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81.
The “gold standard” methodology for treatment efficacy research is the randomized controlled trial (RCT), which is used extensively in medical research and in other areas such as psychology. Results from a well designed and conducted RCT, which show a new treatment to be clinically and statistically superior to current standard practice, can lead to a change in clinical practice. This paper presents a tutorial on RCTs, presenting and discussing the following principles and methods: the trial protocol, choice of control treatment, eligibility criteria, random allocation, outcomes and hypotheses, sample size, subject recruitment, analysis by intention to treat, interim analysis, stopping rules, safety data monitoring/trial management, and study documentation. RCTs are a complicated and logistically involved methodology. Hence, prior to the commitment of resources to such a trial in the development of a new treatment, the safety and clinical promise of the new treatment needs to be demonstrated with preliminary studies. Such preliminary studies have been completed for the Lidcombe Program (LP) of early stuttering intervention, and an RCT of that treatment is being conducted at the time of writing. The principles and methods of RCTs are illustrated with reference to that study.
Educational objectives: The reader will understand the design principles and methods of RCTs. The reader will understand the logistics of conducting a RCT of a treatment for early stuttering. 相似文献
82.
Gaillard V Barrouillet P Jarrold C Camos V 《Journal of experimental child psychology》2011,110(3):469-479
Several models assume that working memory development depends on age-related increases in efficiency and speed of processing. However, age-related increases in the efficiency of the mechanisms that counteract forgetting and restore memory traces may also be important. This hypothesis was tested in three experiments by manipulating both the processing duration within a working memory task and the time available to restore memory traces. Third- and sixth-grade children performed a complex span task in which they maintained series of letters while adding numbers to series of digits. When we equated processing and restoration times between ages, the developmental difference in working memory span was reduced but remained significant. However, this residual difference was eliminated when the time available to reactivate memory traces was tailored to the processing speed of each age group. This indicates that children employ active mechanisms for maintenance and restoration of memory traces that develop with age. 相似文献
83.
This study examined the role of sympathetic nerves in the control of cerebral hemodynamics during air-jet stress. In adult male Sprague-Dawley rats, blood flow velocity (pulsed Doppler) was measured in both internal carotid arteries 1 week after excision of one superior cervical ganglion. Blood pressure (BP) and carotid blood flows (CBFs) were simultaneously recorded during exposure to air-jet stress. In 5 out of 13 rats, stress was applied after β(2)-adrenoceptor blockade with ICI 118551 (0.4 mg/kg, then 0.2 mg/kg/h, i.v). Stress evoked an immediate rise in BP, CBFs, and vascular conductances. Vasodilatation was much larger on the denervated side than on the intact side (mean ± SEM: 78 ± 7 versus 19 ± 4%; P < 0.02) and lasted about 10 s. Thereafter, blood flows returned to or near normal and showed parallel variations while BP remained elevated. There was, therefore, a net vasoconstriction on both sides. In ICI 118551-treated rats, the initial vasodilatation was not significantly reduced on the denervated side (64 ± 4%), but the subsequent vasoconstriction was enhanced (P < 0.05) on both sides. In conclusion, air-jet stress evokes an immediate, short-lasting vasodilatation through a mechanism unrelated to β(2)-adrenoceptor stimulation. Sympathetic nerves powerfully limit this phenomenon, and thus contribute to protect the cerebral circulation from stress-induced BP surges. 相似文献
84.
Five domestic dogs (Canis familiaris) were tested in a cooperative exchange task with an experimenter, as previously tested in non-human primates. In the first
task, the dogs exchanged to maximise payoffs when presented with food items of differing quality. All consistently exchanged
lower-value for higher-value rewards, as determined by their individual food preference, and exchanges corresponded significantly
with the spontaneous preferences of three dogs. Next, all subjects demonstrated an ability to perform two and three exchanges
in succession, to gain both qualitative and quantitatively increased rewards (group mean = 72 and 92% successful triple exchanges,
respectively). Finally, the ability to delay gratification over increasing intervals was tested; the dogs kept one food item
to exchange later for a larger item. As previously reported in non-human primates, there was considerable individual variation
in the tolerance of delays, between 10 s and 10 min for the largest rewards. For those who reached longer time lags (>40 s),
the dogs gave up the chance to exchange earlier than expected by each subject’s general waiting capacity; the dogs anticipated
delay duration and made decisions according to the relative reward values offered. Compared to primates, dogs tolerated relatively
long delays for smaller value rewards, suggesting that the socio-ecological history of domestic dogs facilitates their performance
on decision-making and delay of gratification tasks. 相似文献
85.
