Increased regional cerebral glucose metabolism and semantic memory performance in Alzheimer's disease: A pilot double blind transdermal nicotine positron emission tomography study

Nicotinic receptor dysfunction and impaired semantic memory occur early in Alzheimer's disease patients (AD). Previous research implied that nicotine's ability to enhance alertness, arousal, and cognition in a number of nonclinical populations was a function of its ability to stimulate CNS nicotinic cholinergic receptors. In this study it was hypothesized that transdermal administration of nicotine would increase both regional cerebral glucose metabolism (rCMRglc) and semantic memory (as assessed by verbal fluency). Two mild AD and two elderly controls underwent positron emission tomography scanning during a double blind nicotinic agonist verbal fluency challenge procedure. rCMRglc increases occurred in both AD patients, but not controls. In the two AD patients, verbal fluency scores increased by an average of 17%. One elderly control's verbal fluency increased, and the other decreased. These findings suggest that nicotine's effect on metabolism and verbal fluency is due to its ability to stimulate the cholinergic system.     

Applying Primary Prevention Precepts to Campus Substance Abuse Programs

The authors identify five primary prevention programming precepts dealing with perspective, targets, methods, intentionality, and ethic. They describe how the United States Department of Education's Fund for the Improvement of Post Secondary Education (FIPSE) sponsored University of Cincinnati substance abuse prevention project was developed by following these precepts. They hope that this information will aid others in their development of primary prevention programs in college substance abuse (i.e., alcohol and other drug abuse) or in other areas.     

FUZZY-TRACE THEORY AND FRAMING EFFECTS IN CHILDREN'S RISKY DECISION MAKING

Traditional theories of cognitive development predict that children progress from intuitive to computational thinking, whereas fuzzy-trace theory makes the opposite prediction To evaluate these alternatives, framing problems were administered to preschoolers, second graders, and fifth graders Consistent with fuzzy-trace theory, results indicated (a) that younger children focused on quantitative differences between outcomes and did not exhibit framing effects (risk avoidance for gains, risk seeking for losses) and (b) that older children assimilated these quantitative differences and displayed framing effects     

Individual differences in mental animation during mechanical reasoning

In three experiments we tested the effects of spatial visualization ability on performance of a motion-verification task, in which subjects were shown a diagram of a mechanical system and were asked to verify a sentence stating the motion of one of the system components. We propose that this task involves component processes of (1) sentence comprehension, (2) diagram comprehension, (3) text-diagram integration, and (4) mental animation. Subjects with law spatial ability made more errors than did subjects with high spatial ability on this task, and they made more errors on items in which more system components had to be animated to solve the problem. In contrast, the high-spatial subjects were relatively accurate on all trials. These results indicate that spatial visualization is correlated with accuracy on the motion-verification task and suggest that this correlation is primarily due to the mental animation component of the task. Reaction time and eye-fixation data revealed no differences in how the high- and low-spatial subjects decomposed the task. The data of the two groups of subjects were equally consistent with a piecemeal model of mental animation, in which components are animated one by one in order of the causal chain of events in the system.     

Computationalism

What counts as a computation and how it relates to cognitive function are important questions for scientists interested in understanding how the mind thinks. This paper argues that pragmatic aspects of explanation ultimately determine how we answer those questions by examining what is needed to make rigorous the notion of computation used in the (cognitive) sciences. It (1) outlines the connection between the Church-Turing Thesis and computational theories of physical systems, (2) differentiates merely satisfying a computational function from true computation, and finally (3) relates how we determine a true computation to the functional methodology in cognitive science. All of the discussion will be directed toward showing that the only way to connect formal notions of computation to empirical theory will be in virtue of the pragmatic aspects of explanation.     

Jury selection in two countries: a psychological perspective

A comparative survey of jury selection practices in Britain and the United States indicates that the two countries differ along a number of dimensions, including the emphasis on the jury selection process in the trial, the amount and type of information available about prospective jurors, and the frequency with which trial lawyers alter the composition of the jury. The probable impact of these differences is analysed by considering the importance of jury composition in determining a jury’s verdict, the effectiveness of lawyers in exercising their challenges, and broader effects of jury selection procedures in the two countries.     

Fuzzy-trace theory and framing effects in choice: Gist extraction,truncation, and conversion

In the first section of this paper, we analyze classic framing effects according to principles of fuzzy-trace theory. The key principle of the theory is that reasoning prefers to operate on simple gist, as opposed to exact details. Then, we introduce new data in three experiments designed to test this fuzzy-processing assumption. In the first experiment, framing effects were conserved when numerical information was omitted from standard problems, arguing against a critical role for numerical processing. In the second experiment, evidence is presented that some subjects simplified framing problems by mentally truncating linguistically redundant complements in gambles. Experimentally deleting parts of gambles mimiced such effects, and choices varied depending on the information that remained explicit. In the third experiment, truncation effects were also demonstrated for mixed-frame problems, in which one option is positive and the other is negative. The data disconfirmed a ‘halo’ hypothesis that subjects merely selected the positive option over the negative one. Instead, choices were accounted for by conversion, that is, transforming problems into uniformly positive representations to avoid the complexity of negation. In all three experiments, choices could be explained as a consequence of radically simplifying decision information.     

Grandparents and Stepgrandparents: Challenges in Counseling the Extended-Blended Family

Remarriage of parents may bring new grandparents and stepgrandparents into the lives of children, creating new family structures and needs for adjustment. The extended-blended family may benefit from specific counseling interventions.     

Virtue and Practical Deliberation

The question of how to reason well is an important normative question,one which ultimately motivates some of our interest in the more abstracttopic of the principles of practical reason. It is this normative questionthat I propose to address by arguing that given the goal of an importantkind of deliberation, we will deliberate better if we develop certainvirtues. I give an account of the virtue of stability and I argue thatstability makes reasoners (of a certain sort) reason better. Further,I suggest at the end of the paper that an account of virtues thatconduce to good reasoning might go a long way toward answering someof the traditional questions about the principles ofpractical reason.