Overt naming fMRI pre- and post-TMS: Two nonfluent aphasia patients, with and without improved naming post-TMS

Two chronic, nonfluent aphasia patients participated in overt naming fMRI scans, pre- and post-a series of repetitive transcranial magnetic stimulation (rTMS) treatments as part of a TMS study to improve naming. Each patient received 10, 1-Hz rTMS treatments to suppress a part of R pars triangularis. P1 was a ‘good responder’ with improved naming and phrase length; P2 was a ‘poor responder’ without improved naming.Pre-TMS (10 years poststroke), P1 had significant activation in R and L sensorimotor cortex, R IFG, and in both L and R SMA during overt naming fMRI (28% pictures named). At 3 mo. post-TMS (42% named), P1 showed continued activation in R and L sensorimotor cortex, R IFG, and in R and L SMA. At 16 mo. post-TMS (58% named), he also showed significant activation in R and L sensorimotor cortex mouth and R IFG. He now showed a significant increase in activation in the L SMA compared to pre-TMS and at 3 mo. post-TMS (p < .02; p < .05, respectively). At 16 mo. there was also greater activation in L than R SMA (p < .08). At 46 mo. post-TMS (42% named), this new LH pattern of activation continued. He improved on the Boston Naming Test from 11 pictures named pre-TMS, to scores ranging from 14 to 18 pictures, post-TMS (2–43 mo. post-TMS). His longest phrase length (Cookie Theft picture) improved from three words pre-TMS, to 5–6 words post-TMS.Pre-TMS (1.5 years poststroke), P2 had significant activation in R IFG (3% pictures named). At 3 and 6 mo. post-TMS, there was no longer significant activation in R IFG, but significant activation was present in R sensorimotor cortex. On all three fMRI scans, P2 had significant activation in both the L and R SMA. There was no new, lasting perilesional LH activation across sessions for this patient. Over time, there was little or no change in his activation. His naming remained only at 1–2 pictures during all three fMRI scans. His BNT score and longest phrase length remained at one word, post-TMS.Lesion site may play a role in each patient’s fMRI activation pattern and response to TMS treatment. P2, the poor responder, had an atypical frontal lesion in the L motor and premotor cortex that extended high, near brain vertex, with deep white matter lesion near L SMA. P2 also had frontal lesion in the posterior middle frontal gyrus, an area important for naming (Duffau et al., 2003); P1 did not. Additionally, P2 had lesion inferior and posterior to Wernicke’s area, in parts of BA 21 and 37, whereas P1 did not.The fMRI data of our patient who had good response following TMS support the notion that restoration of the LH language network is linked in part, to better recovery of naming and phrase length in nonfluent aphasia.     

What Things <Emphasis Type="Italic">Still</Emphasis> Don’t Do

This paper praises and criticizes Peter-Paul Verbeek’s What Things Do (2006). The four things that Verbeek does well are: (1) remind us of the importance of technological things; (2) bring Karl Jaspers into the conversation on technology; (3) explain how technology “co-shapes” experience by reading Bruno Latour’s actor-network theory in light of Don Ihde’s post-phenomenology; (4) develop a material aesthetics of design. The three things that Verbeek does not do well are: (1) analyze the material conditions in which things are produced; (2) criticize the social-political design and use context of things; and (3) appreciate how liberal moral-political theory contributes to our evaluation of technology.     

Fairness Perceptions of Employee Promotion Systems: A Two-Study Investigation of Antecedents and Mediators

The present research provided a test of the Ferris, Buckley, and Allen (1992) model depicting the antecedents and consequences of promotion systems in organizations. A 2-study design is utilized to investigate the role of promotion system characteristics as mediating the relationship between organizational factors, environmental factors, and job factors/employee characteristics and perceptions of organizational justice and advancement opportunity. Results provide convergence of support for the model across both studies. Implications of the results and directions for future research are discussed.     

In defense of modest probabilism

Orthodox Probabilists hold that an inquirer ought to harbor a precise degree of confidence in each hypothesis about which she is concerned. Modest Probabilism is one of a family doctrines inspired by the thought that Orthodox Probabilists are thereby demanding that an inquirer effect a precision that is often unwarranted by her evidence. The purpose of this essay is (i) to explain the particular way in which Modest Probabilism answers to this thought, and (ii) to address an alleged counterexample to Modest Probabilism meant to offer proof that Modest Probabilism is no better than its orthodox predecessor at avoiding unwarranted precision.     

Habituation, response to novelty, and dishabituation in human infants: tests of a dual-process theory of visual attention

Two experiments were conducted to test a dual-process theory of infants' performance on visual habituation-dishabituation tasks. The findings demonstrate that (a) infant habituation functions are often nonmonotonic, with fixation increasing before the eventual response waning; (b) this initial increment in responding is related to stimulus "complexity"; (c) response to novelty is enhanced by increasing the "complexity" of the novelty-test stimulus; and (d) dishabituation, followed by decay, occurs for familiarized patterns when retested after the introduction of a "complex" stimulus, but not after introduction of a "simple" stimulus. Following P. Groves and R. Thompson (1970, Psychological Review, 77, 419-450) we propose that infant visual attention to repeated presentations of a stimulus involves two processes, habituation and sensitization.     

Life cycle and loss--the spiritual vacuum of heroin addiction

This research studied the function of heroin addiction as a family-learned method of coping with death, separation, and loss across the life cycle. Heroin addicts, psychiatric outpatients, and normal students were given an extensive interview and test battery to determine the incidence of loss of family members and significant others. Because the impact of death is often overcome through religious rituals, this study also investigated the subjects' perception of their families' religious values and orientation to life's meaning and purpose. Results indicate that the incidence of death differs significantly across groups and that addicts have a distinct orientation to death, are more suicidal, and have more premature and bizarre death experiences. During childhood they have more family separations, and they tend to develop a distinct pattern of continuously separating from and returning to their families. They are also less likely to have a clearly defined purpose in life. A subset of parents from each group were also interviewed and tested, and these results support the theory of the intergenerational transmission of behavior.     

Language functioning after bilateral prefrontal leukotomy

Three groups of patients with orbital frontal lesions secondary to leukotomy were compared to psychiatric and normal control groups on a series of tasks involving language. The results indicated that chronic orbital frontal lesions, at least in the patients in this study, do not affect language as defined by the tasks used in the study. The frontal lobes, when implicated in language, appear to require dorsal-lateral or medial cortical involvement.     

Factors associated with erection in adolescent sex offenders

A majority of adult child molesters report that their deviant interest began prior to the age of 18. This illustrates the need to evaluate adolescents who have molested children. Since self-report of deviant interest is rare in adolescent offenders, psychophysiologic assessment is necessary to help to determine the extent for a deviant interest pattern. The current study was designed to determine what factors are associated with erectile responding to age-inappropriate stimuli in an adolescent sex offender population. Factors studied were (a) admit/deny, (b) history of physical abuse, (c) history of sexual abuse, (d) history of nonsex arrests, and (e) incest/nonincest. The dependent variables were two pedophile indices, a relative measure of deviant to nondeviant arousal. Results indicated that history of sexual abuse was associated with more deviant erectile responding in those adolescents who had molested young boys. The possibility of adolescents modeling their own victimization is discussed.