Trace and contextual fear conditioning is enhanced in mice lacking the α4 subunit of the GABAA receptor

The GABA_AR α4 subunit is highly expressed in the dentate gyrus region of the hippocampus at predominantly extra synaptic locations where, along with the GABA_AR δ subunit, it forms GABA_A receptors that mediate a tonic inhibitory current. The present study was designed to test hippocampus-dependent and hippocampus-independent learning and memory in GABA_AR α4 subunit-deficient mice using trace and delay fear conditioning, respectively. Mice were of a mixed C57Bl/6J X 129S1/X1 genetic background from α4 heterozygous breeding pairs. The α4-knockout mice showed enhanced trace and contextual fear conditioning consistent with an enhancement of hippocampus-dependent learning and memory. These enhancements were sex-dependent, similar to previous studies in GABA_AR δ knockout mice, but differences were present in both males and females. The convergent findings between α4 and δ knockout mice suggests that tonic inhibition mediated by α4βδ GABA_A receptors negatively modulates learning and memory processes and provides further evidence that tonic inhibition makes important functional contributions to learning and behavior.     

Instagram Use and Self-Objectification: The Roles of Internalization,Comparison, Appearance Commentary,and Feminism

The current study examined potential mediators (i.e., internalization of cultural standards of beauty, engaging in upward and downward appearance comparison, and receiving positive and negative appearance-related commentary), moderators (i.e., feminist beliefs), and moderated mediation of the links between Instagram (an electronic way to share visual images) use and self-objectification and body surveillance among 492 undergraduate women from the Southeast United States. Results revealed that internalization of cultural standards of beauty and engaging in upward appearance comparison uniquely mediated Instagram usage and self-objectification and body surveillance links. Additionally, findings from the moderation analyses indicated that the direct effect of Instagram usage on body surveillance was contingent on feminist beliefs, such that this relationship was only significant among women with lower and moderate feminist beliefs. This finding suggests that higher feminist beliefs play a buffering or protective role whereas lower feminist beliefs play an intensifying role. Implications and future directions are discussed.     

Economic implications of access to daylight and views in office buildings from improved productivity

Previous research has found significant impacts of daylight and views on the cognitive function of office workers. In this study, we use scores on decision-making performance to estimate the annual economic potential of optimizing daylighting and views in U.S. offices. Cognitive scores were compared against over 100,000 previous test scores to obtain the distributional shift in cognitive performance when working in an office with optimized daylighting and views as opposed to an office with traditional blinds. These changes in performance were then compared to compensation data from the Bureau of Labor Statistics. Office workers shifted on average from the 52nd percentile to 65th percentile, equivalent to a $11,809 difference in salary per person per year. When conservatively accounting for the number of employees working within 15 ft of a window with blinds, optimizing daylight and views in U.S. offices has the potential to generate $352B ($240B–$464B), or 1.7% of the 2018 U.S. gross domestic product (GDP), in additional productivity. These findings suggest that building developers, architects and tenants should give additional attention to daylight design and façade technology as they consider new building construction, renovation and leasing options.     

Effects of Alprazolam on Complex Human Functioning1

Benzodiazepines can reduce anxiety, can have favorable effects upon sleep, and may diminish problems that interfere with patients' quality of life. On the other hand, these drugs can generate transient anterograde amnesia and may diminish aspects of task performance. Research on the impact of alprazolam and other “tranquilizing” drugs has generally focused on tasks that remain below the complex efforts of managerial or professional personnel. Alprazolam-induced reduction of anxiety under challenging conditions might aid complex task performance, yet anterograde amnesia might interfere. In the present research, managers participated in validated complex simulation tasks. In a double-blind, dual crossover design, placebo, 0.5 mg, or 1.0 mg alprazolam was administered on 2 occasions during the task day. Drug treatment diminished performance on measures that require sequential actions but improved performance on measures less subject to short term memory but more determined by long-term style of functioning. Thus, depending on task requirements, positive or negative alteration of performance might occur.     

Not all nonwords are alike: Implications for reading development and theory

Three experiments were designed to examine children's and adults' ability to pronounce consonant-vowel-consonant (CVC) nonsense words. Some of the nonwords, like tain and goach, shared their VC unit with a number of real words. Other nonwords, like goan and taich, shared their VC unit with few or no real words. Pooling across items, the very same grapheme-phoneme correspondences occurred in the two types of nonwords. First graders, good and poor third grade readers, and adults all performed better on the nonwords with the more common VC units than on the nonwords with the less common VC units. Although readers appeared to use VC units in the pronunciation of nonwords, we did not find evidence for use of initial CV units. Implications of the results for reading development, dyslexia, and models of nonword pronunciation are discussed.     

Examining the influence of group diversity on the functioning of community-based participatory research partnerships: A mixed methods study

Public health has endorsed the use of community-based participatory research (CBPR) to address health inequities involving diverse and marginalized communities. However, few studies have examined how group diversity among members of CBPR partnerships influenced how well the partnerships achieve their goals of addressing health inequities through equitable collaboration. We conducted secondary, convergent, mixed methods analysis to (1) evaluate the association between group diversity and participatory decision-making within CBPR partnerships, and (2) identify the perceived characteristics, benefits, and challenges of group diversity within CBPR partnerships. Using data from a cross-site study of federally funded CBPR partnerships, we analyzed and integrated data from surveys of 163 partnerships (n = 448 partners) and seven in-depth case study interviews (n = 55 partners). Quantitatively, none of the measured characteristics of group diversity was associated with participatory decision-making within the partnerships. Qualitatively, we found that partnerships mainly benefited from membership differences in functional characteristics (e.g., skillset) but faced challenges from membership differences in sociocultural characteristics (e.g., gender and race). The integrated findings suggest the need to further understand how emergent group characteristics and how practices that engage in group diversity contribute to collective functioning of the partnerships. Attention to this area can help promote health equity achievements of CBPR partnerships.     

“Tell Me What I Need to Know”: South Asian Women, Social Capital and Settlement

This paper reports on the findings of in-depth interviews with 50 South Asian immigrant women in Toronto regarding their settlement needs and the role of social capital in meeting these needs. The main findings discussed in this paper relate to the emergence of information as the most important settlement need and the ways in which information and orientation were obtained. Participants were found to rely on informal networks of friends and relatives as the most exhaustive and specific source of information and orientation.     

The effects of spelling consistency on phonological awareness: a comparison of English and German

Within alphabetic languages, spelling-to-sound consistency can differ dramatically. For example, English and German are very similar in their phonological and orthographic structure but not in their consistency. In English the letter a is pronounced differently in the words bank, ball, and park, whereas in German the letter a always has the same pronunciation (e.g., Ball, Park, Bank). It is often argued that reading acquisition has a reciprocal effect on phonological awareness. As reading is acquired, therefore, spoken language representation may be affected differently for English and German children. Prior to literacy acquisition, however, phonological representation in English and German children should be similar due to the similar phonological structure of the two languages. We explored this hypothesis by comparing phonological awareness at the rime and phoneme levels in prereaders and beginning readers in English and German. Similar developmental effects were indeed observed in prereaders, but differential effects had emerged within the first year of reading instruction.