One-year prediction of cognitive decline following cognitive-stimulation from real-world data

Clinical evidence based on real-world data (RWD) is accumulating exponentially providing larger sample sizes available, which demand novel methods to deal with the enhanced heterogeneity of the data. Here, we used RWD to assess the prediction of cognitive decline in a large heterogeneous sample of participants being enrolled with cognitive stimulation, a phenomenon that is of great interest to clinicians but that is riddled with difficulties and limitations. More precisely, from a multitude of neuropsychological Training Materials (TMs), we asked whether was possible to accurately predict an individual's cognitive decline one year after being tested. In particular, we performed longitudinal modelling of the scores obtained from 215 different tests, grouped into 29 cognitive domains, a total of 124,610 instances from 7902 participants (40% male, 46% female, 14% not indicated), each performing an average of 16 tests. Employing a machine learning approach based on ROC analysis and cross-validation techniques to overcome overfitting, we show that different TMs belonging to several cognitive domains can accurately predict cognitive decline, while other domains perform poorly, suggesting that the ability to predict decline one year later is not specific to any particular domain, but is rather widely distributed across domains. Moreover, when addressing the same problem between individuals with a common diagnosed label, we found that some domains had more accurate classification for conditions such as Parkinson's disease and Down syndrome, whereas they are less accurate for Alzheimer's disease or multiple sclerosis. Future research should combine similar approaches to ours with standard neuropsychological measurements to enhance interpretability and the possibility of generalizing across different cohorts.     

Behavioral profile of amisulpride in agonistic encounters between male mice

Amisulpride is a substituted benzamide derivative that acts as a selective dopamine D2/D3 receptor antagonist. Although the anti‐aggressive properties of neuroleptic drugs are well known, the effects of amisulpride on agonistic interactions have not been explored, and there are no studies comparing acute and subchronic effects of this compound on aggression in rodents. In this study, we examined the action of amisulpride (5–25 mg/kg, i.p), administered acutely or subchronically for 10 days, on agonistic behavior elicited by isolation in male mice. Individually housed mice were exposed to anosmic "standard opponents" 30 min after drug administration, and the encounters were videotaped and evaluated using an ethologically based analysis. After acute treatment, amisulpride (5–20 mg/kg) exhibited an ethopharmacological profile characterized by a marked decrease of offensive behaviors (threat and attack) without an impairment of motor activity. By contrast, the anti‐aggressive action of the highest dose used (25 mg/kg) was accompanied by a weak increase of immobility. Body care was also significantly enhanced after treatment with the drug (20 and 25 mg/kg), emphasizing the involvement of dopaminergic receptors in this behavior. After subchronic treatment, no tolerance to amisulpride anti‐aggressive activity was observed. Overall, this behavioral profile is similar to that observed by other atypical neuroleptics. Aggr. Behav. 25:225–232, 1999. © 1999 Wiley‐Liss, Inc.     

The use of partial information on weights in multicriteria decision problems

This paper addresses multicriteria decision problems in which only partial information is given in the decision-making process. We generalize existing results about preference relations induced by nonnegative inverse matrices, allowing linear relations on weights with upper and lower bounds. In addition we develop conditions for additional information that preserve the special properties studied and show how to incorporate the new information to the model. © 1998 John Wiley & Sons, Ltd.     

记忆与遗忘的社会建构

国家与市民社会的记忆《你们法国人记性短》(Fran ais,vous avez la m啨moire courte)是在圣苏比教堂对面的影院中上映的一个电影的片名。那是在20世纪60年代早期;第二次世界大战过去了几乎还不到15年,纳粹主义的恐怖尚未被完全揭露出来。德国是一个被占领和被分裂的国家。法国     

Is There A Simple,Pedestrian Arithmetic Sentence Which Is Independent Of Zfc?

We show that the P < NP conjecture can beformulated as a Pi₂ ⁰ sentence, and explore some of theconsequences of that fact. This paper summarizes recent workby the author with N. C. A. da Costa on the P相似文献   

How Preschoolers Associate Power with Gender in Male-Female Interactions: A Cross-Cultural Investigation

Sex Roles - Interactions between males and females often display a power imbalance. Men tend to adopt more dominant physical postures, lead conversations more, and are more likely to impose their...     

A consciousness-based quantum objective collapse model

Ever since the early days of quantum mechanics it has been suggested that consciousness could be linked to the collapse of the wave function. However, no detailed account of such an interplay is usually provided. In this paper we present an objective collapse model (a variation of the Continuous Spontaneous Location model) where the collapse operator depends on integrated information, which has been argued to measure consciousness. By doing so, we construct an empirically adequate scheme in which superpositions of conscious states are dynamically suppressed. Unlike other proposals in which “consciousness causes the collapse of the wave function,” our model is fully consistent with a materialistic view of the world and does not require the postulation of entities suspicious of laying outside of the quantum realm.

     

Troubles with Theoretical Virtues: Resisting Theoretical Utility Arguments in Metaphysics

In this paper we examine theoretical utility arguments in metaphysics. While philosophers claim a procedural continuity with science when using such arguments, we argue that examining famous instances from the history of science expose their fundamental flaws. We find that arguments from theoretical utility invoke considerations that are not truth conducive and that justifications for claims that a theory possesses theoretical virtues often assume the truth of the theory such virtues are supposed to support. We conclude that theoretical utility arguments provide no epistemic grounds for metaphysical inquiry.     

Applying Community-Based Participatory Approaches to Addressing Health Disparities and Promoting Health Equity

This special issue highlights work that contributes to our understanding of health disparities and community-based participatory research (CBPR) approaches to promoting health equity across diverse populations and issues that matter to communities. We take on a global perspective, and thus, various efforts across international contexts are illustrated. Articles elucidate a variety of CBPR approaches designed to empower and build capacity among individuals and communities in order to seek changes at the level of community practices, programs, and systems. These articles span across diverse populations—children, youth, and families; adults and older adults; immigrants; refugees; Black people; Latinx people; Native Americans/Indigenous people, the Roma community; Muslim women, and women with disabilities—experiencing inequities of interest to community psychologists and other researchers and practitioners.