Aim: This article gives an overview of the setting up of the Art Therapy Practice Research Network (ATPRN) in 2000, amidst a culture resistant to research. The authors discuss their experiences in changing this culture and encouraging art therapists to become practitioner/researchers. They identify learning points that may be helpful for other professionals who want to form new practice research networks (PRNs). Context: The research and practice context contemporary to the ATPRN foundation is outlined and identified as a significant influence on its inception and development. Key events in the 14 years of the PRN's life and articles on art therapy and psychotherapy research published at the time of the ATPRN foundation are used to illuminate the historical context. ATPRN newsletters and symposium reports were consulted to identify themes and issues across 14 years of development and growth. Learning points: Several learning points are identified and listed as useful factors to address when setting up and maintaining a PRN and include: shape the culture from the start; review and revise; get practical together; encourage members' presentations; build synergy with professional body; embed the ATPRN around all aspects of research publication. Conclusions: Successful PRNs depend on making practitioners feel included from the start by acknowledging fear and anxiety about research. Providing practical projects helped practitioners to feel less isolated by being part of a meaningful and productive network. Maintaining and developing PRNs is an iterative process that demands constant reviewing and revising. 相似文献
86.
Romain Boissonnade Valérie Tartas Michèle Guidetti 《Integrative psychological & behavioral science》2014,48(3):341-364
Independently of their age, individuals produce weak logical responses when they solve the Wason selection task. Many studies describe conditional reasoning, focusing on intra-individual and general processes. The role of meaning attributed to the situation or the linguistic interpretation of the rules have nevertheless been stressed by pragmatic studies. Few scattered studies show the role of collective situations, of subjects’ prior knowledge and of objects in solving the selection task. This paper goes back to the questions raised by the selection task and attempts to place past results into a cultural-historical theoretical framework, which defines a complex and evolving cognitive system, where human beings rely on social exchanges, equip themselves with cultural instruments, create intellectual tools, and give meaning to their experiences. Taking into account such a system is necessary to shed light upon the possibilities for the development of human thinking processes in order to solve selection tasks. 相似文献
87.
Catherine S. Shilling 《The American journal of family therapy》2013,41(3):59-64
Abstract This investigation attempted to measure the relationship between parents' and their children's assertive and interpersonal behavior in order to identify the family population which can best profit from interpersonal skills training. Subjects were 60 volunteer mothers and fathers and 95 children, ages six to twelve, from a white upper socio-economic suburban population. The adult assessment measures were Fundamental Interpersonal Relations Orientation-Behavior (FIRO-B) and the Adult Self-Expression Scale. The child assessment measures were Fundamental Interpersonal Relations Orientation-Behavior Children (FIRO-BC) and Self-Expression Scale: Children. The most notable result of this study indicates that contrary to most published literature on the family, assertiveness relates to affection rather than control; that assertiveness training should be subordinated to interpersonal skills training; that the FIRO instruments provide a more effective assessment of family interaction than do assertiveness instruments. 相似文献
88.
Núria Voltas Moreso Carmen Hernández-Martínez Victoria Arija Val Josefa Canals Sans 《International Journal of Clinical and Health Psychology》2013,13(2):118-126
We assessed the presence of emotional disorders (obsessive-compulsive, anxiety and depressive) in 1,514 Spanish non-referred children (8–12 years old) to investigate the predictive ability of psychopathological and socio-demographic characteristics, and identify which of these were possible correlates for clinical obsessive-compulsive disorder (OCD) and subclinical OCD. At one year later, 562 subjects (risk group and without risk group) were re-assessed and we established the OCD diagnoses or the subclinical OCD diagnoses. We found that 20 participants presented clinical OCD and 46 participants presented subclinical OCD. Somatic and separation anxiety symptomatology were good predictors for clinical OCD, and obsessive concern was a predictor for subclinical OCD. Clinical OCD was associated with order/checking/pollution symptoms and with a lower socioeconomic status (SES). Subclinical OCD was associated with hyperactive and impulsive manifestations, obsessive concern, and superstition/mental compulsion. An early detection and the follow-up of anxiety or obsessive symptoms in children may be important for preventing the course of OCD. 相似文献
89.
Arturo Forner-Cordero Valéria D. Garcia Sérgio T. Rodrigues Jacques Duysens 《Journal of motor behavior》2013,45(5):468-478
Little is known about the ability of blind people to cross obstacles after they have explored haptically their size and position. Long-term absence of vision may affect spatial cognition in the blind while their extensive experience with the use of haptic information for guidance may lead to compensation strategies. Seven blind and 7 sighted participants (with vision available and blindfolded) walked along a flat pathway and crossed an obstacle after a haptic exploration. Blind and blindfolded subjects used different strategies to cross the obstacle. After the first 20 trials the blindfolded subjects reduced the distance between the foot and the obstacle at the toe-off instant, while the blind behaved as the subjects with full vision. Blind and blindfolded participants showed larger foot clearance than participants with vision. At foot landing the hip was more behind the foot in the blindfolded condition, while there were no differences between the blind and the vision conditions. For several parameters of the obstacle crossing task, blind people were more similar to subjects with full vision indicating that the blind subjects were able to compensate for the lack of vision. 相似文献
90.