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141.
Animal models are considered essential in research ensuing elucidation of human disease processes and subsequently, testing of potential therapeutic strategies. This is especially true for neurodegenerative disorders, in which the first steps in pathogenesis are often not accessible in human patients. Alzheimer's disease is vastly becoming a major medical and socioeconomic problem in our aging society. Valid animal models for this uniquely human condition should exhibit histopathological, biochemical, cognitive, and behavioral alterations observed in Alzheimer's disease patients. Major progress has been made since the understanding of the genetic basis of Alzheimer's disease and the development and improvement of transgenic mouse models. All present Alzheimer's disease models developed are partial but nevertheless essential in further unraveling the nature and spatial and temporal development of the complex molecular pathology underlying this condition. One of the more recent transgenic attempts to model Alzheimer's disease is the APP23 transgenic mouse. This article describes the development and assessment of this human amyloid precursor protein overexpression model. We summarize histopathological and biochemical, cognitive and behavioral observations made in heterozygous APP23 mice, thereby emphasizing the model's contribution to clarification of neurodegenerative disease mechanisms. In addition, the first therapeutic interventions in the APP23 model are included. 相似文献
142.
Present optimization techniques in latent class analysis apply the expectation maximization algorithm or the Newton-Raphson
algorithm for optimizing the parameter values of a prespecified model. These techniques can be used to find maximum likelihood
estimates of the parameters, given the specified structure of the model, which is defined by the number of classes and, possibly,
fixation and equality constraints. The model structure is usually chosen on theoretical grounds. A large variety of structurally
different latent class models can be compared using goodness-of-fit indices of the chi-square family, Akaike’s information
criterion, the Bayesian information criterion, and various other statistics. However, finding the optimal structure for a
given goodness-of-fit index often requires a lengthy search in which all kinds of model structures are tested. Moreover, solutions
may depend on the choice of initial values for the parameters. This article presents a new method by which one can simultaneously
infer the model structure from the data and optimize the parameter values. The method consists of a genetic algorithm in which
any goodness-of-fit index can be used as a fitness criterion. In a number of test cases in which data sets from the literature
were used, it is shown that this method provides models that fit equally well as or better than the models suggested in the
original articles. 相似文献
143.
This study served to replicate and extend our previously obtained hierarchical model of the relationships among general anxiety vulnerabilities, specific anxiety vulnerabilities and specific anxiety manifestations including panic symptoms, health anxiety, obsessive-compulsive symptoms and worry. Questionnaires assessing these variables, as well as positive affectivity and depressiveness, were administered to 125 outpatients seeking treatment for panic disorder, social anxiety disorder, obsessive-compulsive disorder, generalized anxiety disorder or major depressive disorder. The results, using a clinical sample, were highly consistent with the hierarchical model obtained in the previous study using a student sample. A more elaborate model, based on published theoretical and empirical evidence, was identified and tested, and similar results were obtained. Negative affectivity had expected direct positive effects on all of the specific anxiety and depression manifestations, with the exception of health anxiety, which showed a negative relationship, and OCD symptoms, which showed no relationship. Positive affectivity was found to be a specific risk factor for depression, while intolerance of uncertainty was found to be a specific risk factor for worry and depression. Finally, anxiety sensitivity appears to be a significant risk factor for panic and health anxiety. 相似文献
144.
A blank look in reading: the effect of blank space on the identification of letters and words during reading 总被引:1,自引:0,他引:1
Two experiments investigated the effect of visual blank space on reading by varying the amount of interletter and interline blank space in prose passages. Increasing interletter blank spacing slowed the reading process overall, presumably because it disrupted the unitization of words and word identification, but it also improved the identification of the letters within words. By contrast, increasing interline blank spacing sped up the reading process overall, while also improving the identification of words and the letters within words, presumably because the extra spacing reduced the amount of visual information that was processed during reading. The latter finding supports the conclusion that information from surrounding lines of single-spaced text may interfere with reading. 相似文献
145.
Two studies examined the effect of status and liking of the anger target on anger behavior and individual differences in anger-related behavior. Participants recalled anger instances in which the anger target was of higher/equal/lower status and/or liked/ unfamiliar/disliked; subsequently, they indicated which behaviors they had displayed. In both studies, anger behaviors could be grouped into behaviors that imply approaching the target (anger-out, assertion, reconciliation) and behaviors that reflect avoidance/anger-in or social sharing. The results demonstrated that approach behaviors more likely occur toward lower status or liked targets; avoidance behaviors and social sharing more likely occur when the target is of higher status or disliked. On an individual differences level, an approach and an avoid/social sharing person class were identified. The findings suggest that anger may motivate prosocial behavior or social sharing, depending on the individual and type of relation with the target. Only few gender differences were found. 相似文献
146.
This study explored the effects of ageing on working memory by means of the directed forgetting procedure designed by Reed (1970). Memory for a letter trigram was compared in conditions where it was either presented alone (single-item), or followed by a second trigram to be recalled (interference), or followed by a second trigram to be forgotten (directed forgetting). The results clearly indicated that elderly participants inhibited the no-longer-relevant information less efficiently (recall in the single-item condition - recall in the directed forgetting condition), as predicted by the model of Hasher and Zacks (1988). However, the results also demonstrated that sensitivity to interference (recall in the single-item condition - recall in the interference condition) increased in the condition in which no inhibition was directly required. 相似文献
147.
148.
Lawler CP Croen LA Grether JK Van de Water J 《Mental retardation and developmental disabilities research reviews》2004,10(4):292-302
The potential role of environmental factors in autism spectrum disorders (ASD) is an area of emerging interest within the public and scientific communities. The high degree of heritability of ASD suggests that environmental influences are likely to operate through their interaction with genetic susceptibility during vulnerable periods of development. Evaluation of the plausibility of specific neurotoxicants as etiological agents in ASD should be guided by toxicological principles, including dose-effect dependency and pharmacokinetic parameters. Clinical and epidemiological investigations require the use of sufficiently powered study designs with appropriate control groups and unbiased case ascertainment and exposure assessment. Although much of the existing data that have been used to implicate environmental agents in ASD are limited by methodological shortcomings, a number of efforts are underway that will allow more rigorous evaluation of the role of environmental exposures in the etiology and/or phenotypic expression of the disorder. Surveillance systems are now in place that will provide reliable prevalence estimates going forward in time. Anticipated discoveries in genetics, brain pathology, and the molecular/cellular basis of functional impairment in ASD are likely to provide new opportunities to explore environmental aspects of this disorder. 相似文献
149.
150.
Koster EH Crombez G Van Damme S Verschuere B De Houwer J 《Emotion (Washington, D.C.)》2004,4(3):312-317
According to models of attention and emotion, threat captures and holds attention. In behavioral tasks, robust evidence has been found for attentional holding but not for attentional capture by threat. An important explanation for the absence of attentional capture effects is that the visual stimuli used posed no genuine threat. The present study investigated whether visual cues that signal an aversive white noise can elicit attentional capture and holding effects. Cues presented in an attentional task were simultaneously provided with a threat value through an aversive conditioning procedure. Response latencies showed that threatening cues captured and held attention. These results support recent views on attention to threat, proposing that imminent threat captures attention in everyone. 相似文献