Assessment of apathy in neurological patients using the Apathy Motivation Index caregiver version

Apathy is a common, disabling neuropsychiatric syndrome that occurs across many brain disorders and may be associated with diminished motivation in behavioural, cognitive, emotional and social domains. Assessment is complicated by the variability of symptoms across apathy domains and self-report from patients, which can be misleading due to their lack of insight. Independent evaluation by clinicians also has limitations though if it has to be performed with limited time. Caregiver reports are a viable alternative, but current assessments for them either do not distinguish between different apathy domains or are interview-based and take long to administer. In this study, we developed a brief caregiver questionnaire version of the recently developed Apathy Motivation Index (AMI), which is a self-report tool. We confirmed three apathy factors in this new caregiver measure (AMI-CG) that were also present in the AMI: Behavioural Activation, Emotional Sensitivity and Social Motivation. Furthermore, we validated the scores against more extensive caregiver interviews using the established Lillle apathy rating scale as well as patient self-reports of apathy, measures of depression, anhedonia, cognition, activities of daily living and caregiver burden across four different neurological conditions: Parkinson's disease, Alzheimer's disease, subjective cognitive impairment and limbic encephalitis. The AMI-CG showed good internal reliability, external validity and diagnostic accuracy. It also uncovered cases of social apathy overlooked by traditional instruments. Crucially, patients who under-rated their apathy compared to informants were more likely to have difficulties performing everyday activities and to be a greater burden to caregivers. The findings provide evidence for a multidimensional conceptualization of apathy and an instrument for efficient detection of apathy based on caregiver reports for use in clinical practice.     

With the past behind and the future ahead: Back-to-front representation of past and future sentences

Several studies support the psychological reality of a mental timeline that runs from the left to the right and may strongly affect our thinking about time. Ulrich and Maienborn (Cognition 117:126–138, 2010) examined the linguistic relevance of this timeline during the processing of past- and future-related sentences. Their results indicate that the timeline is not activated automatically during sentence comprehension. While no explicit reference of temporal expressions to the left–right axis has been attested (e.g., *the meeting was moved to the left), natural languages refer to the back–front axis in order to encode temporal information (e.g., the meeting was moved forward). Therefore, the present study examines whether a back–frontal timeline becomes automatically activated during the processing of past- and future-related sentences. The results demonstrate a clear effect on reaction time that emerges from a time–space association along the frontal timeline (Experiment 1). However, this activation seems to be nonautomatic (Experiment 2), rendering it unlikely that this frontal timeline is involved in comprehension of the temporal content of sentences.     

Interactions between apparent motion rivalry in vision and touch

In multistable perception, the brain alternates between several perceptual explanations of ambiguous sensory signals. It is unknown whether multistable processes can interact across the senses. In the study reported here, we presented subjects with unisensory (visual or tactile), spatially congruent visuotactile, and spatially incongruent visuotactile apparent motion quartets. Congruent stimulation induced pronounced visuotactile interactions, as indicated by increased dominance times for both vision and touch, and an increased percentage bias for the percept already dominant under unisensory stimulation. Thus, the joint evidence from vision and touch stabilizes the more likely perceptual interpretation and thereby decelerates the rivalry dynamics. Yet the temporal dynamics depended also on subjects' attentional focus and was generally slower for tactile than for visual reports. Our results support Bayesian approaches to perceptual inference, in which the probability of a perceptual interpretation is determined by combining visual, tactile, or visuotactile evidence with modality-specific priors that depend on subjects' attentional focus. Critically, the specificity of visuotactile interactions for spatially congruent stimulation indicates multisensory rather than cognitive-bias mechanisms.     

Long-term adherence to a physical activity intervention: The role of telephone-assisted vs. self-administered coping plans and strategy use

Objective: This study investigated the role of coping plans and the use of selection, optimisation and compensation (SOC) strategies within an experimental evaluation of a 26-week physical exercise intervention.

Methods: Older women (N?=?86, M _age?=?73.7 years) were randomly assigned to a telephone-assisted or a self-administered coping planning intervention after 6 weeks’ participation in an exercise programme. The number of different coping plans formulated, exercise-specific SOC strategy use and their interaction were used to predict objectively measured long-term adherence to the intervention.

