Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory

N-methyl-D-aspartate (NMDA) receptors play an important role in excitatory neurotransmission and mediate synaptic plasticity associated with learning and memory. NMDA receptors are composed of two NR1 and two NR2 subunits and the identity of the NR2 subunit confers unique electrophysiologic and pharmacologic properties to the receptor. The precise role of NR2C-containing receptors in vivo is poorly understood. We have performed a battery of behavioral tests on NR2C knockout/nβ-galactosidase knock-in mice and found no difference in spontaneous activity, basal anxiety, forced-swim immobility, novel object recognition, pain sensitivity and reference memory in comparison to wildtype counterparts. However, NR2C knockout mice were found to exhibit deficits in fear acquisition and working memory compared to wildtype mice. Deficit in fear acquisition correlated with lack of fear conditioning-induced plasticity at the thalamo-amygdala synapse. These findings suggest a unique role of NR2C-containing receptors in associative and executive learning representing a novel therapeutic target for deficits in cognition.     

The Phenomenological Film Collective: Introducing a cinematic‐phenomenological research method for social advocacy filmmaking

This paper introduces the vision for the Phenomenological Film Collective ( pfcollective.com ), a research and filmmaking group which utilizes phenomenological research in the service of social advocacy filmmaking. I outline the theoretical and methodological underpinnings of developing a “cinematic‐phenomenological research method” for PFCollective in order to illuminate lived experiences of sociocultural oppression for public viewership via cinematography. The roots of cinematic phenomenology are situated within the theoretical framework of liberation psychology, which calls on psychologists to pursue research that can facilitate consciousness‐raising and social justice across society. The paper provides a methodological overview of existential‐hermeneutic phenomenological research and discusses how its research findings can be disseminated to the widespread public in artistic formats. I demonstrate how filmmaking is an appropriate aesthetic language through which to disseminate phenomenological research about lived experiences of oppression, grounding this proposition in phenomenological philosophy and liberation psychology. I outline the procedural steps for conducting cinematic‐phenomenological research to produce phenomenological films about oppressive sociocultural phenomena. The paper concludes with suggestions for academic disciplines to become more interdisciplinary in our collective pursuit for social advocacy and change.     

Theoretical and computational analysis of skill learning, repetition priming, and procedural memory

This article analyzes the relationship between skill learning and repetition priming, 2 implicit memory phenomena. A number of reports have suggested that skill learning and repetition priming can be dissociated from each other and are therefore based on different mechanisms. The authors present a theoretical analysis showing that previous results cannot be regarded as evidence of a processing dissociation between skill learning and repetition priming. The authors also present a single-mechanism computational model that simulates a specific experimental task and exhibits both skill learning and repetition priming, as well as a number of apparent dissociations between these measures. These theoretical and computational analyses provide complementary evidence that skill learning and repetition priming are aspects of a single underlying mechanism that has the characteristics of procedural memory.     

Distributional Models of Category Concepts Based on Names of Category Members

Cognitive scientists have long used distributional semantic representations of categories. The predominant approach uses distributional representations of category-denoting nouns, such as “city” for the category city. We propose a novel scheme that represents categories as prototypes over representations of names of its members, such as “Barcelona,” “Mumbai,” and “Wuhan” for the category city. This name-based representation empirically outperforms the noun-based representation on two experiments (modeling human judgments of category relatedness and predicting category membership) with particular improvements for ambiguous nouns. We discuss the model complexity of both classes of models and argue that the name-based model has superior explanatory potential with regard to concept acquisition.     

Texture development during cross rolling of a dual-phase Fe–Cr–Ni alloy: experiments and simulations

Texture development during multi-step cross rolling of a dual-phase Fe–Cr–Ni alloy has been investigated. X-ray diffraction was used to investigate changes in crystallographic texture of both the constituent phases (austenite and ferrite) through changes in orientation distribution function. After deformation, rotated brass (rotated along φ₁, i.e. the sample normal direction ND), along with a weak cube texture was observed in austenite, while a strong rotated cube texture was obtained in ferrite. Texture was also simulated for various strains using a co-deformation model by self-consistent visco-plastic (VPSC) formulation. Simulations showed strong rotated brass texture in austenite and a strongly rotated cube, α-fibre (sample rolling direction RD //<1 1 0>) and γ-fibre (ND //<1 1 1>) in ferrite after highest strain (ε_t = 1.6). VPSC models could not effectively capture the change in crystallographic texture during cross rolling. In ferrite, simulations showed an overestimation of γ-fibre component and an underestimation of rotated cube component. Simulated texture of austenite, on the other hand, showed an overestimation of rotated brass with an absence of cube component. The results are rationalised based on the possible role of shear banding and activation of non-octahedral slip system during cross rolling, both of which are not incorporated in conventional VPSC models.     

Attribute Partitioning in Multiple Attribute Decision Making Problems for a Decision with a Purpose – a Fuzzy Approach

This work introduces a methodology to find solutions corresponding to different purposes in a multiple attribute decision‐making problem under fuzzy environment. The discernment of purpose‐based solutions becomes important when the problem is defined vaguely and solution is targeted to heterogeneous population. Depending on the purpose, for which the solution is sought, the attributes are identified and weighted in an appropriate proportion. The level of similarity between a pair of attributes plays an important role to determine the aggregated value of attributes specific to a purpose. Our work determines the similarity levels between a pair of attributes by calculating their maximum attainability in presence of each other. The achievement of an attribute in presence of another is represented as a fuzzy set in the unit interval. The crisp equivalents of the fuzzy sets in the unit interval are used to define their simultaneous satisfaction denoted as 1‐step relation. The 1‐step relation is extended to (m‐1)‐step relation to calculate the degree of attainability of the same pair of attributes in the presence of m (all) attributes. The different levels of (m‐1)‐step relations generate several partitions of the attributes corresponding to multiple purposes in the multiple attribute decision‐making problems. The degree of fulfilment of the purposes in the alternatives are numerically derived by first taking weighted average of attributes within the equivalence classes of a partition and then aggregating the values corresponding to equivalence classes through ordered weighted averaging. The methodology is illustrated with a numerical example. Copyright © 2016 John Wiley & Sons, Ltd.     

Tasks determine what is learned in visual statistical learning

Visual statistical learning (VSL), the unsupervised learning of statistical contingencies across time and space, may play a key role in efficient and predictive encoding of the perceptual world. How VSL capabilities vary as a function of ongoing task demands is still poorly understood. VSL is modulated by selective attention and faces interference from some secondary tasks, but there is little evidence that the types of contingencies learned in VSL are sensitive to task demands. We found a powerful effect of task on what is learned in VSL. Participants first completed a visual familiarization task requiring judgments of face gender (female/male) or scene location (interior/exterior). Statistical regularities were embedded between stimulus pairs. During a surprise recognition phase, participants showed less recognition for pairs that had required a change in response key (e.g., female followed by male) or task (e.g., female followed by indoor) during familiarization. When familiarization required detection of “flicker” or “jiggle” events unrelated to image content, there was weaker, but uniform, VSL across pair types. These results suggest that simple task manipulations play a strong role in modulating the distribution of learning over different pair combinations. Such variations may arise from task and response conflict or because the manner in which images are processed is altered.