Nicotine and familial vulnerability to schizophrenia: a discordant twin study

Tobacco use is significantly associated with schizophrenia. However, it is not clear if smoking is associated with the illness itself, treatment, or underlying vulnerability to the disease. Smoking was studied in a sample of schizophrenic probands (n = 24), their unaffected co-twins (n = 24), and controls (n = 3,347). Unaffected co-twins had higher rates of daily smoking than controls. Probands and co-twins were more frequently unsuccessful in attempts to quit than controls. Probands reported shaky hands and depression following smoking cessation more often than controls, whereas unaffected co-twins reported difficulty concentrating, drowsiness, nervousness, and headache following smoking cessation more often than controls. Results are consistent with the hypothesis that nicotine use is influenced by familial vulnerability to schizophrenia, not just clinical schizophrenia per se.     

The resilience of object predictions: Early recognition across viewpoints and exemplars

Recognition of everyday objects can be facilitated by top-down predictions. We have proposed that these predictions are derived from rudimentary image information, or gist, extracted rapidly from the low spatial frequencies (LSFs) (Bar Journal of Cognitive Neuroscience 15: 600–609, 2003). Because of the coarse nature of LSF representations, we hypothesized here that such predictions can accommodate changes in viewpoint as well as facilitate the recognition of visually similar objects. In a repetition-priming task, we indeed observed significant facilitation of target recognition that was primed by LSF objects across moderate viewpoint changes, as well as across visually similar exemplars. These results suggest that the LSF representations are specific enough to activate accurate predictions, yet flexible enough to overcome small changes in visual appearance. Such gist representations facilitate object recognition by accommodating changes in visual appearance due to viewing conditions, and help generalize from familiar to novel exemplars.     

Training‐induced recovery of low‐level vision followed by mid‐level perceptual improvements in developmental object and face agnosia

Long‐term deprivation of normal visual inputs can cause perceptual impairments at various levels of visual function, from basic visual acuity deficits, through mid‐level deficits such as contour integration and motion coherence, to high‐level face and object agnosia. Yet it is unclear whether training during adulthood, at a post‐developmental stage of the adult visual system, can overcome such developmental impairments. Here, we visually trained LG, a developmental object and face agnosic individual. Prior to training, at the age of 20, LG's basic and mid‐level visual functions such as visual acuity, crowding effects, and contour integration were underdeveloped relative to normal adult vision, corresponding to or poorer than those of 5–6 year olds (Gilaie‐Dotan, Perry, Bonneh, Malach & Bentin, 2009). Intensive visual training, based on lateral interactions, was applied for a period of 9 months. LG's directly trained but also untrained visual functions such as visual acuity, crowding, binocular stereopsis and also mid‐level contour integration improved significantly and reached near‐age‐level performance, with long‐term (over 4 years) persistence. Moreover, mid‐level functions that were tested post‐training were found to be normal in LG. Some possible subtle improvement was observed in LG's higher‐order visual functions such as object recognition and part integration, while LG's face perception skills have not improved thus far. These results suggest that corrective training at a post‐developmental stage, even in the adult visual system, can prove effective, and its enduring effects are the basis for a revival of a developmental cascade that can lead to reduced perceptual impairments.     

Linking major depression and the neural substrates of associative processing

It has been proposed that mood correlates with the breadth of associative thinking. Here we set this hypothesis to the test in healthy and depressed individuals. Generating contextual associations engages a network of cortical regions including the parahippocampal cortex (PHC), retrosplenial complex, and medial prefrontal cortex. The link between mood, associative processing, and its underlying cortical infrastructure provides a promising avenue for elucidating the mechanisms underlying the cognitive impairments in major depressive disorder (MDD). The participants included 15 nonmedicated individuals with acute major depressive episodes and 15 healthy matched controls. In an fMRI experiment, participants viewed images of objects that were either strongly or weakly associated with a specific context (e.g., a beach chair vs. a water bottle) while rating the commonality of each object. Analyses were performed to examine the brain activation and structural differences between the groups. Consistent with our hypothesis, controls showed greater activation of the contextual associations network than did depressed participants. In addition, PHC structural volume was correlated with ruminative tendencies, and the volumes of the hippocampal subfields were significantly smaller in depressed participants. Surprisingly, depressed participants showed increased activity in the entorhinal cortex (ERC), as compared with controls. We integrated these findings within a mechanistic account linking mood and associative thinking and suggest directions for the future.     