Results: The number of coping plans formulated (β?=?0.28) and goal-pursuit strategies reported (sum score of optimisation and compensation strategies, β?=?0.39) predicted adherence to the exercise programme over 20 weeks. The predictive strength of coping plans increased with decreasing numbers of goal-pursuit strategies (β?=??0.21). Women supported via telephone reported significantly more coping plans than did women in the self-administered coping planning group, F(1,80)?=?9.47, p?=?0.003.

Conclusion: Coping plans have a buffering effect on adherence levels when use of SOC strategies is low. Older women's adherence to physical activities may be improved if they are given direct support in generating coping plans involving strategies of selection, optimisation and compensation.     

Classic Stroop Negative Priming effects for children and adults diverge with less-conflicting and nonconflicting conditions

Negative priming indexes an inhibition process that aids target selection by reducing distractor interference. To date, children have produced negative priming only in tasks where distractor response tendencies are consistently greater than or equal to targets and not in tasks containing a substantial proportion of low-conflict distractors. To establish the exact parameters under which children's negative priming attenuates relative to adults, we varied processing demands across 2 experiments involving children and adults. Negative priming was comparable when 100% high-conflict conditions were encountered (Experiment 1) and was intact in adults but not children when a ratio of 50:50 high- to low-conflict conditions was encountered (Experiment 2). Compared with adults, children seem induced to divide attention more generally when low-conflict attentional conditions are included, attenuating negative priming.     

My role is my castle — The appeal of family roles after experiencing social exclusion

The present research investigated whether perceived social exclusion would lead women to embrace the social group of the family (and its traditional gender roles). In two studies, it was found that in comparison to a social inclusion manipulation, a social exclusion manipulation caused women to report significantly more positive inclinations towards traditional, gendered work allocations (Studies 1 and 2). Moreover, seeking meaning in life mediated the relationship between social exclusion and the perceived attractiveness of the roles of mother and housewife (Study 2). In a third study, adherence to family-related concepts was examined in both socially excluded and included men, but no difference was found between the two groups. It thus appears that social exclusion does not enhance the attractiveness of familial relationships for men. The theoretical and practical implications of these findings are discussed.     

The Euclidean model of measurement in Fechner's psychophysics

Historians acknowledge Euclid and Fechner, respectively, as the founders of classical geometry and classical psychophysics. At all times, their ideas have been reference points and have shared the same destiny of being criticized, corrected, and even radically rejected, in their theoretical and methodological aspects and in their epistemological value. According to a model of measurement of magnitudes which goes back to Euclid, Fechner (1860) developed a theory for psychical magnitudes that opened a lively debate among numerous scholars. Fechner's attempt to apply the model proposed by Euclid to subjective sensation magnitudes--and the debate that followed--generated ideas and concepts that were destined to have rich developments in the psychological and (more generally) scientific field of the twentieth century and that still animate current psychophysics.     

Relative influences of lightness and facial morphology on perceived race

In a recent study (Brooks and Gwinn, 2010 Perception 39 1142-1145), the lightness contrast illusion was employed to study the influences of skin tone and facial morphology on race perception. The findings were rather counterintuitive: they suggested that skin tone does not play a major role in racial categorisation. To investigate this further, we used a parametric paradigm including five lightness levels, five morphing levels, and two face orientations. In accordance with Brooks and Gwinn, we found that race categorisation of African-American and Caucasian faces by Caucasian participants relied mainly on morphological cues. However, the relative influence of lightness increased when morphological information was ambiguous and when the faces were upside down. Overall, the results point to a flexible multicue-based mechanism underlying race perception.     

What the eyes already ‘know’: using eye movement measurement to tap into children's implicit numerical magnitude representations

To date, a number of studies have demonstrated the existence of mismatches between children's implicit and explicit knowledge at certain points in development that become manifest by their gestures and gaze orientation in different problem solving contexts. Stimulated by this research, we used eye movement measurement to investigate the development of basic knowledge about numerical magnitude in primary school children. Sixty‐six children from grades one to three (i.e. 6–9 years) were presented with two parallel versions of a number line estimation task of which one was restricted to behavioural measures, whereas the other included the recording of eye movement data. The results of the eye movement experiment indicate a quantitative increase as well as a qualitative change in children's implicit knowledge about numerical magnitudes in this age group that precedes the overt, that is, behavioural, demonstration of explicit numerical knowledge. The finding that children's eye movements reveal substantially more about the presence of implicit precursors of later explicit knowledge in the numerical domain than classical approaches suggests further exploration of eye movement measurement as a potential early assessment tool of individual achievement levels in numerical processing. Copyright © 2009 John Wiley & Sons, Ltd.