallows a straightforward interpretation of the origin of the facilitation.     

Word and picture identification: Is representational parsimony possible?

Four experiments were conducted to evaluate the proposition that although prior exposure to a printed word facilitates identification of a corresponding picture, exposure to a picture does not facilitate subsequent word recognition (Durso & Johnson, 1979). Word identification was used, rather than naming latency, in order to avoid the range limitations in adult reading data. Word identification was facilitated by intermodal priming (prior exposure to a corresponding picture), although to a lesser extent than by intramodal (i.e., word-word) priming; the magnitude of intermodal priming was insensitive to strategy; and, as with priming from spoken to printed language, the major impact of word frequency occurred under intermodal, as distinct from intramodal, conditions. Following Scarborough, Gerard, and Cortese (1979), a fifth experiment compared word identification and episodic recognition. Intramodal performance was superior in word identification, whereas intermodal (i.e. picture-word) performance was superior in episodic recognition, a reversal which suggests that episodic recognition involves access to a distinct memory trace.     

Interventions to Address the Academic Impairment of Children and Adolescents with ADHD

There exists a strong link between ADHD and academic underachievement. Both the core behavioral symptoms of ADHD and associated executive functioning deficits likely contribute to academic impairment. Current evidence-based approaches to the treatment of ADHD (i.e., stimulant medication, clinical behavior therapy and classroom behavioral interventions) have demonstrated a robust impact on behavioral variables such as attention and disruptive behavior within classroom analogue settings; however, their efficacy in improving academic outcomes is much less clear. Although surprisingly few treatment outcome studies of ADHD have attempted to incorporate interventions that specifically target academic outcomes, the studies that are available suggest that these interventions may be beneficial. The state of the treatment literature for addressing academic impairment in children and adolescents with ADHD will be reviewed herein, as well as limitations of current research, and directions for future research.     

Crossmodal object-based attention: auditory objects affect visual processing

According to the object-based view, visual attention can be deployed to "objects" or perceptual units, regardless of spatial locations. Recently, however, the notion of object has also been extended to the auditory domain, with some authors suggesting possible interactions between visual and auditory objects. Here we show that task-irrelevant auditory objects may affect the deployment of visual attention, providing evidence that crossmodal links can also occur at an object-based level. Hence, in addition to the well documented control of visual objects over what we hear, our findings demonstrate that, in some cases, auditory objects can affect visual processing.