Disclosing individual genetic results to research participants

Investigators and institutional review boards should integrate plans about the appropriate disclosure of individual genetic results when designing research studies. The ethical principles of beneficence, respect, reciprocity, and justice provide justification for routinely offering certain results to research participants. We propose a result-evaluation approach that assesses the expected information and the context of the study in order to decide whether results should be offered. According to this approach, the analytic validity and the clinical utility of a specific result determine whether it should be offered routinely. Different results may therefore require different decisions even within the same study. We argue that the threshold of clinical utility for disclosing a result in a research study should be lower than the threshold used for clinical use of the same result. The personal meaning of a result provides additional criteria for evaluation. Finally, the context of the study allows for a more nuanced analysis by addressing the investigators' capabilities for appropriate disclosure, participants' alternative access to the result, and their relationship with the investigators. This analysis shows that the same result may require different decisions in different contexts.     

Łukasiewicz and Popper on Induction

We compare Jan ?ukasiewicz's and Karl Popper's views on induction. The English translation of the two ?ukasiewicz's papers is included in the Appendix.     

Privileged access

That everyone has some privileged access to some information is trivially true. The doctrine of privileged access is that I am the authority on all of my own experiences. Possibly this thesis was attacked by Wittgenstein (the thesis on the non‐existence of private languages). The thesis was refuted by Freud (I know your dreams better than you), Duhem (I know your methods of scientific discovery better than you), Malinowski (I know your customs and habits better than you), and perception theorists (I can make you see things which are not there and describe your perceptions better than you can). The significance of this rejected thesis is that it is the basis of sensationalism and thus of all inductivist and some conventionalist philosophy.