The Spanish and Catalan Versions of the Parent Development Interview-Revised (PDI-R): Adaptation and Validation Process

The reflective function (RF) or mentalization is nowadays considered a concept with a great explanatory and therapeutic potential. In this article we present the adaptation and validation of Parent Development Interview-Revised (PDI-R) to the Spanish and Catalan languages. It was performed by a cross-sectional design with a non-clinical sample of 61 Spanish and Catalan speaking mothers of under five mentally healthy children. The same sample responded to an Adult Attachment Questionnaire and to the Child Behavior Check List. The construct hypothesis based on attachment theory and mentalization research, expected a positive correlation between the parental RF level and adult attachment. Other hypothesis did not predict significant differences in the results of the two subsamples depending on sociodemographic characteristics. The results do confirm the hypothesis considered in a concordance way with the literature. The discussion provides some qualitative analysis closer to what is expected of the PDI-R’s clinical uses as a frame to work with parents. This study represents the PDI-R’s introduction in the Spanish and Catalan speaking population over the world. We think it opens the door to further research assessing the parental RF with Spanish speaking parents’ samples as well as to guide the clinical work with them.     

Emotions,Risk Perceptions,and Precautionary Behavior Under the Threat of Terror Attacks: A Field Study Among Israeli College Students

The current study uses the unique data from a natural experiment conducted in a college located in southern Israel that was exposed to rocket attacks in 2008. The study examines the relationships between the negative emotions, the perceptions of risk to oneself, the precautionary actions, and the intentions of 290 students who were exposed to terror attacks while on campus. In addition, we compared the emotions, the risk perceptions, and the precautionary behavior between the two groups: those who lived within the range of the rockets and were also exposed to rocket attacks at home and those who lived outside the range of the rockets. The results show that the risk perceptions were affected mainly by the emotion of fear while the students were on campus. In particular, fearful people became more pessimistic about their general and personal risks from terror but not about routine risks. The results also reveal that those who lived outside the rocket area (and had less or no experience with terror attacks) were more likely to take precautionary actions during their stay in the campus and were more pessimistic about continuing their studies in college in the coming year than those living in the area, who had more experience with terror attacks. Copyright © 2011 John Wiley & Sons, Ltd.     

The Historical Character of Human Nature in Freud's Theories

In Freud’ theories of human development, human nature is described and analyzed as essentially historical. At the core of human history is the restructuring of the sexual instinct and the death instinct (or its unique form as destructive impulses). The conscious, asked-for shaping of these two instincts, under the rule of the “reality principle”, forms the basis of human society at all stages. This conscious restructuring has also unintended, unasked-for results, which are part of the historically developing human nature. The historical choice has been the building of human society as a social complex based on the de-eroticization of both the individual and society. Freud suggested that the historical process of changing human nature and maintaining the achieved new structure has mainly been an enterprise of enlightened political elite, which has imposed (in all societies) the various elements of the new nature upon the ordinary people. Human history is essentially a deed of the political sphere. In viewing human nature as consisting of both asked-for and unasked-for results of human conscious purposeful activity Freud belongs to the same historical school as Marx.     

EDITOR'S NOTE

The article deals with the ways in which Mizrahim—Jewish immigrants who came to the State of Israel after 1948—influenced the local Jewish sacred geography. Besides taking part in rituals in the older and more established holy places such as King David’s Tomb on Mount Zion, Mizrahim tended to adopt and develop holy places where only hints of ancient Jewish sanctity were to be found. These places were used before 1948 mainly by the local Muslim population and were adopted now by Jews. This reality prevailed mainly in the social and geographical periphery of Israel, in regions and places where immigrants were usually settled by the Israeli establishment during the 1950s and 1960s. Mizrahim, in need of accessible and informal holy sites near their new settlements, brought now to the development of such places as the Tomb of Raban Gamliel in Yavne, the Tomb of Judah in Yahud, and the Tomb of Benjamin near Kfar‐Saba. The emergence of this sacred space, in a state that had just come into being and into which there had been mass immigration of Mizrahim, displacing or replacing the indigenous population of Arabs, is at the heart of the paper.