Genetic Cancer Risk Assessment and Counseling: Recommendations of the National Society of Genetic Counselors

These cancer genetic counseling recommendations describe the medical, psychosocial, and ethical ramifications of identifying at-risk individuals through cancer risk assessment with or without genetic testing. They were developed by members of the Practice Issues Subcommittee of the National Society of Genetic Counselors Cancer Genetic Counseling Special Interest Group. The information contained in this document is derived from extensive review of the current literature on cancer genetic risk assessment and counseling as well as the personal expertise of genetic counselors specializing in cancer genetics. The recommendations are intended to provide information about the process of genetic counseling and risk assessment for hereditary cancer disorders rather than specific information about individual syndromes. Key components include the intake (medical and family histories), psychosocial assessment (assessment of risk perception), cancer risk assessment (determination and communication of risk), molecular testing for hereditary cancer syndromes (regulations, informed consent, and counseling process), and follow-up considerations. These recommendations should not be construed as dictating an exclusive course of management, nor does use of such recommendations guarantee a particular outcome. These recommendations do not displace a health care provider's professional judgment based on the clinical circumstances of a client.     

Government initiatives in autism clinical trials

Randomized clinical trials remain the most valid method of testing the efficacy and safety of treatments. While efforts to elucidate the genetic and neurodevelopmental bases of autism are underway, clinicians and families are in need of scientifically valid information on how to best treat patients with autism. The effectiveness of many interventions currently used in communities has not been adequately tested. Given the high public health relevance of autism treatment research and the low interest of the pharmaceutical industry in autism, the role of the National Institutes of Health in supporting this research is paramount. Among recently launched initiatives in autism clinical trials, there are the Research Units on Pediatric Psychopharmacology Autism Network and the network of centers for Studies to Advance Autism Research and Treatment. These and other government activities in the area of autism clinical trials are here briefly reviewed.     

Awareness in memory: being explicit about the role of sleep

Sleep is crucial to the 'off-line' consolidation of procedural memory. A recent study by Robertson et al. shows that this might hold true only if the task is trained explicitly, that is, with the subject being aware of the task structure. These new data add to emerging evidence that sleep-related memory consolidation involves an interaction between different memory systems.     

Accuracy of blood glucose estimation by children with diabetes: an investigation of repeated practice with growth curve modeling

This study used growth curve modeling to explore whether practicing the task of estimating blood glucose levels would increase accuracy in children with type 1 diabetes. It was predicted that accuracy would improve with practice and that younger, anxious, poorly adjusted children would improve most. 43 attendees at a diabetes summer camp participated. Their mean age was 13.4 yr. (SD = 1.6). All were Euro-American, and 22 were girls. Change in accuracy was best represented by a quadratic function, and this model fit the data well. Overall, participants' accuracy improved initially and then deteriorated. Results indicate that older children were more likely to improve and then deteriorate. Younger children were more likely to improve and sustain those improvements. Results indicate that practicing the task of estimating is not an effective way to increase accuracy and may be contra-indicated. These results can help guide research and clinical use of glucose estimation in children.     

Interactions between Knowledge,Action and Commitment within Agent Dynamic Logic

This paper considers a new class of agent dynamic logics which provide a formal means of specifying and reasoning about the agents activities and informational, motivational and practical aspects of the behaviour of the agents. We present a Hilbert-style deductive system for a basic agent dynamic logic and consider a number of extensions of this logic with axiom schemata formalising interactions between knowledge and commitment (expressing an agent s awareness of her commitments), and interactions between knowledge and actions (expressing no learning and persistence of knowledge after actions). The deductive systems are proved sound and complete with respect to a Kripke-style semantics. Each of the considered logics is shown to have the small model property and therefore decidable.Presented by Ewa Orlowska     

Using broad measures of maladjustment to assess psychological states of outpatients with schizophrenia

Two broad indexes of maladjustment derived from two projective tests and administered at two separate points to the same 50 outpatients with schizophrenia showed substantial convergent validity at both testings (r=.52, p<.001; r=.58, p<.001). Conversely, test-retest reliabilities for both indexes were nonsignificant. These findings suggest that broad measures of maladjustment may be more suitable for reflecting current states of adjustment for subjects known to be diagnosed with certain symptoms, the manifestations of which fluctuate over time.     

Der Familienname von Edmund Husserl

Ohne ZusammenfassungUniversität Würzburg